A5083493477- Hormonal and reproductive studies
- Sexual function and dysfunction studies
- Sexual Differentiation and Disorders
- Sperm and Testicular Function
- Growth Hormone and Insulin-like Growth Factors
- Pharmacology and Obesity Treatment
- Testicular diseases and treatments
- Effects and risks of endocrine disrupting chemicals
- Per- and polyfluoroalkyl substances research
- Prostate Cancer Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Chemical Analysis and Environmental Impact
- Adrenal and Paraganglionic Tumors
- Toxic Organic Pollutants Impact
- Neuroendocrine Tumor Research Advances
- Neuroblastoma Research and Treatments
- Genital Health and Disease
- Healthcare and Venom Research
- Ovarian function and disorders
- Thermoregulation and physiological responses
- Drug-Induced Adverse Reactions
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Vector-Borne Animal Diseases
- Prostate Cancer Treatment and Research
Puigvert Foundation
2020-2024
Universitat Autònoma de Barcelona
2020-2024
Neuroscience Institute
2021
University of Padua
2017-2021
Azienda Ospedaliera di Padova
2020
Abstract In this study we aimed to evaluate the effect on reproductive outcome of HPV vaccination in male subjects infertile couples with semen infection. single-center study, retrospectively enrolled 151 detection semen, attending our Hospital Unit Andrology between January 2013 and June 2015, counseled receive adjuvant vaccination. Seventy-nine accepted (vaccine group) whilst 72 did not (control group). Our protocol follow-up, viral clearance, consisted analysis, INNO-LiPA FISH for cells...
Traditional risk factors used to assess cardiovascular miss a significant population who are indeed at for future cardiac events. Erectile dysfunction (ED) is an emerging marker disease (CVD) and major adverse events (MACE), especially in young middle-aged men with vasculogenic ED. Cavernous arteries morphological alterations penile colour doppler ultrasound (P-CDU) find ED.We investigated the possible relationship between cavernous P-CDU assessment MACE.We conducted retrospective cohort...
Objective. Type 5 phosphodiesterase inhibitors (PDE5i) are efficient drugs used for treatment of erectile dysfunction (ED); however, a large discontinuation rate due to major side effects is reported. The aim this study was evaluate the possible improvement sildenafil (Sild) pharmacokinetics associated sublingual administration new available oro-dispersible film (ODF), compared both tablet (ODT) and coated (FCT) as original per os formulation. Methods. In vitro disaggregation test,...
PSA screening has led to an over-diagnosis of prostate cancer (PCa) and unnecessary biopsies benign conditions due its low specificity. Consequently, more accurate, preferentially non-invasive, tests are needed. We aim evaluate the potential semen sEV (small extracellular vesicles) tsRNAs (tRNA-derived small RNAs) as PCa indicators. Initially, following a literature review in OncotRF database high-throughput RNA-sequencing studies tissue together with sncRNA profile sEVs, we selected four...
During the last decade, disclosure of systemic effects osteocalcin (OCN) in its undercarboxylated form contributed to switch concept bone from a merely structural apparatus fully endocrine organ involved regulation functions. Since that time, role OCN as osteokine has been more and widened appreciated detailed by major use animal models, starting original function extracellular matrix Gla-protein spanning protective towards weight gain, insulin sensitivity glucose homeostasis, anabolic...
Milk-proteins, besides lactose, stimulate insulin and incretin secretion. Although whey-proteins (WP) are more efficient than casein (Cas) in hormone secretion, the effects of reversal (WP/Cas) ratio whole-milk poorly known.
Testicular germ cell tumors (TGCTs) are prevalent in males of reproductive age. Among the available therapeutic choices, pelvic radiotherapy (RT) and simple surveillance (SURV) usually pursued. However, RT is considered to have life-threatening effects on testicular functions. In this study we sought clarify issue by evaluating sperm parameters sex hormones 131 TGCTs RT-treated-patients at both baseline (T0) 12 (T1) 24 months (T2) follow-up. An age-matched group 61 SURV patients served as...
Abstract GPRC6A is acknowledged as a major regulator of energy metabolism and male fertility through the action undercarboxylated osteocalcin (ucOCN), representing possible therapeutic target. We recently showed that sex hormone-binding globulin (SHBG) binds to likely involvement 141–161 domain. To confirm this model, here we investigated binding agonist activity SHBG(141–161) domain-peptide (SHBG ) on GPRC6A. The SHBG downstream dissociation from G αi (GDP) protein was computationally...
There is increasing data in favour of follicle-stimulating hormone (FSH) therapy patients with oligo-asthenozoospermia and normal-range gonadotropins order to increase sperm count above all motility. Some studies showed an improvement DNA fragmentation spontaneous pregnancy. Recently, biosimilar FSH has been marketed the same indications. We performed a retrospective multicentric case-control study involving 147 asthenozoospermic between 18 45 years age. A total 97 were treated 150 UI three...
We analyzed the efficacy of penile low-intensity extracorporeal shockwave treatment for erectile dysfunction (ED) combined with cavernous artery disease (CAD). ED was evaluated by International Index Erectile Function, subdividing patients into mild and moderate/severe forms. CAD assessed using color Doppler ultrasonography. Patients (n = 111) a positive outcome after treatment, based upon minimal clinically important difference ED, were followed up 3 months 6 months. found significant mean...
Abstract Background The androgen receptor (AR) is a nuclear receptor, encoded by the AR gene on X chromosome. Within first exon of gene, two short tandem repeats (STR), CAG and GGC, are source polymorphism in population. Therefore, high‐throughput methods for screening , such as next‐generation sequencing (NGS), sought after; however, data generated NGS limited availability bioinformatics tools. Here, we evaluated accuracy tool HipSTR detecting quantify within gene. Method 228 infertile men...
Type V-phosphodiesterase-inhibitors (PDE5i) are the first choice drugs in treatment of erectile dysfunction (ED), being effective 60–70% patients. However, approximately 50% patients per year discontinue with PDE5i after reporting poor drug efficacy or major adverse reactions (ADR). To identify early markers efficacy/safety for ED PDE5i, basal clinical characteristics patients, integrated metabolomics analysis serum and urine genomic data, were here correlated occurrence ADR upon...
Abstract Introduction In the diagnostic workup of erectile dysfunction (ED) Nocturnal Penile Tumescence and Rigidity test (NPTR) is being used less because its inconvenience but also in part intrinsic limits this test. particular, NPTR has been considered very useful to diagnose psychogenic ED when it positive (normal) informative negative (pathological) high incidence false negatives. Other tests have suggested better an organic ED, especially dynamic Colour-Doppler Ultrasound (PCDU) study...
Erectile dysfunction (ED) can stem from various organic and functional causes but is often linked to vascular health cardiovascular disease. Limited data exist on how disease markers correlate with objective ED tests like the Nocturnal Penile Tumescence Rigidity (NPTR) test Color Doppler Ultrasound (PCDU).
Weight control through lifestyle interventions represents a suitable strategy to avoid the metabolic, endocrine, and reproductive comorbidities associated with overweight obesity. Reduced testosterone (T) levels are worsening factor in males. However, prognostic parameters of long-term weight loss not readily available. Here, we tested value early variations anthropometric hormonal parameters, focus on ultrasound stratigraphy (US) reduction body mass index (BMI) nutritional...