A5101867319- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Nerve injury and regeneration
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Heavy Metal Exposure and Toxicity
- Boron Compounds in Chemistry
- Neuroscience and Neuropharmacology Research
- Anesthesia and Sedative Agents
- Neurogenesis and neuroplasticity mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Glaucoma and retinal disorders
- Aluminum toxicity and tolerance in plants and animals
- Arsenic contamination and mitigation
- Sirtuins and Resveratrol in Medicine
- Mosquito-borne diseases and control
- Medicinal Plants and Bioactive Compounds
- Infrared Thermography in Medicine
- Inflammasome and immune disorders
- Retinal Development and Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Redox biology and oxidative stress
- Amyotrophic Lateral Sclerosis Research
- Corneal Surgery and Treatments
China Three Gorges University
2023
Yichang Central People's Hospital
2023
Nantong University
2019-2021
Shantou University
2005-2021
Shantou University Medical College
2005-2021
Fudan University
2021
Central South University
2019
Xiangya Hospital Central South University
2009-2019
Chinese University of Hong Kong
2007-2016
South University
2011-2012
To investigate the effect of ciliary neurotrophic factor (CNTF) and brain-derived (BDNF) on retinal ganglion cell (RGC) survival nitric oxide synthase (NOS) expression in retina during early phase optic nerve (ON) injury, to examine whether intraperitoneal application NOS scavenger nitro-l-arginine (l-NA) could protect injured RGCs.RGCs were retrogradely labeled with granular blue 3 days before ON was intraorbitally transected. RGC examined 1 week after transection intraocular injection CNTF...
Abstract Amyotrophic lateral sclerosis (ALS) is a devastating fatal neurodegenerative disease with no cure. Receptor-interacting protein kinase 1 (RIPK1) has been proposed to mediate pathogenesis of ALS. Primidone identified as an old drug that can also inhibit RIPK1 kinase. We conducted drug-repurposing biomarker study primidone inhibitor using SOD1 G93A mice and ALS patients. treated showed significant delay symptomatic onset improved motor performance. One-hundred-sixty-two participants...
Disease vectors such as mosquitoes and ticks play a major role in the emergence re-emergence of human animal viral pathogens. Compared to mosquitoes, however, much less is known about antiviral responses ticks. Here we showed that Asian longhorned ( Haemaphysalis longicornis ) produced predominantly 22-nucleotide virus-derived siRNAs (vsiRNAs) response severe fever with thrombocytopenia syndrome virus (SFTSV, an emerging tick-borne virus), Nodamura (NoV), or Sindbis (SINV) acquired by blood...
Abstract The immune response after neural injury influences the survival and regenerative capacity of neurons. In primary visual pathway, previous studies have described beneficial effects macrophages T‐cells in promoting axonal regeneration some rat strains. However, contributions specific cell populations to these responses been unclear. adult Fischer (F344) rats, we confirm prior reports that intravitreal macrophage activation promotes retinal ganglion cells (RGCs) greatly enhances...
To investigate the incidence of awareness during general anesthesia and analyze risk factors in anesthetic practice patient populations.A total 2 300 patients who underwent were included. Perioperative data drugs collected prospectively. Patients interviewed twice postoperatively with same structured questionnaire. Each was classified into categories as no awareness, possible awareness.Twenty-one (0.91%) definitely reported another 205 (8.91%) awareness. Few required psychological...
To investigate retinal ganglion cell (RGC) survival after optic nerve injury in calorie-restricted (CR) rats, and analyze the potential role of Sirtuins.Ten-month old male Sprague-Dawley rats (n=14) were divided into calorie restricted ad libitum (AL) groups. In CR group (n=7), denied access to food every other day. Animals AL (n=7) had free food. PN-ON grafting was carried out on right eyes all subjects 5 months feeding. Three weeks postoperatively, retina samples collected, half which...
Excessive necroptosis contributes to the pathogenesis of several inflammatory and neurodegenerative diseases. Here, using a high-throughput screening approach, we investigated anti-necroptosis effects piperlongumine, an alkaloid isolated from long pepper plant, in vitro mouse model systemic response syndrome (SIRS).A natural compound library was screened for cellular. The underlying mechanism action top candidate piperlongumine explored by quantifying marker phosphorylated...
Inflammation after acute CNS injury plays a dual role. The interplay between immune cells and inflammatory mediators is critical to the outcome of injured neurons. Microglia/macrophages are first sensors regulators response. We previously found that enhancement macrophages on neuron survival does not persist in thymectomized rats. How T lymphocytes interact benefit fully elucidated. To this point, we introduce characterize cell-retina co-culture model mimics recruitment peripheral at site....
Abstract Systemic inflammatory response syndrome (SIRS), at least in part driven by necroptosis, is characterized life‐threatening multiple organ failure. Blocking the progression of SIRS and consequent dysfunction challenging. Receptor‐interacting serine/threonine protein kinase 1 (RIPK1) an important cell death mediator, making it a potential treatment target several diseases. Here, using drug repurposing approach, we show that inhibiting RIPK1 also effective for SIRS. We performed...
To investigate the effect of SB203580, a p38MAPK specific inhibitor, on ropivacaine-induced cytotoxicity in PC12 cells. Methods: cells were divided into three groups: normal group (Group N), cultured for 48 h; ropivacaine R), with 15 mmol/L hydrochloride ropivacaine+SB203580 R+S), plus 10 μmol/L SB203580 h. The cell survival rates detected by MTT assay. protein levels cleaved caspase-3, phosphor-p38 (p-p38) and cystolic cytochrome C (Cyt C) Western blotting. Results: Compared Group N, number...
Sirtuins, comprised of seven members, protect cells from injury, possibly through different roles. In this study, we used two young rat optic nerve injury models to analyze the changes in Sirts 1–7 at time points better understand role sirtuins during injury. Twelve-week-old adult male F344 rats (total n=42) were divided randomly into groups. One group was subjected cut (ON-cut) and other a peripheral nerve-optic graft (PN-ON graft) on left eye. At 1 3 days 1, 2, 4 weeks, euthanized retinas...
Objective To investigate the roles of endothelial nitric oxide synthase (eNOS) and phosphoinositide-3 kinase/protein kinase B (PI3K/Akt) pathway in neuroprotection remote ischemic postconditioning (RIPoC) on global cerebral ischemia/reperfusion (I/R) injury rats. Methods One hundred male adult SD rats weighing 200 g-250 g were randomly divided into 5 groups (n=20 each):group sham,group I/R,group I/R+RIPoC,group L-NAME+I/R+RIPoC,group LY+I/R+RIPoC.Global I/R was induced by four-vessel...
Objective To investigate the effects of remote ischemic postconditioning (RIPoC) on global cerebral ischemia-reperfusion (I/R) injury in rats.Methods One hundred and twenty-eight male adult SD rats weighing 200-250 g were randomly divided into 4 groups ( n =32 each):sham operation group (group S),group I/R,group I/R + RIPoC RI/R ).Global was induced by four-vessel occlusion.Group received 3 cycles 15 min reperfusion followed ischemia bilateral femoral arteries at beginning reperfusion.The...