A5109753228- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- BRCA gene mutations in cancer
- Obesity, Physical Activity, Diet
- Breast Cancer Treatment Studies
- Cancer Genomics and Diagnostics
- Diet and metabolism studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Genetic factors in colorectal cancer
- Dietary Effects on Health
- Genetics and Neurodevelopmental Disorders
- Celiac Disease Research and Management
- Viral gastroenteritis research and epidemiology
- Maternal and Perinatal Health Interventions
- Gut microbiota and health
- HER2/EGFR in Cancer Research
- Coastal and Marine Management
- Genomic variations and chromosomal abnormalities
- Neonatal Respiratory Health Research
- Escherichia coli research studies
- DNA Repair Mechanisms
- Ovarian cancer diagnosis and treatment
- Microplastics and Plastic Pollution
- Blood groups and transfusion
- Listeria monocytogenes in Food Safety
Abdelmalek Essaâdi University
2016-2025
Mohammed V University
2023
Centre Hospitalier Ibn Sina
2017
Hôpital d'Enfants
2017
Centre Hospitalier Universitaire de Rabat-Salé
2015-2016
Laboratoire National de Référence
2015
National Centre for Nuclear Energy, Science and Technology
2011
Université Ibn-Tofail
2011
École Nationale de Commerce et de Gestion de Tanger
2003
Centre de Recherche Saint-Antoine
1992
Obesity is a chronic inflammatory disease defined by an excessive accumulation of body fat. The human gut microbiota (GM) intricate ecosystem microorganisms living symbiotically within the gastrointestinal tract and has emerged as key player in health metabolic diseases. Recently, several studies have increasingly revolved around understanding specific compositions strains GM their potential impact on obesity. This review provides summary most recent findings regarding obesity newly...
A1 Predictive and prognostic biomarker panel for targeted application of radioembolisation improving individual outcomes in hepatocellular carcinoma Jella-Andrea Abraham, Olga Golubnitschaja A2 Integrated market access approach amplifying value “Rx-CDx” Ildar Akhmetov A3 Disaster response: an opportunity to improve global healthcare Russell J. Andrews, Leonidas Quintana A4 USA PPPM: proscriptive, profligate, profiteering medicine-good 1 % wealthy, not 99 unhealthy Andrews A5 The role IDO a...
The six major non-O157 serogroups of Shiga toxin-producing Escherichia coli (STEC) are responsible for serious foodborne outbreaks worldwide. This research aimed to detect the STEC in ground beef, artisanal dairy products, lettuce, spinach, turkey, and chicken sold northern Morocco. Real-time polymerase chain reaction was utilized identify presence stx1, stx2, eae, wzx O26, O45, O103, wbdl O111, O121, ihp1 O145 genes. Out 310 samples analyzed, toxin (stx) detected 55 enrichments (17.74%),...
Objectives . The study aimed to assess the relationship between body fat and each of mass index (BMI) waist circumference (WC), test effectiveness (FM), percent (PBF), BMI, WC in predicting high levels fasting blood glucose (FBG). Methods A total 167 adolescents aged 11–17 years were recruited from Rabat region. BMI determined using standard equipments. FM PBF derived isotope dilution technique. FBG was by hexokinase method. Results Regardless weight status, showed a strong positive...
Literature data reported a higher frequency of breast cancer in young women (BCYW) developing countries. BCYW is associated with delayed diagnosis, aggressive biology and poor prognosis. However, our knowledge biological profile, treatment received outcome patients still limited Morocco. We propose to analyze clinicopathologic, therapeutic prognostic features among series native and/or inhabitant North carried out retro-prospective study 331 infiltrating cases registered between January 2010...
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease with high female predominance. To date, studies about SLE in Morocco are few. This retrospective study describes the clinical and immunological features series of 50 Moroccan patients University Hospital Center Rabat, Morocco, between December 2011 2013. All were screened for antinuclear antibodies (ANA) anti-DNA by indirect immunofluorescence, followed identification anti-extractable nuclear antigen ELISA. The to male ratio...
Abstract Background Hereditary breast and ovarian cancer (HBOC) is an autosomal dominant inherited susceptibility disorder. Both BRCA1 BRCA2 genes are considered as high penetrance of this syndrome. The identification BRCA1/2 genetic alterations before development, grant patients the chance to benefit from various medical prevention approaches. Therefore, appearance recent advanced technologies in molecular analysis such next generation sequencing has simplified full analysis. Many attempts...
