A5005719054- Crystallization and Solubility Studies
- Renal and related cancers
- X-ray Diffraction in Crystallography
- Organ Donation and Transplantation
- Renal and Vascular Pathologies
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Advanced Fiber Laser Technologies
- RNA modifications and cancer
- Molecular Sensors and Ion Detection
- Photonic and Optical Devices
- Autophagy in Disease and Therapy
- Carbon and Quantum Dots Applications
- Advanced biosensing and bioanalysis techniques
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Catalysis and Oxidation Reactions
- Cancer Genomics and Diagnostics
- Catalytic Processes in Materials Science
- Epigenetics and DNA Methylation
- Porphyrin and Phthalocyanine Chemistry
- Adsorption and biosorption for pollutant removal
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
Peking University
2003-2025
State Key Laboratory of Artificial Microstructure and Mesoscopic Physics
2023-2025
Zhongshan Hospital
2018-2024
Fudan University
2018-2024
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2020-2024
Shanghai University of Traditional Chinese Medicine
2020-2024
The First Affiliated Hospital, Sun Yat-sen University
2018-2024
Sun Yat-sen University
2018-2024
Peking University People's Hospital
2024
Shenyang Jianzhu University
2023
Abstract Background Lung cancer is one of the most common tumors in world, and metastasis major causes tumor-related death lung patients. Tumor-associated macrophages (TAMs) are a component tumor microenvironment (TME) frequently associated with human cancers. However, regulatory mechanisms TAMs remain unclear. Methods Single-cell sequencing analysis normal tissues from public databases 14 patients who underwent surgery at Zhongshan Hospital was performed. In vitro co-culture experiments...
// Xing Jin 1,# , Seok Joong Yun 2,# Pildu Jeong 2 Isaac Yi Kim 3 Wun-Jae 2,* Sunghyouk Park 1,* 1 College of Pharmacy, Natural Product Research Institute, Seoul National University, Sillim-dong, Gwanak-gu, Seoul, 151-724, Korea Department Urology, Medicine and Institute for Tumor Research, Chungbuk 52 Naesudong-ro, Heungdeok-gu, Cheongju, Chungbuk, 361-711, Section Urologic Oncology, The Cancer New Jersey, Robert Wood Johnson Medical School, Brunswick, USA. Correspondence: Kim, email :...
Infertility is a common complication in diabetic men, mainly due to the loss of germ cells by apoptotic cell death. However, effective and safe approaches prevent induction testicular apoptosis for patients have not been available. Resveratrol (RSV), group compounds called polyphenols from plants, has indicated its promising used clinically cancers cardiovascular diseases. Therefore, present study aimed determining whether RSV attenuates type 1 diabetes (T1D)-induced death mouse model. We...
Lung cancer (LC) is a leading cause of cancer-related deaths worldwide. Its rapid growth requires hyperactive catabolism principal metabolic fuels. It unclear whether fructose, an abundant sugar in current diets, essential for LC. We demonstrated that, under the condition coexistence fuels body, fructose was readily used by LC cells vivo as glucose alternative via upregulating GLUT5, major transporter encoded solute carrier family 2 member 5 (SLC2A5). Metabolomic profiling coupled with...
Ecofriendly procedure for silver–silver chloride nanoparticle synthesis with different reaction parameters tested.
Quantum fluctuations disrupt the cyclic motions of dissipative Kerr solitons (DKSs) in nonlinear optical microresonators and consequently cause timing jitter emitted pulse trains. This problem is translated to performance several applications that employ DKSs as compact frequency comb sources. Recently, device manufacturing noise reduction technologies have advanced unveil quantum properties DKSs. Here we investigate decoherence existing normal-dispersion known dark pulses. By virtue very...
Electrostrictive Brillouin scattering provides a ubiquitous mechanism to optically excite high-frequency (<a:math xmlns:a="http://www.w3.org/1998/Math/MathML" display="inline"><a:mo form="prefix">></a:mo><a:mn>10</a:mn><a:mtext> </a:mtext><a:mtext> </a:mtext><a:mi>GHz</a:mi></a:math>), bulk acoustic phonons that are robust surface-induced losses. Resonantly enhancing such photon-phonon interactions in high-<d:math xmlns:d="http://www.w3.org/1998/Math/MathML"...
