A5100461393- Respiratory Support and Mechanisms
- Cardiac Ischemia and Reperfusion
- Structural Health Monitoring Techniques
- Infrastructure Maintenance and Monitoring
- Spine and Intervertebral Disc Pathology
- Intensive Care Unit Cognitive Disorders
- Respiratory and Cough-Related Research
- Neonatal Respiratory Health Research
- Real-time simulation and control systems
- EEG and Brain-Computer Interfaces
- Cardiac Arrest and Resuscitation
- Spinal Cord Injury Research
- Phonocardiography and Auscultation Techniques
- Parkinson's Disease Mechanisms and Treatments
- Advanced Sensor and Control Systems
- Neuroscience of respiration and sleep
- Asphalt Pavement Performance Evaluation
- Anesthesia and Neurotoxicity Research
- Vitamin D Research Studies
- Music and Audio Processing
- Airway Management and Intubation Techniques
- Cardiac Fibrosis and Remodeling
- Traditional Chinese Medicine Analysis
- Industrial Technology and Control Systems
- HVDC Systems and Fault Protection
Beihang University
2006-2024
China Medical University
2017-2024
Sichuan University
2019-2024
Sun Yat-sen University Cancer Center
2022-2024
Sun Yat-sen University
2022-2024
Southwest Medical University
2024
Liaoning Cancer Hospital & Institute
2024
Qingdao University
2024
Shandong University
2024
Northwest Normal University
2023
Pulmonary surfactant is a lipoprotein complex lining the alveolar surface to decrease tension and facilitate inspiration. Surfactant deficiency often seen in premature infants also children adults with respiratory distress syndrome. Mechanical stretch of type 2 epithelial (AT2) cells during lung expansion primary physiological factor that stimulates secretion; however, it unclear whether there mechanosensor dedicated for this process. Here we show loss mechanosensitive channels TMEM63A...
Lumbar disc degeneration (LDD) is associated with both genetic and environmental factors affects many people worldwide. A hallmark of LDD loss proteoglycan water content in the nucleus pulposus intervertebral discs. While some determinants have been reported, etiology largely unknown. Here we report findings from linkage association studies on a total 32,642 subjects consisting 4,043 cases 28,599 control subjects. We identified carbohydrate sulfotransferase 3 (CHST3), an enzyme that...
It has proved that the auscultation of respiratory sound advantage in early diagnosis. Various methods have been raised to perform automatic analysis reduce subjective diagnosis and physicians' workload. However, these highly rely on quality database. In this work, we developed first open-access paediatric database, SPRSound. The database consists 2,683 records 9,089 events from 292 participants. Accurate label is important achieve a good prediction for adventitious classification problem. A...
To investigate the vaginal and gut microbes changes during carcinogenesis of cervical auxiliary diagnostic value. effect microbiome-specific metabolites butyric on cancer cells. We studied 416 16S rRNA sequencing data 116 data. Reads were processed using VSEARCH. used Shannon index, Chao1 Simpson diversity β Linear discriminant analysis Effect Size (LEfSe), co-abundance network Kyoto Encyclopedia Genes Genomes (KEGG) enrichment to explore microbiome differences between groups. constructed...
To determine the cost-effectiveness of treatment with caffeine compared placebo for apnea prematurity in infants birth weights less than 1250 g, from through 18 to 21 months' corrected age.We undertook a retrospective economic evaluation cost per survivor without neurodevelopmental impairment by using individual-patient data Caffeine Apnea Prematurity clinical trial (N = 1869). We included direct medical costs either insurance payer or hospital but excluded parents and society, such as lost...
The Rho-kinase (ROCK) plays an important role in the pathogenesis of heart injury. Recent cellular and molecular biology studies indicated a pivotal RhoA/ROCK cascade many aspects cardiovascular function such as failure, cardiac hypertrophy, ventricular remodeling following myocardial infarction. However, signal transduction its down-stream signaling pathways remains elusive, mechanism ROCK-mediated isoproterenol (ISO)-induced failure is still not thoroughly understood. In present study, we...
Respiratory sounds reveal important information of the lungs patients. However, analysis lung depends significantly on medical skills and diagnostic experience physicians is a time-consuming process. The development an automatic respiratory sound classification system based machine learning would, therefore, be beneficial. In this study, 705 signals (240 crackles, 260 rhonchi, 205 normal sounds) were acquired from 130 We found that similarities between original wavelet decomposed reflected...
Context Rosmarinic acid (RosA), a natural poly-phenolic compound isolated from variety of Labiatae herbs, has been reported to have range biological effects.Objective To investigate the cardioprotective effects RosA against myocardial ischaemia/reperfusion (I/R) injury.Materials and methods Male C57BL/6J mice were given (100 mg/kg) via intragastric administration. After 1 week administration, subjected 30 min/24 h I/R injury. The randomly subdivided into 4 groups: Vehicle, RosA, Vehicle +...
Lung cancer is one of the most common causes brain metastases and always associated with poor prognosis. We investigated immunophenotypes primary lung tumors paired metastases, as well in synchronous group (patients upon initial diagnosis) metachronous developed during course their disease). RNA sequencing eighty-six samples from 43 patients was conducted to analyze tumor immune microenvironment. Our data revealed that matched compared exhibited reduced infiltrating lymphocytes (TILs), a...
•BCBM genomic profiling is similar to that of the PTs: both have high mutation frequencies in TP53 and PIK3CA.•TMB TILs were relatively low BCBMs ∼8% had TMB.•Actionable GAs additional actionable undetected matched samples detected 94% 31% BCBMs. BackgroundBreast cancer brain metastasis (BCBM) a crucial issue treatment breast associated with poor prognosis. Therefore, novel therapeutic targets are urgently needed clinical practice. In this study, we aimed identify potential metastases (BMs)...
It is important to continuously monitor our respiratory system prevent us from suffering respiratory-releated diseases. This demands for an automatic sounds software speed up diagnosis and reduce the workload of physicians. In IEEE BioCAS 2022 conference, we have organized first grand challenge on sound classification using paediatric (SPRSound). event has invited 45 teams with more than 100 open source entries top 5 are present their works in 2022.
Efficient automatic segmentation of multi-level (i.e. main and branch) pulmonary arteries (PA) in CTPA images plays a significant role clinical applications. However, most existing methods concentrate only on PA or branch separately ignore efficiency. Besides, there is no public large-scale dataset focused segmentation, which makes it highly challenging to compare the different methods. To benchmark algorithms, we organized first \textbf{P}ulmonary \textbf{AR}tery \textbf{SE}gmentation...
Non aqueous phase liquid (NAPL) pollution exists in porous media such as soil. SVE technology can be used to remove this However, few domestic and international studies have paid attention the changes of soil temperature field, which we believe useful information optimize layout heating wells. In research established partial differential equations heat transfer using COMSOL multi-field coupling tool simulate field distribution change internal process obtain effective area with time under...