A5023304268- Cancer, Lipids, and Metabolism
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Metabolism and Genetic Disorders
- Amino Acid Enzymes and Metabolism
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Landslides and related hazards
- Cryospheric studies and observations
- Bioactive Compounds and Antitumor Agents
- ATP Synthase and ATPases Research
- Pancreatic function and diabetes
- Fire effects on ecosystems
- Mitochondrial Function and Pathology
- Microbial Metabolic Engineering and Bioproduction
- Neuroblastoma Research and Treatments
- Biochemical and Molecular Research
- Cell death mechanisms and regulation
- T-cell and Retrovirus Studies
- PI3K/AKT/mTOR signaling in cancer
- Genetic Associations and Epidemiology
- Inflammasome and immune disorders
- Psoriasis: Treatment and Pathogenesis
- Herpesvirus Infections and Treatments
Peking University
2023-2025
Peking University Sixth Hospital
2023-2025
Zhongyuan University of Technology
2024
Chinese Center For Disease Control and Prevention
2023-2024
China Medical University
2019-2024
Hospital of Hebei Province
2022-2024
China Three Gorges University
2021-2023
Yichang Central People's Hospital
2023
First Hospital of China Medical University
2020
Nanjing Medical University
2017-2018
MYCN amplification drives the development of neuronal cancers in children and adults. Given challenge therapeutically targeting directly, we searched for MYCN-activated metabolic pathways as potential drug targets. Here report that neuroblastoma cells with show increased transcriptional activation serine-glycine-one-carbon (SGOC) biosynthetic pathway an dependence on this supplying glucose-derived carbon serine glycine synthesis. Small molecule inhibitors block exhibit selective cytotoxicity...
AMP-activated protein kinase (AMPK) is an evolutionary conserved energy-sensing enzyme that regulates cell metabolism. Emerging evidence indicates AMPK also plays important role in modulating endothelial function. In the present study, we investigated whether modulates growth. Treatment of cultured human umbilical vein cells with activators 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR),...
Lactate dehydrogenase C is an isoenzyme of lactate and a member the cancer–testis antigens family. In this study, we aimed to investigate expression functional role its basic mechanisms in renal cell carcinoma. First, total 133 cases carcinoma samples were analysed tissue microarray, Kaplan–Meier survival curve analyses performed correlation between progression. protein levels messenger RNA significantly upregulated tissues, patients with positive had shorter progression-free survival,...
Abstract High-risk neuroblastoma exhibits transcriptional activation of the mevalonate pathway that produces cholesterol and nonsterol isoprenoids. A better understanding how this metabolic reprogramming contributes to development could help identify potential prevention treatment strategies. Here, we report both geranylgeranyl-pyrophosphate branches are critical sustain cell growth. Blocking by simvastatin, a cholesterol-lowering drug, impeded growth in line xenograft, patient-derived...
6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl]-3-pyridin-4-yl-pyrazolo[1,5-<i>a</i>] pyrimidine (compound C) is a cell-permeable pyrrazolopyrimidine derivative that acts as potent inhibitor of AMP-activated protein kinase (AMPK). Although compound C often used to determine the role AMPK in various physiological processes, it also evokes AMPK-independent actions. In present study, we investigated whether influences vascular smooth muscle cell (SMC) function through pathway. Treatment rat aortic SMCs...
Abstract Metabolic reprogramming is an integral part of the growth-promoting program driven by MYC family oncogenes. However, this also imposes metabolic dependencies that could be exploited therapeutically. Here we report pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) attractive therapeutic target for MYCN -amplified neuroblastoma, a childhood cancer with poor prognosis. Gene expression profiling and metabolomic analysis reveal promotes nucleotide production...
Psoriasis is a chronic inflammatory skin disease characterized by well‑defined scaly papules and plaques. Interleukin (IL)‑17 involved in its pathogenesis promotes the proliferation of epidermal keratinocytes through signal transducer activator transcription 3 (STAT3) activation. Shikonin, natural naphthoquinone isolated from Lithospermum erythrorhizon, possesses anti‑inflammatory immunosuppressive properties can suppress IL‑17‑induced vascular endothelial growth factor expression inhibiting...
(1) Background: To explore the influencing factors of human papillomavirus (HPV) vaccination among mothers and daughters so as to provide evidence strategies for improving HPV rate 9-18-years-old girls. (2) A questionnaire survey was conducted 9-18-year-old girls from June August 2022. The participants were divided into mother daughter vaccinated group (M1D1), mother-only (M1D0), unvaccinated (M0D0). Univariate tests, logistic regression model, Health Belief Model (HBM) employed factors. (3)...
// Yajie Yu 1, * , Chao Liang Shangqian Wang Jundong Zhu 1 Chenkui Miao Yibo Hua Meiling Bao 2 Qiang Cao Qin Pengfei Shao and Zengjun Department of Urology, The First Affiliated Hospital Nanjing Medical University, 210029, China Pathology, These authors have contributed equally to this work Correspondence to: Shao, email: spf_urology@sina.com Cao, qiang_cao@126.com Keywords: CD151; epithelial-to-mesenchymal transition; metastasis; renal cell carcinoma; TGF-β1/Smad Received: July 17, 2017...
Using a numerical simulation method based on physical equations to obtain the debris flow risk range is important for local-scale assessment. While many models have been used reproduce processes after occurrence, their predictability in potentially catastrophic scenarios has mostly not evaluated detail. Two single-phase and two two-phase were Wayao event 2013. Then 2020 was predicted by four with same parameters The depth distributions of source deposition fan mapped visual interpretation,...
To evaluate the preference of primary HCWs and residents on vaccination consultation in community health services to provide evidence for vaccine hesitancy intervention strategies.
<p>Go analysis of genes up-regulated by simvastatin</p>
<p>GO analysis of genes up-regulated in the Simvastatin plus mevalonate group vs. simvastatin group.</p>
<p>GO analysis of genes down-regulated by simvastatin</p>
<p>Supplementary Figures S1-S7</p>