Maria Didriksen
A5021739668- Restless Legs Syndrome Research
- Genetic Associations and Epidemiology
- Parkinson's Disease Mechanisms and Treatments
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- Sleep and Wakefulness Research
- Blood groups and transfusion
- Long-Term Effects of COVID-19
- Hemoglobinopathies and Related Disorders
- SARS-CoV-2 and COVID-19 Research
- Blood donation and transfusion practices
- Attention Deficit Hyperactivity Disorder
- Migraine and Headache Studies
- Nail Diseases and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Psychosomatic Disorders and Their Treatments
- Health disparities and outcomes
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Treatment of Major Depression
- Circadian rhythm and melatonin
- Cardiovascular Syncope and Autonomic Disorders
- Health, Environment, Cognitive Aging
- Hidradenitis Suppurativa and Treatments
- BRCA gene mutations in cancer
- Biomedical Research and Pathophysiology
Copenhagen University Hospital
2017-2025
Rigshospitalet
2017-2025
University of Copenhagen
2021-2025
Lundbeck (Denmark)
2024
University of Tartu
2024
University of Exeter
2024
VID Specialized University
2022
University of Oslo
2022
Oslo University Hospital
2022
University of Edinburgh
2022
Detailed knowledge of how diversity in the sequence human genome affects phenotypic depends on a comprehensive and reliable characterization both sequences variation. Over past decade, insights into this relationship have been obtained from whole-exome sequencing or whole-genome large cohorts with rich data1,2. Here we describe analysis 150,119 individuals UK Biobank3. This constitutes set high-quality variants, including 585,040,410 single-nucleotide polymorphisms, representing 7.0% all...
<h2>Summary</h2><h3>Background</h3> Long-term mental and physical health consequences of COVID-19 (long COVID) are a persistent public concern. Little is still known about the long-term non-hospitalised patients with varying illness severities. Our aim was to assess prevalence adverse symptoms among individuals diagnosed in general population by acute infection severity up 16 months after diagnosis. <h3>Methods</h3> This observational follow-up study included seven prospectively planned...
Back pain is a common and debilitating disorder with largely unknown underlying biology. Here we report genome-wide association study of back using diagnoses assigned in clinical practice; dorsalgia (119,100 cases, 909,847 controls) intervertebral disc (IDD) (58,854 922,958 controls). We identify 41 variants at 33 loci. The most significant (OR
Although the persistence of physical symptoms after SARS-CoV-2 infection is a major public health concern, evidence from large observational studies beyond one year post diagnosis remain scarce. We aimed to assess prevalence in relation acute illness severity up more than 2-years COVID-19.This multinational study included 64,880 adult participants Iceland, Sweden, Denmark, and Norway with self-reported data on COVID-19 April 2020 August 2022. compared 15 symptoms, measured by Patient Health...
Abstract Migraine is a complex neurovascular disease with range of severity and symptoms, yet mostly studied as one phenotype in genome-wide association studies (GWAS). Here we combine large GWAS datasets from six European populations to study the main migraine subtypes, aura (MA) without (MO). We identified four new MA-associated variants (in PRRT2 , PALMD ABO LRRK2 ) classified 13 MO-associated variants. Rare effects highlight three genes. A rare frameshift variant brain-expressed confers...
Abstract Background The emerging use of biomarkers in research and tailored care introduces a need for information about the association between basic demographics lifestyle factors revealing expectable concentrations healthy individuals while considering general demographic differences. Methods A selection 47 biomarkers, including markers inflammation vascular stress, were measured plasma samples from 9876 Danish Blood Donor Study participants. Using regression models, we examined sex, age,...
Polygenic risk scores (PRSs) are expected to play a critical role in precision medicine. Currently, PRS predictors generally based on linear models using summary statistics, and more recently individual-level data. However, these mainly capture additive relationships limited data modalities they can use. We developed deep learning framework (EIR) for prediction which includes model, genome-local-net (GLN), specifically designed large-scale genomics The supports multi-task learning, automatic...
Previous studies have reported Blood type O to confer a lower risk of SARS-CoV-2 infection, while secretor status and other blood groups been suspected similar effect as well.To determine whether any influence testing positive for SARS-CoV-2, COVID-19 severity, or prolonged COVID-19, we used large cohort 650,156 Danish donors with varying available data ABO, Rh, Colton, Duffy, Diego, Dombrock, Kell, Kidd, Knops, Lewis, Lutheran, MNS, P1PK, Vel, Yt. Of these, 36,068 tested whereas 614,088...
There is a need for better recognition and more extensive research into menstrual migraine (MM) in the general population, revision of diagnostic criteria MM warranted to move field forward. Increased understanding crucial improving clinical care, diagnosis, therapy MM.To assess characteristics MM, including severity treatment response, propose new pure menstrually related migraine.This case-control study Danish individuals with migraine. All completed 105-item validated questionnaire, sent...
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BACKGROUND Blood donors have an increased risk of low hemoglobin (Hb) levels due to iron deficiency. Therefore, knowledge genetic variants associated with Hb could facilitate individualized donation intervals. We previously reported three specific single‐nucleotide polymorphisms that were ferritin in blood donors. In this study, we investigated the effect these on 15,567 Danish STUDY DESIGN AND METHODS studied participants Donor Study. The examined genes and 1) TMPRSS6 , involved regulation...
Genotypes causing pregnancy loss and perinatal mortality are depleted among living individuals therefore difficult to find. To explore genetic causes of recessive lethality, we searched for sequence variants with deficit homozygosity 1.52 million from six European populations. In this study, identified 25 genes harboring protein-altering a strong (10% or less predicted homozygotes). Sequence in 12 the cause Mendelian disease under mode inheritance, two dominant mode, but remaining 11 have...