A5031118170- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Atherosclerosis and Cardiovascular Diseases
- CAR-T cell therapy research
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Cancer Immunotherapy and Biomarkers
- Immune cells in cancer
- Single-cell and spatial transcriptomics
- interferon and immune responses
- vaccines and immunoinformatics approaches
- Virus-based gene therapy research
- Lymphatic System and Diseases
- Eosinophilic Esophagitis
- Cardiac Fibrosis and Remodeling
- Chemokine receptors and signaling
- Cell Adhesion Molecules Research
- Hematopoietic Stem Cell Transplantation
- Immune responses and vaccinations
- Monoclonal and Polyclonal Antibodies Research
Kantonsspital St. Gallen
2016-2025
University of St. Gallen
2012-2025
University Hospital of Zurich
1999-2025
University of Zurich
2011-2025
Institute of Immunology
2011-2022
Zero to Three
2019
QIMR Berghofer Medical Research Institute
2019
CeMM Research Center for Molecular Medicine
2019
Ludwig Cancer Research
2019
Addenbrooke's Hospital
2014
Many peripheral solid tumors such as sarcomas and carcinomas express tumor-specific antigens that can serve targets for immune effector T cells. Nevertheless, overall surveillance against seems relatively inefficient. We studied a s.c. sarcoma expressing characterized viral tumor antigen. Surprisingly, the cells were capable of inducing protective cytotoxic cell response if transferred single-cell suspension. However, they transplanted small pieces, readily grew. Tumor growth correlated...
Immunotherapy with checkpoint inhibitors targeting the PD-1 (programmed cell death 1) axis has brought notable progress in patients non-small lung cancer (NSCLC) and other cancers. However, autoimmune toxic effects are frequent poorly understood, making it important to understand pathophysiologic processes of adverse induced by inhibitor therapy.To gain mechanistic insight into skin anti-PD-1 treatment cancer.This prospective cohort study was conducted from July 1, 2016, December 31, 2018....
Coronaviruses are of veterinary and medical importance include highly pathogenic zoonotic viruses, such as SARS-CoV MERS-CoV. They known to efficiently evade early innate immune responses, manifesting in almost negligible expression type-I interferons (IFN-I). This evasion strategy suggests an evolutionary conserved viral function that has evolved prevent RNA-based sensing infection vertebrate hosts. Here we show the coronavirus endonuclease (EndoU) activity is key induction double-stranded...
Peptide mimicry breaks the heart Myocarditis, a prolonged chronic inflammation of muscle, can eventually progress to inflammatory cardiomyopathy, serious condition associated with failure. Activated T helper (T H ) cells that recognize myosin heavy chain 6–derived peptides are thought play central role in this pathogenesis. Using mouse model myocarditis, Gil-Cruz et al. found cardiac myosin–reactive initially primed by myosin-peptide mimics derived from commensal Bacteroides species gut (see...
Ectopic lymphoid structures form in a wide range of inflammatory conditions, including infection, autoimmune disease, and cancer. In the context this response can be beneficial for host: influenza A virus infection–induced pulmonary ectopic germinal centers give rise to more broadly cross-reactive antibody responses, thereby generating cross-strain protection. However, despite ubiquity their role both health little is known about mechanisms by which inflammation able convert peripheral...
Group 3 innate lymphoid cells (ILC3s) sense environmental signals and are critical for tissue integrity in the intestine. Yet, which sensed what receptors control ILC3 function remain poorly understood. Here, we show that ILC3s with a lymphoid-tissue-inducer (LTi) phenotype expressed G-protein-coupled receptor 183 (GPR183) migrated to its oxysterol ligand 7α,25-hydroxycholesterol (7α,25-OHC). In mice lacking Gpr183 or 7α,25-OHC, failed localize cryptopatches (CPs) isolated follicles (ILFs)....
Activation of autoreactive T cells can lead to autoimmune diseases such as insulin-dependent diabetes mellitus (IDDM). The initiation and maintenance IDDM by dendritic (DC), the most potent professional antigen-presenting cells, were investigated in transgenic mice expressing lymphocytic choriomeningitis virus glycoprotein (LCMV-GP) under control rat insulin promoter (RIP-GP mice). We show that after adoptive transfer DC constitutively immunodominant cytotoxic lymphocyte (CTL) epitope...
Vaccination with dendritic cells (DCs) presenting tumor antigens induces primary immune response or amplifies existing cytotoxic antitumor T cell responses. This study documents that treatment DCs may cause severe autoimmune disease when the are not tumor-specific but also expressed in peripheral nonlymphoid organs. Growing tumors such shared were, at least initially, strictly located outside of secondary lymphoid organs were successfully controlled by specific DC vaccination. However, was...
Attenuated viral vaccines can be generated by targeting essential pathogenicity factors. We report here the rational design of an attenuated recombinant coronavirus vaccine based on a deletion in coding sequence non-structural protein 1 (nsp1). In cell culture, nsp1 mouse hepatitis virus (MHV), like its SARS-coronavirus homolog, strongly reduced cellular gene expression. The effect MHV replication vitro and vivo was analyzed using encoding nsp1-coding sequence. mutant grew normally tissue...
Abstract In the lymphoid tissues, adaptive immune responses are initiated by interaction of interdigitating dendritic cells (IDC) with naive T cells. To understand this interplay better, we used mature Langerhans (mLC), migrating from human epidermis, as correlate IDC ex vivo to evaluate different effects tumor necrosis factor (TNF)‐α, TNF‐related activation protein (TRAP; CD40‐ligand) and interleukin‐10 (IL‐10) on induction or prevention apoptotic cell death in these Spontaneous decrease...
Infections with persistent viruses are a frequent cause of immunosuppression, autoimmune sequelae, and/or neoplastic disease. Plasmacytoid dendritic cells (pDCs) innate immune that produce type I interferon (IFN-I) and other cytokines in response to virus-derived nucleic acids. Persistent often depletion or functional impairment pDCs, but the role pDCs control these remains unclear. We used conditional targeting pDC-specific transcription factor E2-2 generate mice constitutively lack...
Smooth muscle cell (SMC) accumulation in the intima of vessels is a key event pathogenesis transplant atherosclerosis. The traditional hypothesis that SMCs lesion are derived from media donor vessel has been challenged by recent observations, but origin still not well established.Here, we use simplified model artery allografts transgenic mice to clearly identify source Aortic segments donated BALB/c allografted ROSA26 (C57B/6) expressing beta-galactosidase (gal) all tissues showed neointimal...
ABSTRACT The 3C-like proteinase (3CL pro ) of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is one the most promising targets for anti-SARS-CoV drugs due to its crucial role in viral life cycle. In this study, a database containing structural information more than 8,000 existing was virtually screened by docking approach identify potential binding molecules SARS-CoV 3CL . As target screening, both homology model and crystallographic structure pocket enzyme were used....