Ingileif Jónsdóttir
A5049232805- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Genetic Associations and Epidemiology
- Respiratory viral infections research
- Asthma and respiratory diseases
- Osteoarthritis Treatment and Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Immune Response and Inflammation
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Immune Cell Function and Interaction
- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- IL-33, ST2, and ILC Pathways
- Growth Hormone and Insulin-like Growth Factors
- Genomics and Rare Diseases
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
- Pediatric health and respiratory diseases
- Glycosylation and Glycoproteins Research
- Cytokine Signaling Pathways and Interactions
- COVID-19 Clinical Research Studies
- Epigenetics and DNA Methylation
deCODE Genetics (Iceland)
2016-2025
University of Iceland
2016-2025
National University Hospital of Iceland
2014-2024
Reykjavík University
2002-2024
Amgen (Germany)
2016-2023
RMIT University
2023
University of British Columbia
2020
Directorate of Health
2020
Faculty (United Kingdom)
2016
Finnish Institute of Occupational Health
2011
Sequence variants, including the ε4 allele of apolipoprotein E, have been associated with risk common late-onset form Alzheimer's disease. Few rare variants affecting disease found.
BackgroundDuring the current worldwide pandemic, coronavirus disease 2019 (Covid-19) was first diagnosed in Iceland at end of February. However, data are limited on how SARS-CoV-2, virus that causes Covid-19, enters and spreads a population.MethodsWe targeted testing to persons living who were high risk for infection (mainly those symptomatic, had recently traveled high-risk countries, or contact with infected persons). We also carried out population screening using two strategies: issuing...
Little is known about the nature and durability of humoral immune response to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).We measured antibodies in serum samples from 30,576 persons Iceland, using six assays (including two pan-immunoglobulin [pan-Ig] assays), we determined that appropriate measure seropositivity was a positive result both pan-Ig assays. We tested 2102 collected 1237 up 4 months after diagnosis by quantitative polymerase-chain-reaction (qPCR)...
Detailed knowledge of how diversity in the sequence human genome affects phenotypic depends on a comprehensive and reliable characterization both sequences variation. Over past decade, insights into this relationship have been obtained from whole-exome sequencing or whole-genome large cohorts with rich data1,2. Here we describe analysis 150,119 individuals UK Biobank3. This constitutes set high-quality variants, including 585,040,410 single-nucleotide polymorphisms, representing 7.0% all...
Human IgG3 displays the strongest effector functions of all IgG subclasses but has a short half-life for unresolved reasons. Here we show that binds to IgG-salvage receptor (FcRn), FcRn-mediated transport and rescue is inhibited in presence IgG1 due intracellular competition between IgG3. We reveal this occurs because single amino acid difference at position 435, where an arginine instead histidine found other subclasses. While R435 increases binding FcRn neutral pH, it decreases acidic...
The human leukocyte antigen (HLA) haplotype DRB1*15:01 is the major risk factor for multiple sclerosis (MS). Here, we find that hypomethylated and predominantly expressed in monocytes among carriers of DRB1*15:01. A differentially methylated region (DMR) encompassing HLA-DRB1 exon 2 particularly affected displays methylation-sensitive regulatory properties vitro. Causal inference Mendelian randomization provide evidence HLA variants mediate MS via changes DMR modify expression. Meta-analysis...
Lipoprotein(a) [Lp(a)] is a causal risk factor for cardiovascular diseases that has no established therapy. The attribute of Lp(a) affects not established. Low levels have been associated with type 2 diabetes (T2D). This study investigated whether conferred by molar concentration or apolipoprotein(a) [apo(a)] size, and the relationship between T2D causal. was case-control 143,087 Icelanders genetic information, including 17,715 coronary artery disease (CAD) 8,734 T2D. used measured...
High-throughput proteomics platforms measuring thousands of proteins in plasma combined with genomic and phenotypic information have the power to bridge gap between genome diseases. Here we performed association studies Olink Explore 3072 data generated by UK Biobank Pharma Proteomics Project
Nonalcoholic fatty liver (NAFL) and its sequelae are growing health problems. We performed a genome-wide association study of NAFL, cirrhosis hepatocellular carcinoma, integrated the findings with expression proteomic data. For we utilized 9,491 clinical cases proton density fat fraction extracted from 36,116 magnetic resonance images. identified 18 sequence variants associated NAFL 4 cirrhosis, found rare, protective, predicted loss-of-function in MTARC1 GPAM, underscoring them as potential...