A5101757074- Stress Responses and Cortisol
- Invertebrate Immune Response Mechanisms
- Aquaculture disease management and microbiota
- Tryptophan and brain disorders
- Neuroendocrine regulation and behavior
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Bipolar Disorder and Treatment
- Genetic Mapping and Diversity in Plants and Animals
- Mental Health Research Topics
- Receptor Mechanisms and Signaling
- Aquaculture Nutrition and Growth
- Anesthesia and Neurotoxicity Research
- Treatment of Major Depression
- Neurobiology and Insect Physiology Research
- Adipose Tissue and Metabolism
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Mosquito-borne diseases and control
- Parasite Biology and Host Interactions
- Neurogenesis and neuroplasticity mechanisms
- Schizophrenia research and treatment
- Physiological and biochemical adaptations
- Crustacean biology and ecology
- Neural dynamics and brain function
Peking University
2016-2025
Peking University Sixth Hospital
2016-2025
Qingdao National Laboratory for Marine Science and Technology
2019-2024
Zhejiang University
2024
Minzu University of China
2023-2024
Capital University
2024
Capital Medical University
2024
Chinese Academy of Fishery Sciences
2013-2024
Tsinghua University
2024
Laoshan Laboratory
2023
ABSTRACT Adult individuals with early stressful experience exhibit impaired hippocampal neuronal morphology, synaptic plasticity and cognitive performance. While our knowledge on the persistent effects of early‐life stress structure function underlying mechanisms has advanced over recent years, molecular basis immediate postnatal development remains to be investigated. Here, we reported that repeated blockade corticotropin‐releasing hormone receptor 1 (CRHR1) ameliorated stress‐induced...
Calbindin modulates intracellular Ca2+ dynamics and synaptic plasticity. Reduction of hippocampal calbindin levels has been implicated in early-life stress-related cognitive disorders, but it remains unclear how distinct populations neurons contributes to stress-induced memory loss. Here we report that stress suppressed CA1 dentate gyrus (DG) neurons, knockdown adult or DG excitatory mimicked In contrast, interneurons preserved long-term even after an acute challenge. These results indicate...
Cognitive dysfunction is a significant, untreated clinical need in patients with psychiatric disorders, for which preclinical studies are needed to understand the underlying mechanisms and identify potential therapeutic targets. Early-life stress (ELS) leads long-lasting deficits of hippocampus-dependent learning memory adult mice, may be associated hypofunction brain-derived neurotrophic factor (BDNF) its high-affinity receptor, tropomyosin receptor kinase B (TrkB). In this study, we...
Previous neuroimaging studies have revealed abnormal functional connectivity of brain networks in patients with major depressive disorder (MDD), but findings been inconsistent. A recent big-data study found intrinsic within the default mode network recurrent MDD not first-episode drug-naïve MDD. This also provided evidence for reduced medicated patients, raising question whether previously observed abnormalities may be attributable to antidepressant effects. The present (ClinicalTrials.gov...
Abstract Background The emotion regulation network (ERN) in the brain provides a framework for understanding neuropathology of affective disorders. Although previous neuroimaging studies have investigated neurobiological correlates ERN major depressive disorder (MDD), whether patients with MDD exhibit abnormal functional connectivity (FC) patterns and FC can serve as therapeutic response signature remain unclear. Methods A large magnetic resonance imaging dataset comprising 709 725 healthy...
Abstract Background Early-life stress (ELS) can cause persistent and irreversible damage to the development, plasticity, cognitive function of hippocampus, leading depression other mental illnesses. However, mechanism negative effects induced by ELS remained unclear. Aims & Objectives Calbindin (CB) is one molecular markers superficial pyramidal neurons (PNs) hippocampal CA1 area. Previous research found that calbindin-positive (CB+) PNs calbindin-negative (CB-) in dorsal (dCA1) region...
Abstract Background Cognitive decline is one of the core symptoms a variety mental diseases. How to improve cognitive function key issues in psychiatric research.Stress, especially early-life stress, increases prevalence diseases adult, and often accompanied by hippocampal- related dysfunctions. However, its pathological mechanism remains unclear. Abnormal functioning Brain-derived neurotrophic factor (BDNF) signaling pathway may be mechanisms. Although abnormal BDNF-TrkB system have been...
Abstract Background Aripiprazole has become one of the most commonly prescribed antipsychotics, including in pregnant women due to a broad range indications psychiatric disorders and relatively fewer metabolic side effects (1-2). Compared with other data regarding safety gestational aripiprazole exposure on offspring neurodevelopment is (3). Aims & Objectives This study investigates how prenatal affects hippocampal neuroplasticity adult mice if any such effect can be reversed by...
Abstract Background Accumulating evidences suggest that trace amine-associated receptor 1 (TAAR1) is a new promising target for psychiatric disorders since TAAR1 was discovered in 2001[1, 2]. Stressful life events are key environmental risk factor to develop major depressive disorder (MDD) [3]. Studies humans and animals have demonstrated depression stress induced pathologies implicated the dentate gyrus (DG), one of regions HPA axis glucocorticoid feedback [4]. exhibits widespread...
Abstract Background Striatum is a key node in reward circuit and aberrant striatal functional connectivity (FC) underlies the pathophysiology of bipolar disorder (BD) (Dandash et al., 2018, Karcher 2019) (Teng 2013) (Altinay 2016). However, it unknown how FC abnormalities are related to itself (trait effects) or manic/hypomanic depressive states (state effects), whether dimensional striatum would be critical mechanism underlying symptomatology BD across mood states, particularly both...
Abstract Background Witnessing traumatic events is a common adverse life experience in children or adolescents and associated with several effects. The role of hippocampus adolescent witnessing stress needs to be uncovered. Aims & Objectives To establish the CWSD model male mice reveal involvement CWSD-induced cognitive emotional problems. Method Cognitive anxiety-like behaviors were assessed exposed chronic social defeat (CWSD) stress. Immediate early gene c-fos immunostaining was used...
Summary Objective Growing evidence has implicated dysfunction of the thalamus and its projection cortical targets in depression. However, anatomical specificity thalamo‐cortical connectivity major depressive disorder ( MDD ) remains unknown due to regional heterogeneity limited methods examine this. Methods Resting‐state fMRI was collected on 70 patients healthy controls. The parcellated based with six predefined regions interest ROI s). segmented thalamic nuclei were used as seeds map rest...
Carbonate alkalinity, salinity, and pH are three important stress factors for aquatic animals in saline–alkaline water. Carbonic anhydrases (CAs) catalyze the reversible reaction of CO2 reported to play an role acid–base regulation vertebrates. To explore molecular mechanism CAs efficacy shrimp after their transfer into water, cDNAs (EcCAc, EcCAg, EcCAb) were cloned from Exopalaemon carinicauda. Sequence analysis showed that EcCAc EcCAg both possessed a conserved α-CA domain proton acceptor...
Background: The overall satisfaction of patients after total knee arthroplasty (TKA) is approximately 80%, and current studies have demonstrated that with depression may lower patient satisfaction. purpose this study was to determine whether perioperative psychological intervention in improves the clinical outcomes undergoing TKA. Methods: Six hundred who underwent primary TKA from May 2016 January 2018 were prospectively screened for eligibility. A preoperative evaluation conducted by a...