Abstract Background To date, the contribution of BRCA1/2 mutations in Moroccan early onset breast cancer patients remains unknown. Here we assess these genetic alterations for first time a cohort from North Morocco. Methods Thirty-three diagnosed with at age ≤40 years were recruited irrespective and/or ovarian family history. Coding regions and intron-exon boundaries BRCA1 BRCA2 genes sequenced peripheral blood DNA using Ion Proton (Thermo Fisher Scientific) next generation sequencing...
Triple Negative Breast Cancer (TNBC) is defined by a lack of estrogen and progesterone receptor gene expression the absence overexpression on HER2. It associated to poor prognosis. We propose analyze clinicopathologic prognostic characteristics this breast cancer subtype in Mediterranean population originated or resident North Morocco. conducted retrospective study 279 patients diagnosed with between January 2010 2015. Clinicopathologic features have been analyzed. Disease-Free Survival...
Nasopharyngeal carcinoma is a multifactorial disease mainly affecting the Asian and North African populations including Morocco. This study aimed to determine epidemiological profile of nasopharyngeal in Northern Morocco as well its clinicopathological, therapeutic, prognostic characteristics.129 patients with followed at regional center oncology Tangier period between April 2017 July 2019, diagnosed elsewhere from March 2000 February were included this study. Statistical analysis data was...
β-Thalassemia (thal) is the most common recessive inherited disorder in Mediterranean populations. It estimated that frequency of this disease Moroccan population between 1.5 and 3.0%. Severe forms homozygous thalassemia cases require expensive technically demanding curative (bone marrow transplantation) or palliative (chronic transfusion/chelation) therapies. The −158 (C→T) polymorphism Gγ-globin gene (XmnI polymorphism) known to ameliorate severity because it strong association with an...
Unlike the other hemoglobinopathies, few researches have been published concerning α-thalassemia in Morocco. The epidemiological features and mutation spectrum of this disease are still unknown. This regional newborn screening is first to study north During period from January 2015 December 2016, 1658 newborns umbilical blood samples were investigated. Suspected screened for α-globin defects using Gap-PCR Multiplex Ligation-dependent Probe Amplification technique. prevalence α-thalassemia,...
Consanguinity is a social behavior characterized by the arrangement of marriages between relatives. It coincides generally with geographic distribution recessive genetic diseases as it increases likelihood homozygosis and, consequently, incidence their pathologies in population. In this pilot study, we assess effect inbreeding on burden hemoglobinopathies Northern Morocco. From January 2016 to December 2018, 197 children born studied region three ancestral generations and diagnosed were...
La rupture prématurée des membranes (RPM) à terme survient dans 5 10% grossesses. Elle rend compte d'une part importante de morbidité et mortalité néonatales. Le but cette étude est déterminer les facteurs pronostiques maternels obstétricaux ainsi que le devenir nouveau-nés issus grossesse compliquée ayant été hospitalisés au service ou gérés la consultation externe. Etude rétrospective, analysant toutes observations grossesses compliquées RPM, enregistrées néonatologie l'hôpital d'enfants...
On a field trip to the Dogon country (le Pays Dogon) in central Mali, we detected high frequency of Hb A2 abnormality, reaching higher numbers among blacksmiths (up 12.4%) living same villages. In this report, by direct nucleotide sequencing and employing polymerase chain reaction‐restriction fragment length polymorphism approach, show that variant observed population is indeed A2′, also called B2, all cases abnormal δ‐globin gene linked unique haplotype. The haplotype was found A2′ Herero...
The occurrence of secondary breast cancers in women previously exposed to chest irradiation for Hodgkin lymphoma (HL) is considered as a major issue the quality life these long-term survivors well challenge clinical management.This study reports case woman treated HL at age 24 years, who developed cancer after an interval 20 years.This highlights once again importance awareness among about their increased risk and re-launches debate efficacy adoption screening guidelines.
Abstract Background Triple‐negative breast cancer (TNBC) is strongly associated with BRCA1 and BRCA2 germline pathogenic variants. Revised NCCN guidelines recommend that TNBC patients ≤60 years of age should be referred for genetic counseling consideration BRCA1/2 testing. The aim the present study to characterize variants in a series from north Morocco. Methods We analyzed genes by next generation sequencing cohort 32 unselected family history diagnosis. Results Among TNBC, 7 carried or...