A5009344802- Tuberculosis Research and Epidemiology
- Mycobacterium research and diagnosis
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Infectious Diseases and Tuberculosis
- HIV Research and Treatment
- Mosquito-borne diseases and control
- Virology and Viral Diseases
- Malaria Research and Control
- vaccines and immunoinformatics approaches
- Hepatitis Viruses Studies and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Pneumonia and Respiratory Infections
- Celiac Disease Research and Management
- Diagnosis and treatment of tuberculosis
- Systemic Sclerosis and Related Diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Respiratory viral infections research
- Blood groups and transfusion
- Influenza Virus Research Studies
- Syphilis Diagnosis and Treatment
- Animal Virus Infections Studies
- HIV/AIDS Impact and Responses
Hassan II Academy of Science and Technology
2015-2024
Institut National d'Hygiène du Maroc
2008-2020
Mohammed V University
2017
Université Mohammed VI des Sciences de la Santé
2015
Institut National d’Hygiène Publique
2013
National Institute Of Hygiene And Epidemiology
2011-2013
Ministère de la Santé
2011-2012
Johns Hopkins Medicine
2011
Johns Hopkins University
2011
MRC Laboratory of Molecular Biology
2011
Patients with tuberculosis require retreatment if they fail or default from initial treatment relapse following success. Outcomes among patients receiving a standard World Health Organization Category II regimen are suboptimal, resulting in increased risk of morbidity, drug resistance, and transmission.. In this study, we evaluated the factors for failure, default, early leading to need Morocco. We also assessed outcomes susceptibility testing use urban centers Morocco, where incidence is...
Abstract One hundred samples of dried fruits (20 raisins, 20 walnuts, peanuts, figs and pistachios) rice purchased from retail shops in the Rabat Salé area Morocco were analysed for ochratoxin A (OTA) by immunoaffinity clean-up (IAC) liquid chromatography (LC) with fluorescence detection. The limit quantification (LOQ) (S/N = 10:1) OTA was 0.02 ng g−1 rice, 0.03 pistachio, peanut walnut, raisins figs. incidences occurrence 30, 35, 25, 65 90%, respectively. Analytical results showed that...
<b>Background:</b> The association between herpes simplex virus type 2 (HSV-2) and human immunodeficiency (HIV) the development of HSV vaccines have increased interest in study epidemiology. <b>Objectives:</b> To estimate age sex specific seroprevalence HSV-1 HSV-2 infections selected populations Brazil, Estonia, India, Morocco, Sri Lanka. <b>Methods:</b> Serum samples were collected from various including children, antenatal clinic attenders, blood donors, hospital inpatients, HIV sentinel...
Setting Public tuberculosis (TB) clinics in urban Morocco. Objective Explore risk factors for TB treatment default and develop a prediction tool. Assess consequences of default, specifically transmission or development drug resistance. Design Case-control study comparing patients who defaulted from completed it using quantitative methods open-ended questions. Results were interpreted light health professionals' perspectives parallel study. A predictive model simple tool to identify at high...
Acute gastroenteritis is a serious cause of child mortality and morbidity in resource-limited countries. A viral etiology most common, rotavirus norovirus are reported to be the leading causative agents. There still few epidemiological data on simultaneous occurrence these viruses Morocco. The aim this study was provide useful associated with among children aged less than 5 years.From January December 2011, 335 samples were tested for using enzyme-linked immunosorbent assay,...
Abstract Mycobacterium tuberculosis , the causal agent of pulmonary (TB), remains a major health problem throughout world causing high mortality in humans. Previous studies showed that several genes may play crucial roles susceptibility to TB. The PTPN22 gene encodes lymphoid tyrosine phosphatase has an important regulatory effect on T‐ and B‐cell activation immune response. purpose this study was investigate role two functional missense single nucleotide polymorphisms (SNPs) region (R620W...
Background There is limited information about the epidemiology of influenza in Africa. We describe and seasonality Morocco from 1996 to 2009 with particular emphasis on 2007–2008 2008–2009 seasons. Successes challenges enhanced surveillance system introduced 2007 are also discussed. Methods Virologic sentinel for virus was initiated using a network private practitioners that collected oro-pharyngeal naso-pharyngeal swabs outpatients presenting influenza-like-illness (ILI). The expanded over...
Introduction: Toll-like receptors (TLRs) 2, 4, and the vitamin D receptor (VDR) are central components of innate adaptive immunity against Mycobacterium tuberculosis (Mtb). TLR2, TLR4, VDR polymorphisms were previously associated with (TB) here investigated as candidates for pulmonary TB (PTB) susceptibility in a Moroccan population group. Methodology: Genomic DNA from 343 PTB patients 203 healthy controls analyzed 12 single nucleotide (SNPs) located genes using polymerase chain...
