A5058828504- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- Mosquito-borne diseases and control
- Dermatology and Skin Diseases
- Antimicrobial Peptides and Activities
- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
- Immune cells in cancer
- 3D Printing in Biomedical Research
- Pediatric health and respiratory diseases
- Autophagy in Disease and Therapy
- Cutaneous lymphoproliferative disorders research
- Neuroinflammation and Neurodegeneration Mechanisms
- Viral Infections and Outbreaks Research
- vaccines and immunoinformatics approaches
- Viral Infections and Vectors
- Psoriasis: Treatment and Pathogenesis
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Transgenic Plants and Applications
- Urticaria and Related Conditions
- HIV Research and Treatment
- Nerve injury and regeneration
Immunologie, Immunopathologie et Chimie Thérapeutique
2014-2024
Institut de Biologie Moléculaire et Cellulaire
2014-2024
Institut Polytechnique de Bordeaux
2022-2024
Centre National de la Recherche Scientifique
2015-2024
Université de Strasbourg
2014-2024
Université Laval
2020
Medical University of Vienna
2019
University Medical Center of the Johannes Gutenberg University Mainz
2019
Johannes Gutenberg University Mainz
2019
Medical University of Graz
2019
Abstract Dendritic cells (DC) are APCs essential for the development of primary immune responses. In pluristratified epithelia, Langerhans (LC) a critical subset DC which take up Ags and migrate toward lymph nodes upon inflammatory stimuli. TLR allow detection pathogen-associated molecular patterns (PAMP) by different subsets. The repertoire expressed human LC is uncharacterized their ability to directly respond PAMP has not been systematically investigated. this study, we show first time...
Gram-positive bacteria entering the dentinal tissue during carious process are suspected to influence immune response in human dental pulp. Odontoblasts situated at pulp/dentin interface first cells encountered by these and therefore could play a crucial role this response. In present study, we found that vitro-differentiated odontoblasts constitutively expressed pattern recognition receptor TLR1-6 9 genes but not TLR7, 8, 10. Furthermore, lipoteichoic acid (LTA), wall component of bacteria,...
Abstract Skin dendritic cells ( DC s) control the immunogenicity of cutaneously administered vaccines. Antigens targeted to s via C ‐type lectin Langerin/ CD 207 are cross‐presented 8 + T in vivo . We investigated relative roles Langerhans LC and Langerin dermal dDC different vaccination settings. Poly(I:C) anti‐ 40 agonist antibody promoted cytotoxic responses upon intradermal immunization with ovalbumin OVA )‐coupled anti‐Langerin antibodies (Langerin/OVA). This correlated CD70...
Macrophages play integral roles in maintaining homeostasis and function their tissues of residence. In the skin, prenatally seeded highly specialized macrophages physically interact with sensory nerves contribute to regeneration after injury. However, mechanisms underlying development maintenance this potentially lifelong commitment nociceptors remain largely elusive. Here, we found that infiltrating myeloid progenitor cells approached sprouting axons gradually adopted a nerve-associated...
Dendritic cells (DC) play a central role in immunity/tolerance decision, depending on their activation/maturation state. TNF‐α is largely produced the skin under inflammatory conditions. However, it still remains to be defined how modulates activation status of human LC, most specialized DC controlling immunity. Here, we reported that fresh immature highly purified from healthy and exposed for two days serum‐free conditions, expressed up‐regulated level co‐stimulatory molecules (CD40, CD54,...
Summary Langerin/CD207 is expressed by a subset of dendritic cells (DC), the epithelial Langerhans cells. However, langerin also detected among lymphoid tissue DC. Here, we describe striking differences in langerin‐expressing between inbred mouse strains. While + are observed comparable numbers and with phenotypes epidermis, two distinct DC subsets bear peripheral, skin‐draining lymph nodes BALB/c mice (CD11c high CD8α CD11c low ), whereas only latter present C57BL/6 mice. The mesenteric...
Langerhans cells, a subset of skin dendritic cells in the epidermis, survey peripheral tissue for invading pathogens. In recent functional studies it was proven that can present exogenous antigen not merely on major histocompatibility complexes (MHC)-class II molecules to CD4+ T but also MHC-class I CD8+ cells. Immune responses against topically applied could be measured skin-draining lymph nodes. Skin barrier disruption or co-application adjuvants required maximal induction cell responses....
Incorporation of Ags by dendritic cells (DCs) increases when are targeted to endocytic receptors mAbs. We have previously demonstrated in the mouse that mAbs against C-type lectins administered intradermally taken up epidermal Langerhans (LCs), dermal Langerin(neg) DCs, and Langerin(+) DCs situ. However, relative contribution these skin DC subsets induction immune responses after Ag targeting has not been addressed vivo. show this study murine LCs transport injected lectin receptor...
Abstract Pseudomonas aeruginosa is a Gram‐negative bacterium causing morbidity and mortality in immuno‐compromised humans. It produces lectin, LecB, that considered major virulence factor, however, its impact on the immune system remains incompletely understood. Here we show LecB binds to endothelial cells human skin mice disrupts transendothelial passage of leukocytes vitro . impairs migration dendritic into paracortex lymph nodes leading reduced antigen‐specific T cell response. Under...
Murine tumor models that closely reflect human diseases are important tools to investigate carcinogenesis and immunity. The transgenic (tg) mouse strain tg(Grm1)EPv develops spontaneous melanoma due ectopic overexpression of the metabotropic glutamate receptor 1 (Grm1) in melanocytes. In present study, we characterized immune status functional properties cells tumor-bearing mice. Melanoma development was accompanied by a reduction percentages CD4(+) T including regulatory (Tregs) CD45(+)...
The role of plasmacytoid dendritic cells (PDCs) and type I interferons (IFNs) in rheumatoid arthritis (RA) remains a subject controversy. This study was undertaken to explore the contribution PDCs IFNs RA pathogenesis using various animal models PDC depletion monitor effect localized recruitment activation on joint inflammation bone damage.Mice with K/BxN serum-induced arthritis, collagen-induced human tumor necrosis factor transgene insertion were studied. Symptoms evaluated by visual...
Abstract Osteosarcoma (OS) is the most common primary bone cancer, where overall 5‐year surviving rate below 20% in resistant forms. Accelerating cures for those poor outcome patients remains a challenge. Nevertheless, several studies of agents targeting abnormal cancerous pathways have yielded disappointing results when translated into clinic because lack accurate OS preclinical modeling. So, any effort to design drug testing may consider all inter‐, intra‐, and extra‐tumoral...
Mannoside glycolipid conjugates are able to inhibit human immunodeficiency virus type 1 (HIV-1) trans-infection mediated by dendritic cells (DCs). The formed three building blocks: a linear or branched mannose head, hydrophilic linker, and 24-carbon lipid chain. We have shown that, even as single molecules, these compounds efficiently target mannose-binding lectins, such DC-specific ICAM-3-grabbing nonintegrin (DC-SIGN) important for HIV-1 transmission. With the goal optimize their...