A5044454984- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Cancer-related molecular mechanisms research
- AI in cancer detection
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- FOXO transcription factor regulation
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Wnt/β-catenin signaling in development and cancer
- S100 Proteins and Annexins
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Liver Disease Diagnosis and Treatment
- Metastasis and carcinoma case studies
- MicroRNA in disease regulation
- Hippo pathway signaling and YAP/TAZ
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2017-2024
Shanghai University of Traditional Chinese Medicine
2017-2024
University of California, Irvine
2024
Tongji Hospital
2024
Tongji University
2024
First Affiliated Hospital of Wenzhou Medical University
2020-2023
Wenzhou Medical University
2018-2023
Changhai Hospital
2023
Second Military Medical University
2016-2023
Peking University
1998-2021
Abstract N-staging is a determining factor for prognostic assessment and decision-making stage-based cancer therapeutic strategies. Visual inspection of whole-slides intact lymph nodes currently the main method used by pathologists to calculate number metastatic (MLNs). Moreover, even at same N stage, outcome patients varies dramatically. Here, we propose deep-learning framework analyzing node whole-slide images (WSIs) identify tumor regions, then uncover tumor-area-to-MLN-area ratio...
A key feature of TGF-β signaling activation in cancer cells is the sustained SMAD complexes nucleus; however, drivers are poorly defined. Here, using human and mouse breast cell lines, we found that oncogene forkhead box M1 (FOXM1) interacts with SMAD3 to sustain SMAD3/SMAD4 complex nucleus. FOXM1 prevented E3 ubiquitin-protein ligase transcriptional intermediary factor 1 γ (TIF1γ) from binding monoubiquitinating SMAD4, which stabilized complex. Loss abolished TGF-β-induced formation....
Abstract Purpose: We determined the expression of mammalian target rapamycin (mTOR) and its activated form, p-mTOR, in Chinese patients with gastric cancer clinical effects underlying mechanisms. Experimental Design: Tissue microarray blocks containing tissue matched noncancer specimens obtained from 1,072 were constructed. Expression total mTOR p-mTOR these was analyzed using immunohistochemical studies confirmed by Western blotting. Results: The overall rates overexpression 50.8% (545...
Tumour pathology contains rich information, including tissue structure and cell morphology, that reflects disease progression patient survival. However, phenotypic information is subtle complex, making the discovery of prognostic indicators from pathological images challenging.An interpretable, weakly supervised deep learning framework incorporating prior knowledge was proposed to analyse hepatocellular carcinoma (HCC) explore new phenotypes on whole-slide (WSIs) Zhongshan cohort 1125 HCC...
Lung cancer (LC) is a leading cause of cancer-related deaths worldwide. Its rapid growth requires hyperactive catabolism principal metabolic fuels. It unclear whether fructose, an abundant sugar in current diets, essential for LC. We demonstrated that, under the condition coexistence fuels body, fructose was readily used by LC cells vivo as glucose alternative via upregulating GLUT5, major transporter encoded solute carrier family 2 member 5 (SLC2A5). Metabolomic profiling coupled with...
Although serine metabolism plays a crucial role in the proliferation and survival of tumor cells, how it supports cell migration remains poorly understood. Phosphoglycerate dehydrogenase (PHGDH) catalyzes oxidation 3-phosphoglycerate to 3-phosphonooxypyruvate, first committed step de novo biosynthesis. Here we show that PHGDH was monoubiquitinated by cullin 4A-based E3 ligase complex at lysine 146 colorectal cancer (CRC) which enhanced activity recruiting chaperone protein, DnaJ homolog...
The therapeutic and prognostic value of the glycolytic enzymes hexokinase, phosphofructokinase, pyruvate kinase (PK) has been implicated in a variety cancers, while their roles treatment prognosis for hilar cholangiocarcinoma (HC) remain unclear. In this study, we determined expression PKM2 its impact on biology clinical outcome human HC.The regulation function HC pathogenesis was evaluated using tissues, molecular cell biology, animal models, significance according to patient survival.We...
// Guanzhen Yu 1, 2, * , Wenzheng Fang 7, Tian Xia 3, 6, Ying Chen 4, Yunshu Gao 5 Xiaodong Jiao 1 Suyun Huang 2 Jiejun Wang Zhaosheng Li 3 Keping Xie 6 Department of Medical Oncology, Changzheng Hospital, Shanghai 200070, China Neurosurgery, The University Texas MD Anderson Cancer Center, Houston, 77030, USA Gastroenterology, Changhai 200433, 4 Pathology, Qingdao, Shandong 266000, Hepatology & Nutrition, 7 Fuzhou General Clinical College Fujian University, Fuzhou, 350025, These authors have...
Glycogen metabolism commonly altered in cancer is just beginning to be understood. Phosphoglucomutase 1 (PGM1), the first enzyme glycogenesis that catalyzes reversible conversion between glucose 1-phosphate (G-1-P) and 6-phosphate (G-6-P), participates both breakdown synthesis of glycogen. Here, we show PGM1 down-regulated hepatocellular carcinoma (HCC), which associated with malignancy poor prognosis HCC. Decreased expression obstructed pathway, leads increased flow into glycolysis, thereby...
