A5100402701- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Endometrial and Cervical Cancer Treatments
- Traditional Chinese Medicine Analysis
- Cardiovascular Function and Risk Factors
- Neuroscience and Neuropharmacology Research
- Cardiac Imaging and Diagnostics
- Lipid metabolism and disorders
- Drug Transport and Resistance Mechanisms
- Computational Drug Discovery Methods
- Alzheimer's disease research and treatments
- Receptor Mechanisms and Signaling
- Helicobacter pylori-related gastroenterology studies
- Blood groups and transfusion
- Antiplatelet Therapy and Cardiovascular Diseases
- Hormonal and reproductive studies
- Inflammatory Biomarkers in Disease Prognosis
- Cholesterol and Lipid Metabolism
- Pharmaceutical Economics and Policy
Hebei Medical University
2015-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2025
Xiangya Hospital Central South University
2020-2024
Central South University
2020-2024
Fu Wai Hospital
2014-2024
Guiyang Medical University
2022-2024
Chinese People's Liberation Army
2021-2024
Shandong First Medical University
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2017-2024
Affiliated Hospital of Guizhou Medical University
2024
FAM3A belongs to a novel cytokine-like gene family, and its physiological role remains largely unknown. In our study, we found marked reduction of expression in the livers db/db high-fat diet (HFD)-induced diabetic mice. Hepatic overexpression markedly attenuated hyperglycemia, insulin resistance, fatty liver with increased Akt (pAkt) signaling repressed gluconeogenesis lipogenesis those contrast, small interfering RNA (siRNA)-mediated knockdown hepatic resulted hyperglycemia reduced pAkt...
Nonalcoholic fatty liver disease (NAFLD) is characterized by simple hepatic steatosis (SS), nonalcoholic steatohepatitis (NASH), fibrosis, and cirrhosis. Dysregulated acid metabolism in the plays a critical role pathogenesis of NAFLD. Cytochrome P450 omega-hydroxylase 4A14 (CYP4A14) homolog human CYP4A hydroxylase that catalyzes omega-hydroxylation medium-chain acids arachidonic mice. The goal this study was to determine CYP4A14 development progression Here, we showed expression up-regulated...
Glioblastoma multiforme (GBM) in the central nervous system is most lethal advanced glioma and currently there no effective treatment for it. Studies of sinomenine, an alkaloid from Chinese medicinal plant, Sinomenium acutum, showed that it had inhibitory effects on several kinds cancer. Here, we synthesized a sinomenine derivative, sino-wcj-33 (SW33), tested antitumor activity GBM explored underlying mechanism. SW33 significantly inhibited proliferation colony formation reduced migration...
Whether prediabetes mellitus (Pre-DM) alone or combined with hypertension is an independent risk factor for cardiovascular disease has not been fully clarified. This study aimed to further confirm whether the relation of Pre-DM differs between individuals without hypertension. A total 7121 consecutive patients angina-like chest pain who received coronary angiography were evaluated and 4193 angiography-proven stable, new-onset artery enrolled into study. They divided 3 groups according...
Abstract Background Adrenocortical carcinoma (ACC) is an extremely rare, aggressive tumor with few effective therapeutic options or drugs. Mitotane (Mtn), which the only authorized drug, came out in 1970 and still first-line treatment for ACC spite of serious adverse reaction a high recurrence rate. Methods By silico analysis dataset cancer genome atlas (TCGA), we determined that expression levels cyclin-dependent kinase-1 (CDK1) were significantly related to clinical outcomes ACC. In vitro...
Aim: The usefulness of the white blood cell (WBC) count and neutrophil-to-lymphocyte ratio (NLR) in predicting severity stable coronary artery disease (CAD) has not been sufficiently evaluated, particularly based on strict assessments. aim present study was to investigate WBC NLR angiographically proven CAD.Methods: A total 2,976 CAD patients 571 non-CAD were consecutively enrolled, classified into three groups according tertile Gensini score (GS, low GS<18, n=989; intermediate GS 18-41,...
The consumption of tea and herbal infusions has increased rapidly in recent years. More more people consume these as daily beverages well for health purposes. aim this study was to supply new information on the antiproliferative function nutritionists general public. vitro activities 60 different four cancer cell lines were evaluated by MTT assay. results showed that some strongly inhibited proliferation A549 (human lung cells), MCF-7 breast HepG2 hepatoma cells) HT-29 colon decreased...
The notion that tumors lack innervation was proposed several years ago. However, nerve fibers are irregulatedly found in some tumor tissues. Their terminals interaction with cancer cells considered to be neuro-neoplastic synapses. Moreover, neural-related factors, which important players the development and activity of nervous system, have been cells. Thus, they establish a direct connection between system They modulate process metastasis, including degradation base membranes, cell invasion,...
The protein, thyroid hormone-responsive SPOT 14 homolog (Thrsp), has been reported to be a lipogenic gene in cultured hepatocytes, implicating an important role of Thrsp the pathogenesis nonalcoholic fatty liver disease (NAFLD). expression is known regulated by variety transcription factors, including hormone receptor, pregnane X and constitutive androstane receptor. Emerging vitro evidence also points critical receptor (LXR) regulating hepatocytes. In present study, we showed that was...
Herbal medicines are widely used for treating liver diseases and generally regarded as safe due to their extensive use in Traditional Chinese Medicine practice thousands of years. However, recent years, there have been increased concerns regarding the long-term risk Herb-Induced Liver Injury (HILI) patients with dysfunction. Herein, two representative herbal medicines: one-Xiao-Chai-Hu-Tang (XCHT)-a composite formula, other-Radix Polygoni Multiflori (Heshouwu)-a single herb, were analyzed by...
Doxorubicin is a commonly used anthracycline chemotherapeutic agent; however, its application limited owing to cardiotoxicity. Current clinical treatments cannot efficiently or fully prevent doxorubicin-induced toxicity, primarily because pathogenesis and mechanisms of action remain unknown. In this study, we established rat model chronic cardiotoxicity, in which the severity cardiac fibrosis hydroxyproline levels increased time-dependent manner. damaged mitochondria blood vessels induced...
Aim: Recently, monocyte-to-high density lipoprotein ratio (MHR) has been proposed as a novel prognostic indicator of cardiovascular diseases. However, no study is currently available regarding the comparison between MHR and monocyte count (MC) in predicting outcomes among patients undergoing coronary angiography.Methods: A total 3798 scheduled for selective angiography were enrolled followed up to capture major adverse events (MACEs, death, acute myocardial infarction, unstable angina,...
Familial hypercholesterolemia (FH) is characterized by an elevated low-density lipoprotein cholesterol and increased risk of premature coronary artery disease. However, the general picture mutational spectrum FH in China are far from recognized, representing a missed opportunity for investigation.A total 8050 patients undergoing angiography were enrolled. The diagnosis clinical was made using Dutch Lipid Clinic Network criteria, information relatives obtained inquiring probands or their own...