A5101891316- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cancer Mechanisms and Therapy
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- CAR-T cell therapy research
- RNA Research and Splicing
- Cancer Research and Treatments
- Endoplasmic Reticulum Stress and Disease
- Galectins and Cancer Biology
- Hepatocellular Carcinoma Treatment and Prognosis
- Helicobacter pylori-related gastroenterology studies
- Cancer Immunotherapy and Biomarkers
- Single-cell and spatial transcriptomics
- Lung Cancer Treatments and Mutations
- Phytochemical Studies and Bioactivities
- Autophagy in Disease and Therapy
- Lung Cancer Research Studies
- Healthcare Systems and Reforms
Nantong University
2008-2025
Nantong Tumor Hospital
2008-2025
Heilongjiang Academy of Sciences
2025
Shandong Academy of Sciences
2025
Qilu University of Technology
2025
Chengdu University of Traditional Chinese Medicine
2023-2024
Affiliated Zhongshan Hospital of Dalian University
2020
Zhengzhou University
2010
Health Commission of Jilin Province
2010
University of Chicago
1999
We examined the effect of microRNA-320b (miR-320b) on tumor growth and angiogenesis in lung cancer also determined its downstream molecular mechanisms. Lung tissues adjacent non-cancerous were collected from 66 patients with cancer. miR-320b expression was experimentally to be expressed at low level tissues. The results gain-of-function experiments suggested that overexpression suppressed cell invasion, tube formation, volume xenografted nude mice. Hepatocyte nuclear factor 4 gamma (HNF4G)...
Abstract Hepatocellular carcinoma (HCC) is a heterogeneous tumor with an increased incidence worldwide accompanied by high mortality and dismal prognosis. Emerging evidence indicates that mesenchymal stem cells (MSCs)-derived exosomes possess protective effects against various human diseases transporting microRNAs (miRNAs or miRs). We aimed to explore the role of exosomal miR-15a derived from MSCs its related mechanisms in HCC. Exosomes were isolated transduced co-incubated Hep3B Huh7 cells....
Esophageal squamous cell carcinoma (ESCC) is a major histological subtype of esophageal cancer with inferior prognosis. Here, we conducted comprehensive transcriptomic, proteomic, phosphoproteomic, and metabolomic characterization human, treatment-naive ESCC paired normal adjacent tissues (cohort 1, n = 24) in an effort to identify new molecular vulnerabilities for potential therapeutic targets. Integrative analysis revealed small group genes that were related the active posttranscriptional...
Esophageal squamous cell carcinoma (ESCC) is a deadly malignancy with notable metabolic reprogramming, yet the pivotal feature driving ESCC progression remains elusive. Here, we show that methionine cycle exhibits robust activation in and reversely associated patient survival. cells readily harness exogenous to generate S-adenosyl-methionine (SAM), thus promoting proliferation. Mechanistically, augments METTL3-mediated RNA m
Abstract Background Kidney fibrosis is a crucial component that contributes to end-stage renal disease and the inevitable last pathological process in many progressive chronic kidney diseases (CKD). Ubiquitination, one of most refined widespread reversible post-translational modifications, plays significant role development through its regulation deubiquitination processes. Main body abstract Recent studies have shown ubiquitination represent promising intervention targets against fibrosis,...
Chenopodium album L., as a folkloric herb, is traditionally used to treat poisonous insect bites, vitiligo, and other ailments. However, its impact on thrombosis remains unknown. In this study, we discovered that the ethanol extract of C. exhibited remarkable antithrombotic effect using zebrafish model for first time. Activity evaluation showed fraction CA-C could improve thrombus aggregation in caudal vein, increase blood return heart, alleviate slowing flow compared with those group. Then,...
Background Forkhead Box P1 (FOXP1) has been described as both a tumour suppressor candidate and potential oncogene. The aim of this study is to identify new prognostic biomarkers therapeutic target structures for the diagnosis treatment hepatocellular carcinoma (HCC). Methods expression FOXP1 mRNA in HCC was characterised using real-time PCR 20 pairs fresh frozen tissues corresponding non-cancerous tissues. protein confirmed immunohistochemistry on tissue microarray chip. Finally, correlated...
Aberrations in MYC underlie a large proportion of liver hepatocellular carcinoma (LIHC) cases; however, is difficult to target because its undruggable structure. We aimed uncover MYC-associated molecular targets provide new strategies for LIHC treatment.LIHC transcriptome datasets and clinical information were obtained from The Cancer Genome Atlas. A series bioinformatics analyses performed 370 patients who stratified based on the median expression level (high-MYC group low-MYC group)....
Increasing longevity and advances in treatment have increased the cancer burden elderly, resulting complex follow-up care needs; however, China, little is known about preferences of these patients. This study quantified older patients' for examined trade-offs they are willing to make accept an alternative model. A discrete choice experiment was conducted among inpatients aged over 60 years with breast, prostate, or colorectal cancer, at two large tertiary hospitals Nantong, China. Preference...
Abstract Background Cancer stem cells (CSCs) are key regulators in the processes of tumor initiation, progression, and recurrence. The mechanism that maintains their stemness remains enigmatic, although role several long noncoding RNAs (lncRNAs) has been highlighted pancreatic cancer (PCSCs). In this study, we first established PCSCs overexpressing lncRNA NORAD, then investigated effects NORAD on maintenance PCSC stemness. Methods Expression miR-202-5p ANP32E PC tissues cell lines was...
Abstract Hepatocellular cancer (HCC) has been reported to belong one of the highly vascularized solid tumours accompanied with angiogenesis human umbilical vein endothelial cells (HUVECs). KDM5A, an attractive drug target, plays a critical role in diverse physiological processes. Thus, this study aims investigate its and underlying mechanisms HCC. ChIP‐qPCR was utilized validate enrichment H3K4me3 KDM5A on promotor region miR‐433, while dual luciferase assay carried out confirm targeting...
Aim: The aim of this meta-analysis was to investigate the relationship between baseline systemic immune inflammatory index (SII) and prognosis in patients with NSCLC. Materials & methods: relation pretreatment SII overall survival, disease-free cancer-specific progression-free survival recurrence-free NSCLC analyzed combined hazard ratio 95% CI. Results: results showed that high significantly correlated patients, but not survival. Conclusion: study suggests a higher has association worse...
Background: The occurrence and development of Hepatic fibrosis (HF) are closely related to the gut microbial composition alterations in host metabolism. Qijia Rougan decoction (QJ) is a traditional Chinese medicine compound utilized clinically for treatment HF with remarkable clinical efficacy. However, its effect on microbiota metabolite unknown. Therefore, our objective was examine impact QJ metabolism Carbon tetrachloride (CCl 4 )-induced HF. Methods: 40% CCl used induce HF, followed by...
Certain pseudogenes may regulate their protein-coding cousins by competing for miRNAs and play an active biological role in cancer. However, few studies have focused on the association of genetic variations with cancer prognosis. We selected six potentially functional single nucleotide polymorphisms (SNPs) cancer-related pseudogenes, performed a case-only study to assess between those SNPs prognosis hepatocellular carcinoma (HCC) 331 HBV-positive HCC patients without surgical treatment....
Gastric cancer is a deadly human malignancy and the molecular mechanisms underlying gastric pathophysiology are very complicated. Thus, further investigations warranted to decipher mechanisms. With development of high-throughput screening bioinformatics, gene expression profiles with large scale have been performed in cancer. In present study, we mined The Cancer Genome Atlas (TCGA) database analyzed between tissues normal tissues. A series differentially expressed lncRNAs, miRNAs mRNAs were...