A5100455777- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Mental Health Research Topics
- Stress Responses and Cortisol
- 14-3-3 protein interactions
- Photoreceptor and optogenetics research
- Genetic Associations and Epidemiology
- Neurotransmitter Receptor Influence on Behavior
- Treatment of Major Depression
- Neural and Behavioral Psychology Studies
- Circadian rhythm and melatonin
- Advanced Neuroimaging Techniques and Applications
- Regulation of Appetite and Obesity
- Nerve injury and regeneration
China Medical University
2018-2025
Zhongda Hospital Southeast University
2023
First Hospital of China Medical University
2018-2022
Abstract Background The emotion regulation network (ERN) in the brain provides a framework for understanding neuropathology of affective disorders. Although previous neuroimaging studies have investigated neurobiological correlates ERN major depressive disorder (MDD), whether patients with MDD exhibit abnormal functional connectivity (FC) patterns and FC can serve as therapeutic response signature remain unclear. Methods A large magnetic resonance imaging dataset comprising 709 725 healthy...
Accumulating evidence showed that major depressive disorder (MDD) is characterized by a dysfunction of serotonin neurotransmission. Raphe nuclei are the sources most serotonergic neurons project throughout brain. Incorporating measurements activity within raphe into analysis connectivity characteristics may contribute to understanding how neurotransmitter synthesized centers involved in pathogenesis MDD. Here, we analyzed resting-state functional magnetic resonance imaging (RS-fMRI) dataset...
Based on genome-wide association studies, a single-nucleotide polymorphism in the NRGN gene (rs12807809) is considered associated with schizophrenia (SZ). Moreover, hippocampal dysfunction rs12807809. In addition, converging evidence suggests that involved SZ pathophysiology. However, among rs12807809, and pathophysiology unknown. Therefore, this study investigated between rs12807809 functional connectivity at rest SZ. total, 158 participants were studied, including C-carrier group carrying...
Dimensional psychopathology and its neurobiological underpinnings could provide important insights into major psychiatric disorders, including depressive disorder, bipolar disorder schizophrenia. In a dimensional transdiagnostic approach, we examined symptoms their relationships with regional homogeneity leptin across disorders. A total of 728 participants (including 403 patients disorders 325 age-gender-matched healthy controls) underwent resting-state functional magnetic resonance imaging...
The fundamental mechanism underlying emotional processing in major depressive disorder (MDD) remains unclear. To better understand the neural correlates of MDD, we investigated role multiple functional networks (FNs) during stimuli processing. Thirty-two medication-naïve subjects with MDD and 36 healthy controls (HCs) underwent an faces fMRI task that included neutral, happy fearful expressions. Spatial independent component analysis (sICA) general linear model (GLM) were conducted to...
Background Leptin is a multifunctional hormone secreted from adipose tissue, which plays core role in regulating energy intake and expenditure. Evidence has demonstrated that leptin receptors are located brain areas involved emotional processing, major depressive disorder (MDD) characterized by dysfunction of processing. Taken together, these features suggest may play potential the pathophysiology MDD. However, precise roles modulating symptoms MDD remain unclear. Methods Participants [18...
Objective To investigate gender differences of plasma glial cell line-derived neurotrophic factor (GDNF) levels in patients with major depressive disorder (MDD). Methods MDD subjects (male 20, female 36) and healthy controls (HCs) 35, 45) were divided into four groups by gender. Plasma GDNF measured compared different groups. The clinical symptom severity MDD was evaluated 17-item Hamilton Depression Scale (HAMD-17) Anxiety (HAMA-17). Results (1)The level male...