We present the incidence and immunologic characteristics of acute lymphoblastic leukemia (ALL) subsets in Moroccan children. studied 279 unselected patients below age 18 years with newly diagnosed ALL. Cases were classified according to immunophenotype: 216 (77.42%) precursor B-cell phenotype (pB-cell), mature 4 (1.43%), T-cell 59 (21.15%) cases. The distribution showed a peak between 3 5 among pB-cell ALLs subtype. There was significantly higher frequency males T-ALL subset more females...
Vaccination uptake of pregnant women in Morocco during the A (H1N1) pdm09 pandemic was lower than expected. qualitative study using open-ended questions developed to explore main determinants acceptance and non-acceptance monovalent vaccine among identify information sources that influenced their decision-making process. The sample included 123 vaccinated unvaccinated who were second or third trimester between December 2009 March 2010. They took part 14 focus group discussions eight in-depth...
Standard 24-locus Mycobacterial Interspersed Repetitive Unit Variable Number Tandem Repeat (MIRU-VNTR) typing allows to get an improved resolution power for tracing TB transmission and predicting different strain (sub) lineages in a community.During 2010-2012, total of 168 Mycobacterium tuberculosis Complex (MTBC) isolates were collected by cluster sampling from 10 Moroccan cities, centralized the National Reference Laboratory Tuberculosis over study period. All genotyped using...
Aim To evaluate knowledge and perception of hepatitis B, including prevention, among Moroccan health care workers (HCWs) to estimate seroprevalence B vaccine coverage (VC). Methods Four hundred twenty HCWs were randomly selected stratified by site: 120 in Rabat, 140 Taza 160 Témara–Skhirat. The study included an anonymous questionnaire about its prevention a serological survey. Oral statements registers used analyse the VC HCWs. Serological testing analysed according occupational exposure....
The aim of this study was to provide genetic and anthropological information on the Chaouya (CH), an Arabic-speaking population living in West Morocco, Atlantic coast (Settat). In 98 unrelated healthy CH volunteers, we first investigated human leukocyte antigen (HLA) class I II allele polymorphisms using a sequence-based typing method examined haplotypes relatedness group other African Mediterranean populations. showed close with Tunisian North Africans, together strong influence various...
Abstract Rotavirus vaccine was introduced in Morocco during 2010. In anticipation of introducing rotavirus vaccines, the Ministry Health established a surveillance network June 2006 at four hospitals to obtain baseline data on disease burden and prevalent strains. From May 2009, stool samples were collected from children under 5 years age admitted for diarrhea sentinel serving different regions Morocco. Rotaviruses detected stools using enzyme immunoassay, then genotyped by...
Introduction: Despite the medical progress in treatment. Tuberculosis (TB) continues to be a serious global health problem. A genome-wide linkage study identified major susceptibility locus on chromosomal region 8q12-q13 Moroccan TB patients. The CYP7A1 gene is located this and codes for cholesterol 7a-hydroxylase, an enzyme involved catabolism.
Since the confirmation of measles cases represents an important indicator regarding performance measles-elimination program, aim this study was to evaluate effectiveness routine procedures followed in Morocco for laboratory cases. Suspected reported between January 2010 and December 2012 were assessed timeliness sample collection, occurrence clinical symptoms, results diagnoses. For 88% 2,708 suspected cases, a specimen collected within 7d rash onset, which 50% IgM-positive 2.6% equivocal....
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with high female predominance. To date, studies about SLE in Morocco are few. This retrospective study describes the clinical and immunological features series of 50 Moroccan patients University Hospital Center Rabat, Morocco, between December 2011 2013. All were screened for antinuclear antibodies (ANA) anti-DNA by indirect immunofluorescence, followed identification anti-extractable nuclear antigen ELISA. The to male ratio...
In anticipation of vaccine introduction, we assessed the epidemiology, burden, and genotype infecting strains rotavirus disease among Moroccan children hospitalized for acute gastroenteritis.From June 2006 through May 2007, 345 <5 years age who had gastroenteritis were admitted to 4 sentinel hospitals in different regions Morocco enrolled this surveillance study, stool specimens tested presence with use enzyme immunoassay. RNA from positive samples was genotyped by reverse-transcriptase...
The most common monogenic form of obesity is caused by mutations in the gene encoding melanocortin-4 receptor (MC4R). We have screened MC4R coding sequence 291 patients a Dutch outpatient pediatric clinic. analyzed minimal promoter region random subgroup 217 children. Our aims were (i) to determine frequency cohort clinically obese children and (ii) search for gene. Eleven variants detected. Five had that been shown affect function other research groups (p.Y35X, p.I251fs, p.G231S). These did...