A5103138890- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Transcranial Magnetic Stimulation Studies
- Neuroscience and Music Perception
- Epilepsy research and treatment
- Migraine and Headache Studies
- Hearing Loss and Rehabilitation
- Trigeminal Neuralgia and Treatments
- Neurological disorders and treatments
- Vestibular and auditory disorders
- Pharmacological Effects and Toxicity Studies
- Multisensory perception and integration
- Neuroscience and Neuropharmacology Research
- Motor Control and Adaptation
- Muscle activation and electromyography studies
- Neural and Behavioral Psychology Studies
- Pain Mechanisms and Treatments
- Acute Ischemic Stroke Management
- Neuroscience and Neural Engineering
- Advanced MRI Techniques and Applications
- Neurobiology of Language and Bilingualism
- Visual perception and processing mechanisms
- Stroke Rehabilitation and Recovery
- Neurogenesis and neuroplasticity mechanisms
Nagoya University
2025
Taipei Veterans General Hospital
2014-2023
National Yang Ming Chiao Tung University
2014-2023
National Synchrotron Radiation Research Center
2022-2023
National Yang Ming University Hospital
2011-2020
Taipei Medical University
2007-2016
Buddhist Tzu Chi General Hospital
2015
National Taipei University
2002-2014
Taipei Institute of Pathology
2005-2014
Chang Gung University
2013
Persistent aura without infarction, a rare migraine disorder, is defined by symptoms that persist for >1 week radiological evidence of cerebral infarction. To unveil its pathophysiological mechanisms, this study used magnetoencephalography to characterize the visual cortex excitability in persistent comparison with episodic and chronic migraine. We recruited six patients aura, 39 [12 ictal phase; 27 interictal phase (with n = 9; 18)], 18 24 healthy controls. Five sequential blocks 50...
Previous functional imaging studies in episodic cluster headache (CH) patients revealed altered brain metabolism concentrated on the central descending pain control system. However, it remains unclear whether changes during "in bout" period are due to structural and these vary between "out of periods. To quantify CH patients, regional gray matter volume (GMV) was compared among 49 age- sex-matched controls. Twelve were rescanned evaluate changes, if any, 2 Compared with healthy controls,...
Episodic migraine (EM) may evolve into the more disabling chronic (CM, monthly days ≥ 8 and headache 15) with unknown mechanism. Aiming to elucidate pathophysiology of CM its relationship EM, this study characterized visual cortical responses in EM. Neuromagnetic visual-evoked left-hemifield checkerboard reversals were obtained patients EM (interictal or ictal states), (interictal) age-matched controls. For each subject, 1500 evoked sequentially divided 30 blocks percentage changes P100m...
Some researchers have suggested that the default mode network (DMN) plays an important role in pathological mechanisms of Alzheimer's disease (AD). To examine whether cortical activities DMN regions show significant difference between mild AD from cognitive impairment (MCI), electrophysiological responses were analyzed 21 (AD) and (MCI) patients during eyes closed, resting-state condition. The spectral power functional connectivity estimated using a minimum norm estimate (MNE) combined with...
Objectives To investigate the structural changes of hippocampus and amygdala their relationships with migraine frequency prognosis. Methods Hippocampus volumes were measured by 3-T brain magnetic resonance imaging (MRI) in 31 controls 122 patients who categorized into eight groups headache frequency: group 1 (1-2 days/month), 2 (3-4), 3 (5-7), 4 (8-10), 5 (11-14), 6 (15-19), 7 (20-24), 8 (25-30). Headache was reassessed years later a reduction ≥50% regarded good outcome. Results fluctuated...
Objectives Variant cytochrome P450 (CYP) 3A4 alleles cannot explain human variation in CYP3A4 expression. This study investigated whether common single-nucleotide polymorphisms (SNPs) multidrug resistance 1 (MDR1), encoding P-glycoprotein, or the pregnane X receptor (PXR) were associated with basal inducible Methods MDR1 G2677T and C3435T SNPs a PXR 6–base pair (bp) deletion genotyped deoxyribonucleic acid from 144 livers 3 cohorts each phenotyped for rifampin (INN, rifampicin)–inducible...
<h3>Background</h3> Neuroimaging studies implicate hypothalamic dysfunction in the pathogenesis of cluster headache (CH). Disruptions non-traditional pain processing areas, including cerebellum and visual cortex, have also been reported CH. It is unknown whether hypothalamus interacts significantly with these any such interactions vary between 'in-bout' 'out-of-bout' periods This study aimed to investigate resting-state functional connectivity (FC) patients <h3>Methods</h3> Using 3-T MRI, we...
Fibromyalgia (FM) is a disabling chronic pain syndrome with unknown pathophysiology. Functional magnetic resonance imaging studies on FM have suggested altered brain connectivity between the insula and default mode network (DMN). However, this change has not been characterized through direct neural signals for exploring embedded spectrotemporal features pertinent clinical relevance.We recorded resting-state magnetoencephalographic activities of 28 patients age- sex-matched controls, analyzed...
Male predominance in active tuberculosis (TB) is widely-reported globally. Gender inequalities socio-cultural status are frequently regarded as contributing factors for disparities sex TB. The of the prevalence latent TB infection (LTBI) less investigated and deserve clarification. In this cross-sectional study conducted a endemic area, we enrolled patients at high-risk LTBI progression from to 2011 2012. Diagnosis was made by QuantiFERON-TB Gold In-Tube (QFT-GIT). Differences terms clinical...
Objective: Previous magnetoencephalographic (MEG) studies showed different P100m (where ‘m’ denotes the magnetic counterpart of P100 in conventional visual evoked potentials) responses between episodic migraine (EM) and chronic (CM) interictally. This study investigated changes CM patients who remitted to EM from after treatment. Methods: At baseline, 25 with were studied For each patient, 30 sequential blocks 50 obtained by MEG. Sub-averaged amplitudes at 2, 9, 16, 23 further compared that...
This study aimed to explore the effects of theory mind (ToM) and related potential risk factors, including cognitive functions, psychiatric status, seizure-related clinical variables, on social functioning in patients with temporal lobe epilepsy (TLE).Sixty-seven intractable TLE who were candidates for surgery 30 matched controls included. All participants completed four tasks measuring different levels ToM (False Belief, Faux Pas Recognition, Implication Stories, Visual Cartoon), Symptom...
Background The role of central pulsatile hemodynamics in the pathogenesis white matter hyperintensities migraine patients has not been clarified. Methods Sixty with (20-50 years old; women, 68%) without overt vascular risk factors and 30 demographically-matched healthy controls were recruited prospectively. Cerebral volume was determined by T1-weighted magnetic resonance imaging CUBE-fluid-attenuated-inversion-recovery sequences. Central systolic blood pressure, carotid-femoral pulse wave...
Poststroke sudden sensorineural hearing loss (SSNHL) can hinder communication between patients and healthcare professionals, thereby restricting participation in rehabilitation programs limiting improvements physical performance. However, the relationship stroke SSNHL remains unclear. This study employed a nationwide population-based dataset to investigate SSNHL. The Taiwan Longitudinal Health Insurance Database was used compile data from 11,115 comparison cohort of 33,345 matched nonstroke...