A5028402121- Osteoarthritis Treatment and Mechanisms
- Spine and Intervertebral Disc Pathology
- Cell Adhesion Molecules Research
- Connective tissue disorders research
- Musculoskeletal pain and rehabilitation
- RNA Research and Splicing
- Developmental Biology and Gene Regulation
- Bone Metabolism and Diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer-related molecular mechanisms research
- Hedgehog Signaling Pathway Studies
- Prostate Cancer Treatment and Research
- Congenital heart defects research
- Fibroblast Growth Factor Research
- TGF-β signaling in diseases
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Orthopaedic implants and arthroplasty
- Animal Genetics and Reproduction
- Medical Imaging and Analysis
- Renal and related cancers
- Marine animal studies overview
- Molecular Biology Techniques and Applications
- Tendon Structure and Treatment
University of Hong Kong
2016-2025
Chinese University of Hong Kong
2012-2025
Stavros Niarchos Foundation
2022-2023
Joachim Herz Stiftung
2022-2023
HKU-Pasteur Research Pole
2009-2022
Biogipuzkoa Health Research Institute
2012
Centro de Investigación Biomédica en Red
2012
Spanish National Cancer Research Centre
2012
Institute of Cancer Research
2010
University of Liverpool
2010
In Brief Study Design. A cross-sectional population study of magnetic resonance imaging (MRI) changes. Objective. To examine the pattern and prevalence lumbar spine MRI changes within a southern Chinese their relationship with back pain. Summary Background Data. Previous studies on pain have used populations asymptomatic individuals or patients presenting sciatica. Thus, intervertebral disc degeneration is not known. Methods. Lumbar MRIs were obtained in 1043 volunteers between 18 to 55...
Significance The possibility that terminally differentiated hypertrophic chondrocytes could survive and become osteoblasts in vivo has been debated for more than a century. We show can the cartilage-to-bone transition osteocytes during endochondral bone formation repair. Our discovery provides basis conceptual change of chondrocyte-to-osteoblast lineage continuum, with new insights into process formation, ontogeny cells, homeostasis. Furthermore, our findings have implications current...
Despite the high prevalence of intervertebral disc disease, little is known about changes in cells and their regenerative potential with ageing degeneration. Here we identify populations progenitor that are Tie2 positive (Tie2+) disialoganglioside 2 (GD2+), nucleus pulposus from mice humans. These form spheroid colonies express type II collagen aggrecan. They clonally multipotent differentiated into mesenchymal lineages induced reorganization tissue when transplanted non-obese...
Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants 11 osteoarthritis phenotypes, 52 of which have not been the disease before. We report thumb spine differences in genetic effects between weight-bearing non-weight-bearing joints. sex-specific early age-at-onset loci. integrate functional genomics data from...
Sox2 is a high-mobility transcription factor that one of the earliest markers developing inner ear prosensory domains. In humans, mutations in SOX2 cause sensorineural hearing loss and function study mice showed required for formation cochlea. However, specific roles have not been determined. Here we illustrate dynamic role as an early permissive domain followed by mutually antagonistic relationship with Atoh1, bHLH protein necessary hair cell development. We demonstrate decreased levels...
Pbx1 and a subset of homeodomain proteins collaboratively bind DNA as higher-order molecular complexes with unknown consequences for mammalian development. contributions were investigated through characterization Pbx1-deficient mice. mutants died at embryonic day 15/16 severe hypoplasia or aplasia multiple organs widespread patterning defects the axial appendicular skeleton. An obligatory role in limb axis was apparent from malformations proximal skeletal elements, but distal structures...
The mouse alpha 1(II) collagen gene has been isolated and a 5' portion of the which low homology to other genes was used study pattern expression during embryogenesis. In situ hybridization studies show that in mouse, like chick, is expressed chondrogenic tissues advance chondrocyte differentiation. early embryogenesis at 9.5 days both cranial mesenchyme destined for chondrocranium, sclerotome somites, 12.5 primordia hyoid laryngeal cartilage. Type II transcripts were found all axial...
Cartilage and endochondral bone development require SOX9 activity to regulate chondrogenesis, chondrocyte proliferation, transition a non-mitotic hypertrophic state. The restricted reciprocal expression of the collagen X gene, Col10a1, in chondrocytes Sox9 immature epitomise precise spatiotemporal control gene as progress through phases differentiation, but how this is achieved not clear. Here, we have identified regulatory element upstream Col10a1 that enhances its vivo. In chondrocytes,...
Abstract SOX9 [sex-determining region Y (SRY)-box 9 protein], a high mobility group box transcription factor, plays critical roles during embryogenesis and its activity is required for development, differentiation, lineage commitment in various tissues including the intestinal epithelium. Here, we present functional clinical data of broadly important role tumorigenesis. was overexpressed wide range human cancers, where expression correlated with malignant character progression. Gain copy...
There are conflicting views on whether collagen X is a purely structural molecule, or regulates bone mineralization during endochondral ossification. Mutations in the human α1(X) gene (COL10A1) Schmid metaphyseal chondrodysplasia (SMCD) suggest supportive role. But mouse (Col10a1) null mutants were previously reported to show no obvious phenotypic change. We have generated deficient mice, which shows that deficiency does consequences partly resemble SMCD, such as abnormal trabecular...
In protein folding and secretion disorders, activation of endoplasmic reticulum (ER) stress signaling (ERSS) protects cells, alleviating that would otherwise trigger apoptosis. Whether the stress-surviving cells resume normal function is not known. We studied in vivo impact ER terminally differentiating hypertrophic chondrocytes (HCs) during endochondral bone formation. transgenic mice expressing mutant collagen X as a consequence 13-base pair deletion Col10a1 (13del), misfolded α1(X) chains...
Lumbar disc degeneration (LDD) is associated with both genetic and environmental factors affects many people worldwide. A hallmark of LDD loss proteoglycan water content in the nucleus pulposus intervertebral discs. While some determinants have been reported, etiology largely unknown. Here we report findings from linkage association studies on a total 32,642 subjects consisting 4,043 cases 28,599 control subjects. We identified carbohydrate sulfotransferase 3 (CHST3), an enzyme that...
Dysregulation of tissue development pathways can contribute to cancer initiation and progression. In murine embryonic prostate epithelia, the transcription factor SOX9 is required for proper development. this study, we examined a role in mouse human. Pten Nkx3.1 mutant mice, cells with increased levels appeared within epithelia at early stages neoplasia, higher expression correlated progression all disease. transgenic overexpression cell proliferation without inducing hyperplasia. mice that...