Sigurjón A. Guðjónsson

ORCID: 0000-0001-9314-7412
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About
Contact & Profiles
Research Areas
  • Genetic Associations and Epidemiology
  • Genomics and Rare Diseases
  • Epigenetics and DNA Methylation
  • Cancer Genomics and Diagnostics
  • Genomics and Chromatin Dynamics
  • Genomic variations and chromosomal abnormalities
  • Cancer-related Molecular Pathways
  • Genomics and Phylogenetic Studies
  • Gene expression and cancer classification
  • Genetic Syndromes and Imprinting
  • RNA modifications and cancer
  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • Evolution and Genetic Dynamics
  • Genetic factors in colorectal cancer
  • Molecular Biology Techniques and Applications
  • Bladder and Urothelial Cancer Treatments
  • Bioinformatics and Genomic Networks
  • Advanced Proteomics Techniques and Applications
  • RNA and protein synthesis mechanisms
  • Immune Cell Function and Interaction
  • Protein Tyrosine Phosphatases
  • Connective tissue disorders research
  • Genetics and Neurodevelopmental Disorders
  • BRCA gene mutations in cancer

deCODE Genetics (Iceland)
2015-2025

Michigan Medicine
2024

Amgen (Germany)
2022-2023

American Academy of Dermatology
2016

Park Terrace Care Center
2016

Amgen (United States)
2015

Amgen (Canada)
2015

University of Michigan
2010

Genetic diversity arises from recombination and de novo mutation (DNM). Using a combination of microarray genotype whole-genome sequence data on parent-child pairs, we identified 4,531,535 crossover recombinations 200,435 DNMs. The resulting genetic map has resolution 682 base pairs. Crossovers exhibit mutagenic effect, with overrepresentation DNMs within 1 kilobase crossovers in males females. In females, higher rate is observed up to 40 kilobases crossovers, particularly for complex which...

10.1126/science.aau1043 article EN Science 2019-01-25
Bjarni V. Halldórsson Hannes P. Eggertsson Kristjan H. S. Moore Hannes Hauswedell Ögmundur Eiríksson and 74 more Magnús Ö. Úlfarsson Gunnar Pálsson Marteinn T. Hardarson Ásmundur Oddsson Brynjar Ö. Jensson Snædís Kristmundsdóttir Brynja D. Sigurpalsdottir Ólafur Andri Stefánsson Doruk Beyter Guillaume Holley Vinicius Tragante Arnaldur Gylfason Pall I. Olason Florian Zink Margret Asgeirsdottir Sverrir T. Sverrisson Brynjar Sigurdsson Sigurjón A. Guðjónsson Gunnar Sigurðsson Gísli H. Halldórsson Garðar Sveinbjörnsson Kristján Norland Unnur Styrkársdóttir Droplaug N. Magnúsdóttir Steinunn Snorradóttir Kári Kristinsson Emilia Sobech Helgi Jónsson Árni Jón Geirsson Ísleifur Ólafsson Pálmi V. Jónsson Ole Birger Pedersen Christian Erikstrup Søren Brunak Sisse Rye Ostrowski Steffen Andersen Karina Banasik Kristoffer Sølvsten Burgdorf Maria Didriksen Khoa Manh Dinh Christian Erikstrup Daníel F. Guðbjartsson Thomas Hansen Henrik Hjalgrim Gregor B. E. Jemec Poul Jennum Pär I. Johansson Margit Anita Hørup Larsen Susan Mikkelsen Kasper Nielsen Mette Nyegaard Sisse Rye Ostrowski Susanne Gjørup Sækmose Erik Sørensen Unnur Þorsteinsdóttir Mie Topholm Brun Henrik Ullum Thomas Werge Guðmar Þorleifsson Frosti Jónsson Páll Melsted Ingileif Jónsdóttir Þórunn Rafnar Hilma Hólm Hreinn Stefánsson Jona Saemundsdottir Daníel F. Guðbjartsson Ólafur Þ. Magnússon Gísli Másson Unnur Þorsteinsdóttir Agnar Helgason Hákon Jónsson Patrick Sulem Kári Stéfansson

Detailed knowledge of how diversity in the sequence human genome affects phenotypic depends on a comprehensive and reliable characterization both sequences variation. Over past decade, insights into this relationship have been obtained from whole-exome sequencing or whole-genome large cohorts with rich data1,2. Here we describe analysis 150,119 individuals UK Biobank3. This constitutes set high-quality variants, including 585,040,410 single-nucleotide polymorphisms, representing 7.0% all...

10.1038/s41586-022-04965-x article EN cc-by Nature 2022-07-20
Simon Stacey Patrick Sulem Áslaug Jónasdóttir Gísli Másson Jūlı́us Guðmundsson and 95 more Daníel F. Guðbjartsson Ólafur Þ. Magnússon Sigurjón A. Guðjónsson Bárður Sigurgeirsson Kristin Thorisdottir Rafn Ragnarsson Kristrún R. Benediktsdóttir Bjørn A. Nexø Anne Tjønneland Kim Overvad Péter Rudnai Eugen Gurzău Kvetoslava Koppová Kari Hemminki Cristina Corredera Victoria Fuentelsaz Pilar Grasa Sebastián Navarrete Fernando Fuertes María Dolores García-Prats Enrique Sanambrosio Angeles Panadero Ana De Juan Almudena García Fernando Rivera Dolores Planelles Vincent Soriano Celia Requena Katja K.H. Aben Michelle M. van Rossum R.G.H.M. Cremers Inge M. van Oort Dick-Johan van Spronsen Jack A. Schalken Wilbert H.M. Peters Brian T. Helfand Jenny Donovan Freddie C. Hamdy D. Badescu O. Codreanu Mariana Jinga Irma Eva Csiki Vali Constantinescu P Badea Ioan Nicolae Mateș Daniela Dinu Adrian Constantin Dana Mateș Sjöfn Kristjánsdóttir Bjarni A. Agnarsson Eiríkur Jónsson Rósa B. Barkardóttir Guðmundur Einarsson Fridbjörn Sigurdsson Páll Helgi Möller Tryggvi Stefánsson Trausti Valdimarsson Oskar T. Johannsson Helgi Sigurðsson Þorvaldur Jónsson Jón G. Jónasson Laufey Tryggvadóttír Terri Rice Helen M. Hansen Yuanyuan Xiao Daniel H. Lachance Brian Patrick O’Neill Matthew Kosel Paul A. Decker Guðmar Þorleifsson Hrefna Johannsdottir Hafdís T. Helgadóttir Ásgeir Sigurðsson Valgerður Steinthórsdóttir Annika Lindblom Robert S. Sandler Temitope O. Keku Karina Banasik Torben Jørgensen Daniel R. Witte Torben Hansen Oluf Pedersen Viorel Jinga David E. Neal William J. Catàlona Margaret Wrensch John K. Wiencke Robert B. Jenkins Eduardo Nagore Ulla Vogel Lambertus A. Kiemeney Rajiv Kumar José Mayordomo Jón Ólafsson Augustine Kong

10.1038/ng.926 article EN Nature Genetics 2011-09-25
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