A5072766876- Immunotherapy and Immune Responses
- Nail Diseases and Treatments
- Antifungal resistance and susceptibility
- T-cell and B-cell Immunology
- Dermatology and Skin Diseases
- Fungal Infections and Studies
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Herbal Medicine Research Studies
- Psoriasis: Treatment and Pathogenesis
- Fungal Biology and Applications
- Histiocytic Disorders and Treatments
- CAR-T cell therapy research
- Laser Applications in Dentistry and Medicine
- Exercise and Physiological Responses
- Mosquito-borne diseases and control
- Infectious Diseases and Mycology
- Allergic Rhinitis and Sensitization
- vaccines and immunoinformatics approaches
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Probiotics and Fermented Foods
- Viral Infections and Vectors
- Pediatric health and respiratory diseases
- Bee Products Chemical Analysis
- NF-κB Signaling Pathways
University of Zurich
2015-2024
Innsbruck Medical University
2008-2014
ETH Zurich
2014
Mucosal infections with Candida albicans belong to the most frequent forms of fungal diseases. Host protection is conferred by cellular immunity; however, induction antifungal immunity not well understood. Using a mouse model oropharyngeal candidiasis (OPC) we show that interleukin-1 receptor (IL-1R) signaling critical for control at onset infection through its impact on neutrophils two levels. We demonstrate both recruitment circulating site and mobilization newly generated from bone marrow...
The opportunistic fungal pathogen Candida albicans frequently causes diseases such as oropharyngeal candidiasis (OPC) in immunocompromised individuals. Although it is well appreciated that the cytokine IL-17 crucial for protective immunity against OPC, cellular source and regulation of this during infection are still a matter debate. Here, we directly visualized production tongue experimentally infected mice, thereby demonstrating key expressed by three complementary subsets CD90+...
Abstract The receptor tyrosine kinase Flt3 and its ligand are crucial for dendritic cell (DC) homeostasis by activating downstream effectors including mammalian target of Rapamycin (mTOR) signalling. LAMTOR2 is a member the Ragulator/LAMTOR complex known to regulate mTOR extracellular signal-regulated activation on late endosome as well endosomal biogenesis. Here we show in mice that conditional ablation DCs results severe disturbance DC compartment caused accumulation surface. This an...
Significance Malassezia species are the main fungal components of mammalian skin microbiome and associated with a number disorders. Recently, has also been found in association Crohn’s disease pancreatic cancer. The elucidation molecular bases adaptation by is critical to understand its role as commensal pathogen. In this study we employed evolutionary, molecular, biochemical, structural analyses demonstrate that bacterially derived flavohemoglobins acquired through horizontal gene transfer...
Dendritic cells capture and process antigen present it to T lymphocytes in the lymphoid organs. of skin, including epidermal Langerhans cells, langerin(+) langerin(negative) dermal dendritic are ideally positioned take up pathogens that enter body through skin or vaccines administered into (intradermal) onto (epicutaneous) skin. The uptake properties have not thoroughly been studied yet. We therefore investigated fluorochrome-conjugated model ovalbumin (OVA) by mouse. OVA was readily taken...
The opportunistic fungal pathogen Candida albicans can cause invasive infections in susceptible hosts and the innate immune system, particular myeloid cell-mediated immunity, is critical for rapid protection host survival during systemic candidiasis. Using a mouse model of human disease, we identified novel role IL-23 antifungal defense. IL-23-deficient mice are highly to infection with C. albicans. We found that this results from drastic reduction all subsets cells infected kidney, which...
Langerhans cells, a subset of skin dendritic cells in the epidermis, survey peripheral tissue for invading pathogens. In recent functional studies it was proven that can present exogenous antigen not merely on major histocompatibility complexes (MHC)-class II molecules to CD4+ T but also MHC-class I CD8+ cells. Immune responses against topically applied could be measured skin-draining lymph nodes. Skin barrier disruption or co-application adjuvants required maximal induction cell responses....
Animal models are crucial for infectious disease research. They provide an important basis analyzing the full spectrum of interactions that occur between microbes and their host in vivo a tissue-specific manner. Pathogenic fungi increasingly recognized as serious threat humans exploiting such infection have greatly improved our understanding fungal pathogenicity. Species genus Malassezia most abundant human skin microbiota they also associated with development severe inflammatory disorders...
The fungal community of the skin microbiome is dominated by a single genus, Malassezia. Besides its symbiotic lifestyle at host interface, this commensal yeast has also been associated with diverse inflammatory diseases in humans and pet animals. Stable colonization maintained antifungal type 17 immunity. mechanisms driving Th17 responses to Malassezia remain, however, unclear. Here, we show that C-type lectin receptors Mincle, Dectin-1, Dectin-2 recognize conserved patterns cell wall induce...
Abstract APCs, such as dendritic cells (DC), can present glycolipid Ags on CD1d molecules to NKT cells. This interaction activates DC and cells, leading release of cytokines enhanced T cell responses. Thus, are currently being tested adjuvants for immunotherapy. We were interested in the murine skin with skin-draining lymph nodes. observed that all subsets expressed upon migration Moreover, able synthetic Ag α-galactosylceramide (α-GalCer) hybridoma DN32.D3. Intradermally injected α-GalCer...
West Nile Virus (WNV) is a mosquito-transmitted flavivirus which causes encephalitis especially in elderly and immunocompromised individuals. Previous studies have suggested the protective role of Toll-like receptor 3 (TLR3) pathway against WNV entry into brain, while non-structural protein 1 (NS1) interferes with TLR3 signaling pathway, besides being component viral genome replication machinery. In this study, we investigated whether immunization NS1 could protect neuroinvasion context...
Abstract Cytohesin‐interacting protein (Cytip) is induced during dendritic cell (DC) maturation and in T cells upon activation. It has also been shown to be involved the regulation of immune responses. Here, we evaluated functional consequences Cytip deficiency DCs using knockout (KO) mice. No difference DC subpopulations skin draining lymph nodes (LNs) was found between KO mice their wild‐type counterparts, excluding a role development. To investigate function vivo, used...