A5070376724- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Mental Health Research Topics
- Dementia and Cognitive Impairment Research
- Memory and Neural Mechanisms
- Neural and Behavioral Psychology Studies
- Alzheimer's disease research and treatments
- Fetal and Pediatric Neurological Disorders
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Vestibular and auditory disorders
- Neurological Disease Mechanisms and Treatments
- Autism Spectrum Disorder Research
- Neurobiology of Language and Bilingualism
- Long-Term Effects of COVID-19
- Heart Rate Variability and Autonomic Control
- Schizophrenia research and treatment
- MRI in cancer diagnosis
- Migraine and Headache Studies
- Moyamoya disease diagnosis and treatment
- Epilepsy research and treatment
- Nerve injury and regeneration
- Health, Environment, Cognitive Aging
East China Normal University
2020-2025
Shanghai Center for Brain Science and Brain-Inspired Technology
2019-2025
New York University Shanghai
2024-2025
Shanghai Changning Mental Health Center
2021-2024
National Yang Ming Chiao Tung University
2012-2021
National Yang Ming University Hospital
2011-2021
Fudan University
2019-2020
Shanghai Institute for Science of Science
2019-2020
Following a first version AAL of the automated anatomical labeling atlas (Tzourio-Mazoyer et al., 2002), second (AAL2) (Rolls 2015) was developed that provided an alternative parcellation orbitofrontal cortex following description by Chiavaras, Petrides, and colleagues. We now provide third version, AAL3, which adds number brain areas not previously defined, but interest in many neuroimaging investigations. The 26 new are subdivision anterior cingulate into subgenual, pregenual supracallosal...
BackgroundIncreasing evidence supported the possible neuro-invasion potential of SARS-CoV-2. However, no studies were conducted to explore existence micro-structural changes in central nervous system after infection. We aimed identify brain related SARS-CoV-2.MethodsIn this prospective study, diffusion tensor imaging (DTI) and 3D high-resolution T1WI sequences acquired 60 recovered COVID-19 patients (56.67% male; age: 44.10 ± 16.00) 39 age- sex-matched non-COVID-19 controls (56.41% 45.88...
The first brain-wide voxel-level resting state functional connectivity neuroimaging analysis of depression is reported, with 421 patients major depressive disorder and 488 control subjects. Resting between different voxels reflects correlations activity those a fundamental tool in helping to understand the brain regions altered function depression. One circuit involved medial orbitofrontal cortex Brodmann area 13, which implicated reward, had reduced memory systems parahippocampal gyrus...
The human orbitofrontal cortex, ventromedial prefrontal cortex (vmPFC), and anterior cingulate are involved in reward processing thereby emotion but also implicated episodic memory. To understand these regions better, the effective connectivity between 360 cortical 24 subcortical was measured 172 humans from Human Connectome Project complemented with functional diffusion tractography. has gustatory, olfactory, temporal visual, auditory, pole areas. to pregenual posterior hippocampal system...
Significance Using network analysis of resting-state functional MRI data, we demonstrate that significant randomization global metrics, and greater resilience to targeted attack on hubs, was replicably demonstrable in Chinese patients with schizophrenia, also demonstrated for the first time their nonpsychotic first-degree relatives. These results support hypothesis networks are abnormally randomized resilient schizophrenia indicate randomization/resilience may be an endophenotype, or marker...
Studies of brain functional connectivity have provided a better understanding organization and integration large-scale networks. Functional using resting-state magnetic resonance imaging (fMRI) is typically based upon the correlations low-frequency fluctuation fMRI signals. Reproducible spatial maps in also been observed amplitude fluctuations (ALFF) resting-state. However, little known about influence ALFF on measures. In present study, we analyzed data 79 healthy old individuals. Spatial...
Abstract Bumetanide has been reported to alter synaptic excitation–inhibition (E-I) balance by potentiating the action of γ-aminobutyric acid (GABA), thereby attenuating severity autism spectrum disorder (ASD) in animal models. However, clinical evidence its efficacy young patients with ASD is limited. This was investigated present trial 83 patients, randomised bumetanide group (bumetanide treatment, 0.5 mg twice daily) or control (no treatment). Primary [Children Autism Rating Scale...
To analyze the functioning of posterior cingulate cortex (PCC) in depression, we performed first fully voxel-level resting state functional-connectivity neuroimaging analysis depression PCC, with 336 patients major depressive disorder and 350 controls. Voxels PCC had significantly increased functional connectivity lateral orbitofrontal cortex, a region implicated non-reward which is thereby depression. In receiving medication, between was decreased back towards that controls, it shown has...
