A5072833956- Hormonal and reproductive studies
- Sperm and Testicular Function
- Per- and polyfluoroalkyl substances research
- Effects and risks of endocrine disrupting chemicals
- Reproductive Biology and Fertility
- Cervical Cancer and HPV Research
- Sexual Differentiation and Disorders
- Estrogen and related hormone effects
- Angiogenesis and VEGF in Cancer
- Vitamin D Research Studies
- Sexual function and dysfunction studies
- Birth, Development, and Health
- Toxic Organic Pollutants Impact
- Pregnancy-related medical research
- Ovarian function and disorders
- Bone health and osteoporosis research
- Genital Health and Disease
- Reproductive Health and Technologies
- Peripheral Neuropathies and Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Microbial metabolism and enzyme function
- Growth Hormone and Insulin-like Growth Factors
- Testicular diseases and treatments
- Autoimmune Neurological Disorders and Treatments
- Stress Responses and Cortisol
University of Padua
2016-2025
University of Verona
2002-2006
Azienda Ospedaliera Universitaria Integrata Verona
2003-2005
Endothelial dysfunction seems to be the first step of atherosclerotic process. In past few years, it has been demonstrated that injured endothelial monolayer is restored by a premature pool circulating progenitor cells (PCs) and more mature one PCs (EPCs). Even though there increasing evidence estrogens play beneficial role on EPCs and, even if debated, cardiovascular system, less known about androgens.Our objective was evaluate levels in men with hypogonadotropic hypogonadism (HH) effect...
Context: The adipose tissue (AT), which is an endocrine organ, linked to several metabolic abnormalities. Undercarboxylated osteocalcin (ucOCN) regulates insulin and adiponectin secretion. Objective: Our objective was investigate the involvement of OCN in obesity evaluate, vitro ex vivo, role AT modulation this circuit. Design, Patients, Setting: This transversal study involved 83 male subjects, divided according World Health Organization body mass index classification, evaluated at Padova's...
Mutations in the CYP2R1 gene, highly expressed testis and encoding vitamin D 25-hydroxylase, result a deficiency defective calcium homeostasis leading to rickets.Our aim was investigate expression pathological samples relate this metabolism testiculopathic patients. DESIGN, PATIENTS, SETTING: Testis for vitro study 98 young men were transversally evaluated at Padova's Center Male Gamete Cryopreservation.CYP2R1 mRNA protein production by quantitative RT-PCR, Western blot analysis,...
STUDY QUESTIONWhat are the dynamics of zinc (Zn) trafficking in sperm, at testicular, epididymal and ejaculate levels?
Phthalate plasticizers and heavy metals are widely recognized to be pollutants that interfere with key developmental processes such as masculinization. We investigated the release of phthalates in coffee brewed from packed single-serve containers made different types materials: metal, biodegradable plastics. detected GC–MS small amounts phthalates, below tolerated daily risks levels, all coffees prepared capsules. Specifically, Di (2-ethyl-hexyl)-phthalate DiBP: Diisobuthyl-pthalate were...
Abstract In this study we aimed to evaluate the effect on reproductive outcome of HPV vaccination in male subjects infertile couples with semen infection. single-center study, retrospectively enrolled 151 detection semen, attending our Hospital Unit Andrology between January 2013 and June 2015, counseled receive adjuvant vaccination. Seventy-nine accepted (vaccine group) whilst 72 did not (control group). Our protocol follow-up, viral clearance, consisted analysis, INNO-LiPA FISH for cells...
Perfluoro-alkyl substances (PFAS), particularly perfluoro-octanoic acid (PFOA), are persisting environmental chemicals showing bioaccumulation in human tissues. Recently, exposure to PFAS has been associated with increased prevalence of cardiovascular diseases (CVDs). However, a causal role atherosclerosis pathogenesis is under-investigated. Here, we investigated the effect PFOA on platelets' function, key player process. accumulation platelets was evaluated by liquid chromatography-mass...
Abstract Perfluoroalkyl substances (PFAS) are a class of compounds used in industry and consumer products. Perfluorooctanoic acid (PFOA) is the predominant form human samples has been shown to induce severe health consequences, such as neonatal mortality, neurotoxicity, immunotoxicity. Toxicological studies indicate that PFAS accumulate bone tissues cause altered development. Epidemiological have reported an inverse relationship between health, however associated mechanisms still unexplored....
Perfluoroalkyl substances (PFASs) are synthetic chemicals widely used in industrial and consumer products. The environmental spreading of PFASs raises concerns for their impact on human health. In particular, the bioaccumulation humans due to exposure has been reported also total brain samples PFAS associated with neurodevelopmental disorders. this study we aimed investigate specific different areas. Our data major accumulation brainstem region, which is richly populated by dopaminergic...
The current trend dealing with the production of per- and polyfluoroalkyl substances (PFASs) involves shifting toward branched short-chain fluorinated compounds known as new-generation PFASs. A key aspect to be clarified, address adverse health effects associated exposure PFASs, is their binding mode human serum albumin (hSA), most abundant protein in plasma. In this study, we investigated interaction between hSA two representative namely, HPFO-DA C6O4. In-solution studies revealed that both...
Testosterone (T) treatment has recently been shown to induce an increase in the number of endothelial progenitor cells (EPCs) through a possible effect on bone marrow. Hypogonadotrophic hypogonadal (HH) men have low circulating EPCs that significantly after T treatment. Moreover, expression androgen receptor (AR) demonstrated by immunohistochemistry these cells, suggesting might also direct EPC function. In present study we investigated and function AR human vitro androgens Design patients...
BACKGROUNDHuman papillomavirus (HPV) infection has been demonstrated in the sperm of a large percentage sexually active males and is associated with an impairment parameters, particular negative impact on motility, suggesting possible role male infertility. Conventional selection techniques have low efficiency removing HPV.
Klinefelter Syndrome (KS) is the most common abnormality of sex chromosomes (47,XXY) and represents first genetic cause male infertility. Mechanisms leading to KS testis degeneration are still not completely defined but considered be mainly result germ cells loss. In order unravel molecular basis global dysfunction in patients, we performed a transcriptome analysis on biopsies obtained from 6 azoospermic non-mosaic patients 3 control subjects.The found that, compared controls, showed...
Vitamin D accumulates in adipose tissue (AT), and vitamin deficiency is frequent obesity. We hypothesize that trafficking of altered dysfunctional AT. Fifty-four normal-weight 67 obese males were recruited a prospective study randomly assigned to supplementation with 50 µg/wk 25-hydroxyvitamin-D3 or 150 D3 for 1 year, raising dosage by 50% if sufficiency [serum >50 nmol/L], was not achieved at 6 months; 97 subjects completed the study. quantified HPLC-MS control insulin-resistant (IR) 3T3-L1...
The molecular bases of sperm thermotaxis, the temperature-oriented cell motility, are currently under investigation. Thermal perception relies on a subclass transient receptor potential [TRP] channels, whose member TRPV1 is acknowledged as heat sensing receptor. Here we investigated involvement in human thermotaxis. We obtained semen samples from 16 normozoospermic subjects attending an infertility survey programme, testis biopsies 6 patients with testicular germ cancer and fine needle...
Perfluoroalkyl substances (PFASs) raise concerns about their environmental accumulation. Experimental data have suggested that PFASs interfere with bone metabolism from the early stages of life. However, mechanisms underlying this association are unclear. The aim study was to evaluate possible between exposure PFAS and vitamin D (VitD), serum calcium parathyroid hormone (PTH) levels in subjects residing high-exposure area Veneto Region Italy. In cross-sectional observational study, 1174 who...