A5083698836- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Malaria Research and Control
- Adrenal and Paraganglionic Tumors
- Virus-based gene therapy research
- Cytomegalovirus and herpesvirus research
- Cervical Cancer and HPV Research
- Polyomavirus and related diseases
- Cancer, Hypoxia, and Metabolism
- Hormonal Regulation and Hypertension
- SARS-CoV-2 and COVID-19 Research
- Parvovirus B19 Infection Studies
- COVID-19 Clinical Research Studies
- Neuroendocrine Tumor Research Advances
- CRISPR and Genetic Engineering
- Cancer Research and Treatments
- MicroRNA in disease regulation
- Insect symbiosis and bacterial influences
- Virology and Viral Diseases
- Herpesvirus Infections and Treatments
- Genomics and Phylogenetic Studies
- Genital Health and Disease
- Pituitary Gland Disorders and Treatments
- Neuroblastoma Research and Treatments
- Animal Virus Infections Studies
University of Padua
2016-2025
University of Pavia
2022
University of Southampton
2021
Regione del Veneto
2012-2021
Military Medical Academy
2016
Santa Maria Nuova Hospital
2016
Fondazione Edmund Mach
2014
Veneto Institute of Molecular Medicine
2012
Azienda Ospedaliera di Padova
2009-2012
Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies
2012
Abstract On the 21 st of February 2020 a resident municipality Vo’, small town near Padua, died pneumonia due to SARS-CoV-2 infection 1 . This was first COVID-19 death detected in Italy since emergence Chinese city Wuhan, Hubei province 2 In response, regional authorities imposed lockdown whole for 14 days 3 We collected information on demography, clinical presentation, hospitalization, contact network and presence nasopharyngeal swabs 85.9% 71.5% population Vo’ at two consecutive time...
We report the isolation of infectious Zika virus (ZIKV) in cell culture from saliva a patient who developed febrile illness after returning Dominican Republic to Italy, January 2016. The had prolonged shedding viral RNA and urine, at higher load than blood, for up 29 days symptom onset. Sequencing ZIKV genome showed relatedness with strains Latin America.
Although antibody levels progressively decrease following SARS-CoV-2 infection, the immune memory persists for months. Thus, individuals who naturally contracted are expected to develop a more rapid and sustained response COVID-19 vaccines than naïve individuals. In this study, we analyzed dynamics of BNT162b2 mRNA vaccine in six healthcare workers March 2020, comparison nine control subjects without previous infection. The was well tolerated by both groups, with no significant difference...
Zika virus (ZIKV) is a mosquito-borne flavivirus that emerged recently as global health threat, causing pandemic in the Americas. ZIKV infection mostly causes mild disease, but linked to devastating congenital birth defects and Guillain-Barré syndrome adults. The high level of cross-reactivity among flaviviruses their cocirculation has complicated serological approaches differentially detect dengue (DENV) infections, accentuating urgent need for specific sensitive test. We previously...
Mosquito-borne West Nile virus (WNV) infection is benign in most individuals but can cause encephalitis <1% of infected individuals. We show that ∼35% patients hospitalized for WNV disease (WNVD) six independent cohorts from the EU and USA carry auto-Abs neutralizing IFN-α and/or -ω. The prevalence these antibodies highest with (∼40%), silent as low general population. odds ratios WNVD relative to those without them population range 19.0 (95% CI 15.0–24.0, P value <10–15) only...
Neurological manifestations are common in COVID-19, the disease caused by SARS-CoV-2. Despite reports of SARS-CoV-2 detection brain and cerebrospinal fluid COVID-19 patients, it is still unclear whether virus can infect central nervous system, which neuropathological alterations be ascribed to viral tropism, rather than immune-mediated mechanisms. Here, we assess 24 patients 18 matched controls who died due pneumonia/respiratory failure. Aside from a wide spectrum alterations,...
West Nile virus (WNV) outbreaks in birds, humans, and livestock have occurred multiple areas Europe had a significant impact on animal human health. The patterns of emergence spread WNV are very different from those the US understanding these important for guiding preparedness activities.
The natural course of adrenal incidentalomas and the risk that such lesions evolve toward hormonal hypersecretion or malignancy are still under evaluation. Of 246 consecutive patients with incidentaloma studied at our institution in last 15 yr, 91 underwent surgery. remaining patients, a group 75 (52 females 23 males; median age, 56 yr; range, 19–77 yr) incidentally discovered asymptomatic masses (60 unilateral bilateral; diameter, 2.5 cm; 1.0–5.6) was enrolled an endocrine morphological...
A hypercoagulable state and an increased incidence of thromboembolic complications are reported in Cushing's syndrome. The is related to increase plasma clotting factors, especially Factor VIII von Willebrand factor complex, impairment fibrinolytic capacity. Retrospective analysis postoperative events a large group patients with syndrome, including 75 (group 1) evaluated the period from 1972–1981 not receiving anticoagulants, 232 2), 1982–2000. Patients 1 underwent routine hemostatic...
We describe the dynamics of Zika virus (ZIKV) infection in a man his early 40s who developed fever and rash after returning from Haiti to Italy, January 2016. Follow-up laboratory testing demonstrated detectable ZIKV RNA plasma up day 9 symptom onset urine saliva days 15 47, respectively. Notably, persistent shedding was semen, still at 181 onset.
Human papillomaviruses (HPVs) are agents of the most common sexually transmitted diseases in females and males. Precise data about presence, mechanism infection clinical significance HPV male reproductive tract especially sperm not available. Here we show that can infect human sperm, it localizes at equatorial region head through interaction between capsid protein L1 syndecan-1. Sperm transfected with E6/E7 genes exposed to capable penetrate oocyte transfer virus into oocytes, which viral...
Detection of West Nile virus (WNV) RNA in urine has been anecdotally described and proposed for the diagnosis WNV infection. This study reports routine use real-time reverse-transcription polymerase chain reaction detection to support infection during large outbreak that occurred northeastern Italy 2012. Fourteen 32 patients (43.8%) with symptomatic infection, defined as neuroinvasive disease fever, had detectable at time diagnosis, a higher rate load longer than blood. was less frequent (2...
To improve our understanding of the natural history Zika virus (ZIKV) infection in humans, we described dynamics ZIKV RNA shedding different body fluids and antibody responses patients with acute infection. Twenty-nine adults travel-associated 1 case sexual transmission were enrolled followed up weekly testing blood, urine, saliva, semen samples testing. was detected plasma, saliva 57%, 93.1%, 69.2% participants, estimated median times to clearance 11.5 days (interquartile range [IQR] 6–24...
Autophagy is a primordial eukaryotic pathway, which provides the immune system with multiple mechanisms for elimination of invading pathogens including Mycobacterium tuberculosis (Mtb). As consequence, Mtb has evolved different strategies to hijack autophagy process. Given crucial role human primary dendritic cells (DC) in host immunity control, we characterized Mtb-DC interplay by studying contribution cellular microRNAs (miRNAs) post-transcriptional regulation related genes. From...
Abnormal levels of microRNA (miR)-155, which regulate inflammation and immune responses, have been demonstrated in the colonic mucosa patients with inflammatory bowel diseases (IBD), although its role disease pathophysiology is unknown. We investigated miR-155 acquisition maintenance an activated phenotype by intestinal myofibroblasts (IMF), a key cell population contributing to mucosal damage IBD. IMF were isolated from biopsies healthy controls, ulcerative colitis (UC) Crohn's (CD)...