A5068243517- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Cancer Research and Treatments
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Neuroblastoma Research and Treatments
- Cancer Treatment and Pharmacology
- Epigenetics and DNA Methylation
- PI3K/AKT/mTOR signaling in cancer
- Genetic Associations and Epidemiology
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Surgical Treatments
- Cancer-related gene regulation
- Genetic factors in colorectal cancer
- Acute Myeloid Leukemia Research
- Genomic variations and chromosomal abnormalities
- Liver physiology and pathology
- Colorectal and Anal Carcinomas
- BRCA gene mutations in cancer
- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Computational Drug Discovery Methods
- Mycobacterium research and diagnosis
- Radiomics and Machine Learning in Medical Imaging
Città della Speranza Foundation
2015-2023
University of Padua
1994-2022
Candiolo Cancer Institute
2007-2014
University of Turin
2009-2014
Radboud University Nijmegen
2011-2014
Radboud University Medical Center
2014
Cancer Genetics (United States)
2013
IFOM
2009-2013
Sidney Kimmel Cancer Center
2013
Janssen (Belgium)
2013
Abstract Monoclonal antibodies (mAbs) against the extracellular domain of epidermal growth factor receptor (EGFR) have been introduced for treatment metastatic colorectal cancer (mCRC). We reported recently that increased copy number EGFR can predict response to anti-EGFR mAbs and patients might be selected based on number. Here, we show mutations activating RAS/RAF signaling pathway are also predictive prognostic indicators in mCRC patients, being inversely correlated with mAbs. In cellular...
EGF receptor (EGFR)-targeted monoclonal antibodies are effective in a subset of metastatic colorectal cancers. Inevitably, all patients develop resistance, which occurs through emergence KRAS mutations approximately 50% the cases. We show that amplification MET proto-oncogene is associated with acquired resistance tumors do not during anti-EGFR therapy. Amplification locus was present circulating tumor DNA before relapse clinically evident. Functional studies activation confers to therapy...
BackgroundGenetic and epigenetic profiling of glioblastomas has provided a comprehensive list altered cancer genes which only O6-methylguanine-methyltransferase (MGMT) methylation is used thus far as predictive marker in clinical setting. We investigated the prognostic significance genetic alterations glioblastoma patients.
Abstract A recent systematic sequence analysis of well-annotated human protein coding genes or consensus sequences led to the identification 189 displaying somatic mutations in breast and colorectal cancers. Based on their mutation prevalence, a subset these was identified as cancer candidate (CAN) they could be potentially involved cancer. We evaluated mutational profiles 19 CAN highly aggressive tumors: glioblastoma, melanoma, pancreatic carcinoma. Among other changes, we found novel...
European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.
We used an approach that we term ancestry-shift refinement mapping to investigate association, originally discovered in a GWAS of Chinese population, between rs2046210[T] and breast cancer susceptibility. The locus is on 6q25.1 proximity the C6orf97 estrogen receptor α (ESR1) genes. identified panel SNPs are correlated with rs2046210 Chinese, but not necessarily so other ancestral populations, genotyped them case∶control samples Asian, European, African origin, total 10,176 cases 13,286...
The spectrum of somatic mutation the most aggressive forms neuroblastoma is not completely determined. We sought to identify potential cancer drivers in clinically neuroblastoma.Whole exome sequencing was conducted on 17 germline and tumor DNA samples from high-risk patients with adverse events within 36 months diagnosis (HR-Event3) mutations deep targeted 134 genes selected initial screening additional 48 pairs (62.5% HR-Event3 patients), tumors human-derived cell lines.We revealed 22...
// Edoardo D'Angelo 1, 2 , Matteo Fassan 3 Isacco Maretto 1 Salvatore Pucciarelli Carlo Zanon 4 Maura Digito Massimo Rugge Donato Nitti Marco Agostini 2, 5 Department of Surgical, Oncological and Gastroenterological Sciences, University Padua, Italy Nanoinspired Biomedicine Laboratory, Institute Pediatric Research, Fondazione Città della Speranza, Medicine (DIMED), Surgical Pathology & Cytopathology Unit, Neuroblastoma Research Institute, Nanomedicine, The Methodist Hospital Houston, Texas,...
The occurrence of oncogenic alleles can display striking tissue specificity. For example KRAS mutations are very frequent in pancreatic cancers but relatively rare melanomas. opposite is true for BRAF mutations. Somatic the gene encoding phosphatidylinositol 3-kinase (PI3KCA) catalytic subunit, PIK3CA, occur at high frequency many solid cancers. We have examined whether PI3K (exons 9 and 20) might exhibit gender and/or By examining large cohorts breast colorectal affecting both men women we...
Glioblastoma is a highly malignant brain tumor for which no cure available. To identify new therapeutic targets, we performed mutation analysis of kinase genes in glioblastoma. Database mining and literature search identified 76 kinases that have been found to be mutated at least twice multiple cancer types before. Among those selected 34 analysis. We also included IDH1, IDH2, PTEN, TP53 NRAS, are known considerable frequencies In total, 174 exons 39 113 glioblastoma samples from 109...
Preoperative chemoradiotherapy is widely used to improve local control of disease, sphincter preservation and survival in patients with locally advanced rectal cancer. Patients enrolled the present study underwent preoperative chemoradiotherapy, followed by surgical excision. Response was evaluated according Mandard's Tumor Regression Grade (TRG). TRG 3, 4 5 were considered as partial or no response while 1 2 complete response. From pretherapeutic biopsies 84 carcinomas available for...
// Sanja Aveic 1 , Marcella Pantile Anke Seydel Maria Rosaria Esposito Carlo Zanon Gary Li 2 Gian Paolo Tonini Neuroblastoma Laboratory, Pediatric Research Institute, Città della Speranza, Padua, Italy Ignyta Inc., San Diego, California, USA Correspondence to: Aveic, e-mail: s.aveic@irpcds.org Keywords: neuroblastoma, autophagy, ALK inhibitors; drug combination, entrectinib Received: July 21, 2015 Accepted: December 22, Published: 28, ABSTRACT (NB) is a threatening childhood malignancy. Its...
HIF-1α has been suggested to interplay with Wnt signaling components in order activate a neuronal differentiation process both normal brain and glioblastoma (GBM).Based on these data, we explored the molecular mechanisms underlying observed capability of GBM cells acquire phenotype upon stimulation how microenvironment, particularly hypoxia, modulates this process.Methods: here, employment ChIP-seq techniques together co-immunoprecipitation approaches allowed reconstruct interactions...