Abstract Background The putative tumor metastasis suppressor 1(MTSS1) is an actin-binding scaffold protein that has been implicated to play important role in carcinogenesis and cancer metastasis, yet its the development of gastric not well illustrated. In this study, we detected MTSS1 expression explored clinical significance cancer. Methods Immunohistochemistry was performed using tissue microarrays containing adenocarcinoma specimens from 1,072 Chinese patients with normal adjacent mucosa,...
SNAT1 is a subtype of the amino acid transport system A that has been implicated to play potential role in cancer development and progression, yet its breast remains unclear. In present study, we detected expression cancers explored underlying mechanism promoting carcinogenesis.RT-PCR Western blotting were performed analyze transcription protein levels cell lines fresh tissues. Tissue microarray blocks containing specimens obtained from 210 patients constructed. Expression these was analyzed...
// Guanzhen Yu 1,3,* , Aidong Zhou 1,* Jianfei Xue 1 Chen Huang 2 Xia Zhang 3 Shin-Hyuk Kang Wen-Tai Chiu Christina Tan Keping Xie 2,4 Jiejun Wang and Suyun 1,4 Departments of Neurosurgery, The University Texas MD Anderson Cancer Center, Houston, TX, USA Gastroenterology, Hepatology, Nutrition, Department Medical Oncology, Changzheng Hospital, Shanghai, People's Republic China 4 Program in Biology, Graduate School Biomedical Sciences at * These authors contributed equally to this work...
Annexin-1 contributes to the pathological consequence and sequelae of most serious human diseases including cardiovascular disease cancer. Although diverse roles in carcinogenesis have been postulated, its role gastrointestinal cancers still remains controversial. The mRNA protein expression profiles ANXA1 were studied esophageal, gastric, pancreatic, colorectal, liver, bile duct using Real-Time PCR, western blotting, immunohistochemistry. Gain/loss-of-function by pcDNA3.1-ANXA1 ANXA1-shRNA...
Histopathological examination is very important for diseases diagnosis and treatment. With the development of artificial intelligence, more pathological databases have been reported histopathological because database quite crucial validation testing feature extraction, statistical analysis deep learning algorithms. However, most these are either gray images or RGB color tissue sections contain limited information samples which performance current There few publicly available that include...
Recent advances in deep learning have produced encouraging results for biomedical image segmentation; however, outcomes rely heavily on comprehensive annotation. In this paper, we propose a neural network architecture and new algorithm, known as overlapped region forecast, the automatic segmentation of gastric cancer images. To best our knowledge, report first time describes that has been applied to Moreover, reiterative framework achieves superior performance without pretraining or further...
Esophageal squamous cell carcinoma (ESCC) is a major histological subtype of esophageal cancer with inferior prognosis. Here, we conducted comprehensive transcriptomic, proteomic, phosphoproteomic, and metabolomic characterization human, treatment-naive ESCC paired normal adjacent tissues (cohort 1, n = 24) in an effort to identify new molecular vulnerabilities for potential therapeutic targets. Integrative analysis revealed small group genes that were related the active posttranscriptional...
Esophageal squamous cell carcinoma (ESCC) is a deadly malignancy with notable metabolic reprogramming, yet the pivotal feature driving ESCC progression remains elusive. Here, we show that methionine cycle exhibits robust activation in and reversely associated patient survival. cells readily harness exogenous to generate S-adenosyl-methionine (SAM), thus promoting proliferation. Mechanistically, augments METTL3-mediated RNA m
Summary Purpose: Metastasis remains an incurable common complication in patients with gastric cancer. A variety of theories have been proposed to explain the inefficiency metastatic process. To compare protein expression metastasis‐related genes (nm23, KISS1, KAI1 and p53) between primary tumours may be useful illustrating these theories. Methods: Metastasis‐related tissue microarrays (including normal tissues, tumours, nodal metastases liver metastases) were constructed. The nm23, p53 lymph...
// Ying Chen 1,* , Zhanshan Cha 2,* Wenzheng Fang 3,* Baohua Qian 2 Wenlong Yu 4 Wenfeng Li 5 Guanzhen 6,7 and Yong Gao 7 1 Department of Pathology, Changhai Hospital, Shanghai, China Transfusion, 3 Oncology, Fuzhou General Fuzhou, Fujian Province, Surgery, Eastern Hepatobiliary Radiation First Affiliated Hospital Wenzhou Medical College, Wenzhou, Zhejiang, 6 Changzheng East Tongji University School Medicine, * These authors have contributed equally to this work Correspondence to: Yu, email:...
PRR11 is a potential candidate oncogene that has been implicated in the pathogenesis of lung cancer, however role gastric cancer currently unclear. In present study, we investigated by evaluating its expression status samples from cohort 216 patients with cancer. was found to be overexpressed 107 (49.5%) immunohistochemistry tissue microarrays generated using patient samples. Furthermore, overexpression correlate significantly clinicopathologic features such as tumor invasion,...