A5100687627- Functional Brain Connectivity Studies
- Retinal Diseases and Treatments
- Advanced Neuroimaging Techniques and Applications
- Ovarian function and disorders
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Nicotinic Acetylcholine Receptors Study
- RNA modifications and cancer
- Ion Transport and Channel Regulation
- Cancer-related molecular mechanisms research
- Smoking Behavior and Cessation
- Plant Pathogens and Fungal Diseases
- Glaucoma and retinal disorders
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Retinal Development and Disorders
- Retinal and Optic Conditions
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Plant and Fungal Species Descriptions
- Plant Stress Responses and Tolerance
- Phytochemistry and biological activities of Ficus species
- Plant responses to water stress
- Advanced biosensing and bioanalysis techniques
- Reproductive System and Pregnancy
- Neonatal Respiratory Health Research
Shanghai Chest Hospital
2024-2025
ShanghaiTech University
2023-2025
Shanghai Jiao Tong University
2024-2025
Center for Excellence in Molecular Cell Science
2021-2024
University of Chinese Academy of Sciences
2021-2024
Sixth Affiliated Hospital of Kunming Medical University
2023-2024
Kunming Medical University
2023-2024
Shandong Provincial Hospital
2021-2024
Shandong University
2021-2024
Dali University
2023
Abstract Background Non-small cell lung cancer (NSCLC) cells derived intracellular and extracellular programmed death ligand 1 (PD-L1) promoted progression drug resistance, facilitated tumor immune evasion. However, the detailed molecular mechanisms are still largely unknown. In present study, we aimed to explore role of circular RNA circ-CPA4/let-7 miRNA/PD-L1 axis in regulation NSCLC progression, resistance microenvironment. Methods Real-Time qPCR Western Blot analysis were conducted...
Objective Polycystic ovary syndrome (PCOS) is a frequent reproductive and metabolic disorder associated with insulin resistance (IR). Berberine (BBR) an isoquinoline derivative alkaloid extracted from Chinese medicinal herbs that has been used as sensitizer. BBR may have potential therapeutic value for PCOS. The aim of this study was to evaluate the effects in comparison metformin (MET) on features women Design methods Eighty-nine subjects PCOS IR were randomized into one three treatment...
Although serine metabolism plays a crucial role in the proliferation and survival of tumor cells, how it supports cell migration remains poorly understood. Phosphoglycerate dehydrogenase (PHGDH) catalyzes oxidation 3-phosphoglycerate to 3-phosphonooxypyruvate, first committed step de novo biosynthesis. Here we show that PHGDH was monoubiquitinated by cullin 4A-based E3 ligase complex at lysine 146 colorectal cancer (CRC) which enhanced activity recruiting chaperone protein, DnaJ homolog...
Summary Objective Previous studies have indicated that berberine is an effective insulin sensitizer with comparable activity to metformin ( Diabetes 2006, 55, 2256). Reduced sensitivity reportedly a factor adversely affecting the outcome of IVF in patients polycystic ovary syndrome (PCOS) Human Reproduction 21, 1416). Our objective was evaluate clinical, metabolic and endocrine effects vs PCOS women scheduled for treatment explore potential benefits process. Design We performed prospective...
Although the activation of prefrontal cortex (PFC) and striatum had been found in smoking cue induced craving task, whether how functional interactions white matter integrity between these brain regions contribute to processing during exposure remains unknown. Twenty-five young male smokers 26 age- gender-matched nonsmokers participated cue-reactivity task. Craving related was extracted psychophysiological (PPI) analysis used specify PFC-efferent pathways contributed cue-induced craving....
Abstract Schizophrenia is characterized by dysconnectivity syndrome. Evidence of widespread impairment structural and functional integration has been demonstrated in schizophrenia. Although white matter (WM) microstructural abnormalities have commonly reported schizophrenia, the dysfunction WM as well relationship between structure function remains uncertain. In this study, we proposed a novel structure-function coupling measurement to reflect neuronal information transfer, which combined...
