A5006849677- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Hormonal and reproductive studies
- Pregnancy-related medical research
- Pharmacological Effects and Toxicity Studies
- Sexual Differentiation and Disorders
- Chemokine receptors and signaling
- Neurobiology and Insect Physiology Research
- Immune cells in cancer
- Biofuel production and bioconversion
- Endometrial and Cervical Cancer Treatments
- Neuroendocrine regulation and behavior
- Olfactory and Sensory Function Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA and protein synthesis mechanisms
- RNA Research and Splicing
- Biochemical Analysis and Sensing Techniques
- Bone health and treatments
- Sperm and Testicular Function
- Genetic factors in colorectal cancer
- Reproductive System and Pregnancy
- RNA Interference and Gene Delivery
- Phosphodiesterase function and regulation
- Estrogen and related hormone effects
Istituto Oncologico Veneto
2018-2019
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2019
University of Padua
2008-2018
Abstract Background Qualitative alterations or abnormal expression of microRNAs (miRNAs) in colon cancer have mainly been demonstrated primary tumors. Poorly overlapping sets oncomiRs, tumor suppressor miRNAs and metastamiRs linked with distinct stages the progression colorectal cancer. To identify changes both miRNA gene levels among normal mucosa, liver metastasis samples, to classify into functional networks, this work profiles 158 samples from 46 patients were analysed. Results Most had...
Mutations in the CYP2R1 gene, highly expressed testis and encoding vitamin D 25-hydroxylase, result a deficiency defective calcium homeostasis leading to rickets.Our aim was investigate expression pathological samples relate this metabolism testiculopathic patients. DESIGN, PATIENTS, SETTING: Testis for vitro study 98 young men were transversally evaluated at Padova's Center Male Gamete Cryopreservation.CYP2R1 mRNA protein production by quantitative RT-PCR, Western blot analysis,...
// Lisa Perilli 1,* , Caterina Vicentini 3,* Marco Agostini 4,5 Silvia Pizzini 6 Pizzi 7 Edoardo D'Angelo 3 Stefania Bortoluzzi Susanna Mandruzzato 1,2 Enzo Mammano 4 Massimo Rugge Donato Nitti Aldo Scarpa 3,8 Matteo Fassan and Paola Zanovello 1 Oncology Immunology Section, Department of Surgery, Gastroenterology, University Padua, Italy 2 Istituto Oncologico Veneto (IOV), IRCCS, ARC-NET Research Centre, Verona, Surgery Section 5 di Ricerca Pediatrica - Citta' della Speranza, Biology,...
Young men with mutations in the gene for INSL3 receptor (Relaxin family peptide 2, RXFP2) are at risk of reduced bone mass and osteoporosis. Consistent human phenotype, analyses Rxfp2(-/-) mice showed decreased volume, alterations trabecular bone, mineralizing surface, formation, osteoclast surface. The aim this study was to elucidate INSL3/RXFP2 signaling pathways targets osteoblasts.Alkaline phosphatase (ALP) production, protein phosphorylation, intracellular calcium, expression,...
Alternative splicing (AS) is a common mechanism which creates diverse RNA isoforms from single gene, potentially increasing protein variety. Growing evidence suggests that this closely related to cancer progression. In study, whole transcriptome analysis was performed with GeneChip Human exon 1.0 ST Array 80 samples comprising 23 normal colon mucosa, 30 primary colorectal and 27 liver metastatic specimens 46 patients, identify AS events in Differentially expressed genes exons were estimated...
For fertilization to occur in mammals, ejaculated spermatozoa must reach the egg which, following ovulation has moved from ovary into Fallopian tube. Two active mechanisms of guidance have been shown mammals: thermotaxis and chemotaxis. The identity most human chemoattractants is unknown, herein we tested if SDF1 (chemokine stromal cell-derived factor-1) its pathway involved We found that expressed oocytes, endometrium follicular fluid, as well specific receptor CXCR4 CXC motif 4) head...
miR-182-5p (miR-182) is an oncogenic microRNA (miRNA) found in different tumor types and one of the most up-regulated miRNA colorectal cancer (CRC). Although this expressed early steps development, its role driving tumorigenesis unclear. The effects miR-182 silencing on transcriptomic profile were investigated using two CRC cell lines characterized by vivo biological behavior, MICOL-14h-tert line (dormant upon transfer into immunodeficient hosts) tumorigenic variant, MICOL-14tum. Apoptosis...
Abstract Working Hypothesis: Mutations in the CYP2R1 gene, highly expressed testis and encoding vitamin D 25-hydroxylase, result a deficiency defective calcium homeostasis leading to rickets. Objective: Our aim was investigate expression pathological samples relate this metabolism testiculopathic patients. Design, Patients, Setting: Testis for vitro study 98 young men were transversally evaluated at Padova's Center Male Gamete Cryopreservation. Methods: mRNA protein production by...
Qualitative alterations or abnormal expression of microRNAs (miRNAs) in colorectal cancer has mainly been demonstrated primary tumors. The miRNA profiles 78 samples from 46 patients were analyzed to identify changes level among normal colon mucosa, tumor and liver metastasis samples. Using this dataset, we describe the interplay groups regulating pathways that are important for development. Here details contents quality controls clinical data associated with study published by Pizzini...
Abstract Background : miR-182-5p (miR-182) is an oncogenic microRNA (miRNA) in different tumor types and one of the most up-regulated miRNA colorectal cancer (CRC). Although this expressed already early steps development, its role driving tumorigenesis unclear. Methods The effects miR-182 silencing on transcriptomic profile were investigated using two CRC cell lines characterized by vivo biological behavior, MICOL-14 h-tert line (dormant upon transfer into immunodeficient hosts) tumorigenic...
Abstract Background : miR-182-5p (miR-182) is an oncogenic microRNA (miRNA) in different tumor types and one of the most up-regulated miRNA colorectal cancer (CRC). Although this expressed already early steps development, its role driving tumorigenesis unclear. Methods The effects miR-182 silencing on transcriptomic profile were investigated using two CRC cell lines characterized by vivo biological behavior, MICOL-14 h-tert line (dormant upon transfer into immunodeficient hosts) tumorigenic...