Esophageal squamous cell carcinoma (ESCC) is a deadly malignancy with notable metabolic reprogramming, yet the pivotal feature driving ESCC progression remains elusive. Here, we show that methionine cycle exhibits robust activation in and reversely associated patient survival. cells readily harness exogenous to generate S-adenosyl-methionine (SAM), thus promoting proliferation. Mechanistically, augments METTL3-mediated RNA m
Advancements in metal nanoparticle synthesis using plant extracts and their anticancer activity have received significant attention recent years. The green approach for the of gold nanoparticles (AuNPs) leaf extract Sasa borealis is reported this study. Synthesis AuNPs was performed at 50 °C, formation observed after 20 min incubation. confirmed by UV-visible spectrum peak 542 nm. synthesized were oval, spherical with sizes around 10-30 nm transmission electron microscope. Energy dispersive...
Esophageal squamous cell carcinoma (ESCC) is a major histological subtype of esophageal cancer with inferior prognosis. Here, we conducted comprehensive transcriptomic, proteomic, phosphoproteomic, and metabolomic characterization human, treatment-naive ESCC paired normal adjacent tissues (cohort 1, n = 24) in an effort to identify new molecular vulnerabilities for potential therapeutic targets. Integrative analysis revealed small group genes that were related the active posttranscriptional...
Abstract Acute lymphoblastic leukemia (ALL) is one of the deadly forms childhood cancers in world. In present study, we used both vitro and vivo models to evaluate functional mechanisms a long noncoding RNA (lncRNA), small nucleolar host gene 16 (SNHG16) ALL. SNHG16 expression was evaluated by quantitative real‐time PCR (qPCR) ALL cell lines human samples T lymphocytes. Lentivirus‐mediated downregulation performed MOLT3 SUP‐B15 cells, its effects on proliferation, migration vitro, transplant...
Abstract Background Skeletal muscle as a metabolic consumer determines systemic energy homeostasis by regulating myofibre type conversion and mass control. Perturbation of the skeletal metabolism elevates risk variety diseases including disorders. However, regulatory pathways molecules are not completely understood. The discovery relevant responsible associated network could be an attractive strategy to overcome with problems. Methods An initial screening using quantitative trait locus...
Soliton microcombs generated in nonlinear microresonators facilitate the photonic integration of timing, frequency synthesis, and astronomical calibration functionalities. For these applications, low-repetition-rate soliton are essential as they establish a coherent link between optical microwave signals. However, required pump power typically scales with inverse repetition rate, device footprint square rendering challenging to integrate within circuits. This study designs fabricates silicon...
Kerr microcombs generated in optical microresonators provide broadband light sources bridging and microwave signals. Their translation to thin-film lithium niobate unlocks second-order nonlinear interfaces such as electro-optic modulation frequency doubling for completing comb functionalities. However, the strong Raman response of LiNbO3 has complicated formation microcombs. Until now, dark pulse microcombs, requiring a double balance between nonlinearity normal group velocity dispersion...
Based on the hypothesis that bulky selenium atom, with 4p orbitals, can sterically hinder approach of a cellular kinase to 5'-OH for phosphorylation, 4'-selenonucleosides one-carbon homologation were designed and synthesized via novel seleno-Michael reaction, stereoselectivity controlled by steric effects. 5'-Homo-4'-selenonucleosides (n = 2) demonstrated potent antiherpes simplex virus (HSV-1) activity, indicating atom might play key role in preventing phosphorylation kinases, resulting no...
Abstract Background Protein neddylation plays a tumor-promoting role in esophageal cancer. Our previous study demonstrated that inhibition induced the accumulation of ATF4 to promote apoptosis cancer cells. However, it is completely unknown whether could induce autophagy cells and affect expression other members ATF/CREB subfamily, such as ATF3. Methods The relevant proteins NF-κB/Catalase/ATF3 pathway after was determined by immunoblotting analysis downregulated siRNA silencing for...
Ubiquitin-specific protease 5 (USP5) is a deubiquitinating enzyme that functions as an oncoprotein in variety of human cancers. However, the expression and role USP5 metastasis non-small cell lung cancer (NSCLC) have not been addressed. In this study, we examined prognostic significance NSCLC. The results revealed was overexpressed correlated with overall survival NSCLC tissues. A further vitro study levels protein cells were associated epithelial–mesenchymal transition (EMT) markers....