A5042023245- Ubiquitin and proteasome pathways
- Wood Treatment and Properties
- Natural Fiber Reinforced Composites
- Lignin and Wood Chemistry
- Autophagy in Disease and Therapy
- Flame retardant materials and properties
- Endoplasmic Reticulum Stress and Disease
- Cancer, Hypoxia, and Metabolism
- Cancer-related gene regulation
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Advanced Cellulose Research Studies
- Supramolecular Chemistry and Complexes
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Nanocomposite Films for Food Packaging
- Cancer Genomics and Diagnostics
- Supramolecular Self-Assembly in Materials
- interferon and immune responses
- Genomics and Phylogenetic Studies
- Nanoplatforms for cancer theranostics
- Heat shock proteins research
- Fire dynamics and safety research
- Traditional Chinese Medicine Studies
- Prion Diseases and Protein Misfolding
Zhuhai Institute of Advanced Technology
2025
Chinese PLA General Hospital
2012-2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2019-2024
Shanghai University of Traditional Chinese Medicine
2019-2024
Nanjing Institute of Railway Technology
2022-2024
Kingmed Diagnostics
2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2024
University of Idaho
2020-2023
Nanjing Normal University Taizhou College
2022
Guangdong University of Technology
2020-2022
Preparation and biomedical applications of self-healing hydrogels assembled from hosts cyclodextrins cucurbit[<italic>n</italic>]urils with various guests were reviewed.
Label-free, size-dependent, and high-throughput isolation of rare tumor cells from untreated whole blood is enabled by interfacial viscoelastic microfluidics.
The microfluidic passive control of microparticles largely relies on the hydrodynamic effects carrier media such as Newtonian fluids and viscoelastic fluids. Yet viscoelastic/Newtonian interfacial effect has been scarcely investigated, especially for high-resolution particle separation. Here we report a co-flow (water or PBS) (PEO) size-dependent separation microparticles. condition generates stable interface, giving rise to wall-directed elastic lift forces that compete with center-directed...
Lung cancer (LC) is a leading cause of cancer-related deaths worldwide. Its rapid growth requires hyperactive catabolism principal metabolic fuels. It unclear whether fructose, an abundant sugar in current diets, essential for LC. We demonstrated that, under the condition coexistence fuels body, fructose was readily used by LC cells vivo as glucose alternative via upregulating GLUT5, major transporter encoded solute carrier family 2 member 5 (SLC2A5). Metabolomic profiling coupled with...
It is well known that 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP) usually formed in the Maillard reaction and it contributes to antioxidant properties of intermediates. A series hydroxyl group protected DDMP derivatives were synthesized further understand source activity. Antioxidant abilities evaluated by scavenging 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonate) cationic radical (ABTS˙+), 2,2'-diphenyl-1-picrylhydrazyl (DPPH), galvinoxyl radical, respectively. was found...
The neddylation pathway is overactivated in human cancers. Inhibition of has emerged as an attractive anticancer strategy. mechanisms underlying overactivation cancer remain elusive. MLN4924/Pevonedistat, a first-in-class NEDD8-activating enzyme (NAE, E1) inhibitor, exerts significant anti-tumor effects, but its mutagenic resistance remains unresolved.The expression NEDD8-conjugating UBC12/UBE2M (E2) and NEDD8 were estimated by bioinformatics analysis western blot lung cell lines. malignant...
Silver and its derivatives have been widely explored for their antibacterial properties in the treatment of bacterial infections. However, biological toxicity silver limits further development application. In this study, we designed a facially amphiphilic skeleton incorporating crown ether moieties based on dendrimer D-CA6-CE. The high-density units within structure enable chelation ions, forming skeleton-derived D-CA6-CE/Ag+ complexes. These results indicate that can self-assemble into...
Abstract Background Protein neddylation plays a tumor-promoting role in esophageal cancer. Our previous study demonstrated that inhibition induced the accumulation of ATF4 to promote apoptosis cancer cells. However, it is completely unknown whether could induce autophagy cells and affect expression other members ATF/CREB subfamily, such as ATF3. Methods The relevant proteins NF-κB/Catalase/ATF3 pathway after was determined by immunoblotting analysis downregulated siRNA silencing for...
Abstract Protein Preferentially Expressed Antigen in Melanoma (Prame), a tumor-associated antigen, has been found to frequently overexpress various cancers, which indicates advanced cancer stages and poor clinical prognosis. Moreover, previous reports noted that Prame functions as substrate recognizing receptor protein of Cullin RING E3 ligases (CRLs) mediate potential substrates degradation through Ubiquitin Proteasome System (UPS). However, none the specific identified so far. In this...
AQP3 (aquaporin 3 (Gill blood group)), a member of the AQP family, is an aquaglyceroporin which transports water, glycerol and small solutes across plasma membrane. Beyond its role in fluid transport, plays significant regulating various aspects tumor cell behavior, including proliferation, migration, invasion. Nevertheless, underlying regulatory mechanism tumors remains unclear. Here, for first time, we report that direct target ubiquitination by SCF
An activity-based fluorescent probe with the characteristics of AIE + ESIPT has been reported for differentiating alkaline phosphatase activity in different cell lines.
Senescence leads to permanent cell-cycle arrest and is a potential target for cancer therapy. Andrographolide (AD) diterpene lactone isolated from Traditional Chinese Medicine (TCM) Andrographis paniculate, which has been used as an anti-inflammatory drug in clinical practice with the senescence recalcitrant lung cancer.To determine whether AD can induce human adenocarcinoma vitro vivo elucidate underlying mechanisms.SA-β-Gal staining was detect expression of senescence-associated...
Unfolded protein response (UPR) is an adaptive reaction for cells to reduce endoplasmic reticulum (ER) stress. In many types of cancers, such as lung cancer and pancreatic cancer, may harness ER stress facilitate their survival growth. Prion (PrP) a glycosylated cell surface that has been shown be up-regulated in cells. Since PrP prone misfolding, can result under-glycosylated PrP, which turn activate To assess whether leads the production contribute thus leading apoptosis, we treated...