Abstract The human hippocampus is involved in forming new memories: damage impairs memory. dual stream model suggests that object “what” representations from ventral temporal cortex project to the via perirhinal and then lateral entorhinal cortex, spatial “where” dorsal parietal parahippocampal gyrus medial cortex. can associate these inputs form episodic memories of what happened where. Diffusion tractography was used reveal direct connections hippocampal system areas humans. This provides...
To advance understanding of brain networks involved in language, the effective connectivity between 26 cortical regions implicated language by a community analysis and 360 was measured 171 humans from Human Connectome Project, complemented with functional diffusion tractography, all using HCP multimodal parcellation atlas. A (semantic) network (Group 1) involving inferior superior temporal sulcus cortex (STS) adjacent visual TE1a pole TG, connected parietal PGi region, has (TE) regions; PFm...
The human posterior cingulate, retrosplenial, and medial parietal cortex are involved in memory navigation. functional anatomy underlying these cognitive functions was investigated by measuring the effective connectivity of Posterior Cingulate Division (PCD) regions Human Connectome Project-MMP1 atlas 171 HCP participants, complemented with diffusion tractography. First, postero-ventral parts PCD (31pd, 31pv, 7m, d23ab, v23ab) have temporal pole, inferior visual cortex, superior sulcus...
Abstract The effective connectivity between 21 regions in the human posterior parietal cortex, and 360 cortical was measured 171 Human Connectome Project (HCP) participants using HCP atlas, complemented with functional diffusion tractography. Intraparietal areas LIP, VIP, MIP, AIP have from early visual regions, to visuomotor such as frontal eye fields, consistent functions saccades tracking. Five superior area 7 receive similar intraparietal areas, but also somatosensory inputs connect...
The effective connectivity between 55 visual cortical regions and 360 was measured in 171 HCP participants using the HCP-MMP atlas, complemented with functional diffusion tractography. A Ventrolateral Visual "What" Stream for object face recognition projects hierarchically to inferior temporal cortex, which orbitofrontal cortex reward value emotion, hippocampal memory system. Ventromedial "Where" scene representations connects parahippocampal gyrus hippocampus. An Inferior STS (superior...
Abstract Effective connectivity, functional and tractography were measured between 57 cortical frontal somatosensory regions the 360 in Human Connectome Project (HCP) multimodal parcellation atlas for 171 HCP participants. A ventral stream connects from 3b 3a via 1 2 then opercular to insula, which inferior parietal PF regions. This is implicated “what”-related processing of objects body combining with visual inputs PF. dorsal “action” area 5 7. Inferior prefrontal have connectivity temporal...
The lifespan growth of the functional connectome remains unknown. Here, we assemble task-free and structural magnetic resonance imaging data from 33,250 individuals aged 32 postmenstrual weeks to 80 years 132 global sites. We report critical inflection points in nonlinear curves mean variance connectome, peaking late fourth third decades life, respectively. After constructing a fine-grained, lifespan-wide suite system-level brain atlases, show distinct maturation timelines for segregation...
Various indicators of neurodegeneration (N) are used in the assessment neuronal injury Alzheimer's disease (AD). The heterogeneity such is less clear. A total 416 individuals with different cognitive statuses were recruited for this study. Differential associations hippocampal volume (HV), 18F-fluorodeoxyglucose positron emission tomography (FDG PET) standardized uptake value ratios (SUVRs), and plasma neurofilament light chain (NfL) levels amyloid beta (Aβ)-tau pathology impairment...
Previous functional imaging studies in episodic cluster headache (CH) patients revealed altered brain metabolism concentrated on the central descending pain control system. However, it remains unclear whether changes during "in bout" period are due to structural and these vary between "out of periods. To quantify CH patients, regional gray matter volume (GMV) was compared among 49 age- sex-matched controls. Twelve were rescanned evaluate changes, if any, 2 Compared with healthy controls,...
Abstract Schizophrenia is characterized by heterogeneous pathophysiology. Using multiscale entropy (MSE) analysis, which enables capturing complex dynamics of time series, we MSE patterns blood‐oxygen‐level‐dependent (BOLD) signals across different scales and determined whether BOLD activity in patients with schizophrenia exhibits increased complexity (increased all scales), decreased toward regularity (decreased or uncorrelated randomness (high short followed decayed as the scale...
To analyse the functioning of amygdala in depression, we performed first voxel-level resting state functional-connectivity neuroimaging analysis depression voxels with all other brain, 336 patients major depressive disorder and 350 controls. Amygdala had decreased functional connectivity (FC) orbitofrontal cortex, temporal lobe areas, including pole, inferior gyrus parahippocampal gyrus. The reductions strengths FC medial cortex were correlated increases Beck Depression Inventory score...