Loss of Protocadherin 9 (PCDH9) is associated with the metastasis and prognosis gastric cancer patients, while molecular mechanism PCDH9-impaired remains unclear. Here we show that PCDH9 cleaved in cells. Intracellular domain translocates into nucleus, where it interacts DNA methyltransferase 1 (DNMT1) increases DNMT1 activity. Activated downregulates cadherin 2 (
Abstract Drug-induced liver injury (DILI) is the leading cause of acute failure and poses a significant clinical challenge in both diagnosis treatment. Serine synthesis pathway (SSP) links glycolysis to one-carbon cycle plays an important role cell homeostasis by regulating substance synthesis, redox gene expression. However, regulatory mechanism SSP DILI remains unclear. Phosphoglycerate dehydrogenase (PHGDH) rate-limiting enzyme SSP. Here we show that during DILI, mitogen-activated protein...
The heterogeneity of cancer-associated fibroblasts (CAFs) has become a crucial focus in understanding cancer biology and treatment response, revealing distinct subpopulations with specific roles tumor pathobiology. CAFs have also been shown to promote resistance lung cells epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). However, the CAF subsets responsible for driving advancement EGFR-TKIs adenocarcinoma (LUAD) remain poorly understood. We integrate multiple...
Neonatal brain development constitutes a critical period of structural and functional maturation underpinning sensory, motor, cognitive capacities. The glymphatic system-a cerebral waste clearance network-remains poorly understood in neonates. We investigated non-invasive magnetic resonance imaging (MRI) biomarkers system their developmental correlates In 117 neonates undergoing high-resolution T1-weighted diffusion MRI, we quantified two metrics: (1) tensor along the perivascular space...
Circular RNAs (circRNAs) act as a crucial part in many human diseases, particularly cancers. circRNA HIPK3 (circHIPK3) is special that may participate the oncogenesis of non-small-cell lung cancer (NSCLC), even though its latent regulatory mechanism not very clear. Here, we studied roles circHIPK3 NSCLC. qRT-PCR assay was applied to study expression The influence on NSCLC estimated by silencing and miR-107 mock transfection brain-derived neurotrophic factor (BDNF) overexpression, correlation...
Circular RNAs (circRNAs) play an important regulatory role in various cancers, including hepatocellular carcinoma (HCC). This study aimed to investigate the function of hsa_circ_0006942 (circ-ATP5H) hepatitis B virus (HBV)-associated HCC and its underlying mechanism.The levels circ-ATP5H, miR-138-5p tumor necrosis factor alpha-induced protein 3 (TNFAIP3) were determined using quantitative real-time polymerase chain reaction (qRT-PCR) or Western blot assay. The copies HBV DNA examined...
Accumulating evidence showed that major depressive disorder (MDD) is characterized by a dysfunction of serotonin neurotransmission. Raphe nuclei are the sources most serotonergic neurons project throughout brain. Incorporating measurements activity within raphe into analysis connectivity characteristics may contribute to understanding how neurotransmitter synthesized centers involved in pathogenesis MDD. Here, we analyzed resting-state functional magnetic resonance imaging (RS-fMRI) dataset...
Abstract Background Endophytic bacteria have been demonstrated to be one of the most potentially important biocontrol agents for their efficiently improved plant growth and protection host plants from infection by phytopathogens. Results Nine strains endophytic isolated Glycyrrhiza uralensis Fisch. ( G. ) seeds were screened inhibitory effect against 5 fungal phytopathogens using dual culture method. Among which, isolate FT 2 showed highest percentage inhibition all test Detached root assay...
Background. It has been suggested in recent studies that matrix metalloproteinases (MMPs) may be implicated the pathogenesis of polycystic ovary syndrome (PCOS) through regulating ovarian tissue remodeling. In addition to degrading extracellular matrix, MMPs exhibit ability cleave insulin-like growth factor binding protein-1 (IGFBP-1), major regulator factor-I (IGF-I) serum. The present study aimed investigate possible role pathophysiology PCOS.Methods. Serum levels MMP-9, inhibitor...