A5100697319- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Reconstructive Surgery and Microvascular Techniques
- Nanoplatforms for cancer theranostics
- Sulfur Compounds in Biology
- Advanced biosensing and bioanalysis techniques
- Breast Implant and Reconstruction
- Reconstructive Facial Surgery Techniques
- Advanced Nanomaterials in Catalysis
- Nitric Oxide and Endothelin Effects
- Aluminum Alloys Composites Properties
- Photodynamic Therapy Research Studies
- Microstructure and mechanical properties
- Nanoparticle-Based Drug Delivery
- Folate and B Vitamins Research
- Water Quality Monitoring and Analysis
- Cancer survivorship and care
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Renal cell carcinoma treatment
- Head and Neck Cancer Studies
- Photoacoustic and Ultrasonic Imaging
- Organ and Tissue Transplantation Research
- Estrogen and related hormone effects
- Advanced X-ray and CT Imaging
Qufu Normal University
2018-2025
Nanjing University
2015-2025
Royal Society of Chemistry
2024
Centre National pour la Recherche Scientifique et Technique (CNRST)
2024
Dalian Institute of Chemical Physics
2023
Chinese Academy of Sciences
2023
First People's Hospital of Chongqing
2023
Hunan Cancer Hospital
2015-2023
Taiyuan University of Technology
2023
Shanghai Jiao Tong University
2018-2023
Grain refinement to the nano/ultrafine-grained regime can make metals several times stronger, but this process is usually accompanied by a dramatic loss of ductility. Such strength-ductility trade-off originates from lack strain-hardening capacity in tiny grains. Here, we present strategy regain ability high-strength incorporation extrinsic nanofillers at grain boundaries. We demonstrate that dislocation storage Cu grains be considerably improved through novel grain-boundary engineering...
Nanograined metals have the merit of high strength, but usually suffer from low work hardening capacity and poor thermal stability, causing premature failure limiting their practical utilities. Here we report a "nanodispersion-in-nanograins" strategy to simultaneously strengthen stabilize nanocrystalline such as copper nickel. Our relies on uniform dispersion extremely fine sized carbon nanoparticles (2.6 ± 1.2 nm) inside nanograins. The intragranular not only elevates strength...
Doxorubicin is a commonly used anthracycline chemotherapeutic agent; however, its application limited owing to cardiotoxicity. Current clinical treatments cannot efficiently or fully prevent doxorubicin-induced toxicity, primarily because pathogenesis and mechanisms of action remain unknown. In this study, we established rat model chronic cardiotoxicity, in which the severity cardiac fibrosis hydroxyproline levels increased time-dependent manner. damaged mitochondria blood vessels induced...
Background Clear cell renal carcinoma (ccRCC) is the most common cancer and it has worst prognosis among all cancers. However, traditional radiological characteristics on computed tomography (CT) scans of ccRCC have been insufficient to predict pathological grade before surgery. Methods Patients with were retrospectively enrolled into this study separated two groups according World Health Organization (WHO)/International Society Urological Pathology (ISUP) grading system, i.e., low-grade...
Endogenous ONOO<sup>−</sup> generation in rheumatoid arthritis mice was visualized and confirmed by the ratiometric fluorescent probe <bold>Ratio-A</bold>.
Abstract The reactive oxygen species (ROS) amplification caused by inevitable plasma albumin encapsulation is still a challenge to circumvent the systemic adverse effects in photodynamic therapy (PDT) process. Herein, disulfide bond linked homodimer, Cy1280, which modulated accurately balance fluorescence and ROS generation exhibit weak sealed PDT effect during blood circulation, exploited. Cy1280 can be specifically internalized dispersed at tumor site via Organic Anion Transporter Proteins...
Two multifunctional colorimetric and fluorescent chemosensors were synthesized by the conjugation of BODIPY (4,4-difluoro-1, 3, 5, 7-tetramethyl-4-bora-3a, 4a-diaza-s-indacene) di(2-picolyl)amine with benzyl groups (para-substituted, L1; meta-substituted, L2) as spacers, for selectively sensing copper(II) ions in preference to a variety other common metal aqueous media. The two analogous compounds exhibit different cytotoxic behaviour attenuate mitochondrial membrane potentials HepG-2 cells....
A modified coaxial electrospinning process was developed for creating drug‐loaded composite nanofibers. Using a mixed solvent of ethanol and N,N‐dimethylacetamide as sheath fluid, the codissolving solution diclofenac sodium (DS) Eudragit L100 (EL100) could run smoothly continuously without any clogging. series analyses were undertaken to characterize resultant nanofibers from both one‐fluid in terms their morphology, physical form components, functional performance. Compared with those...
Phagocyte respiratory burst in immune responses generates enormous amounts of reactive oxygen species (ROS) to fulfill primary defense against neoplasia. However, the beneficial functions associated with ROS, especially potent oxidant/nucleophile peroxynitrite, an immunological process are still ambiguous. Herein, we report construction and biological assessment cyanine-based fluorescent biosensors, which based on a nonoxidative strategy for peroxynitrite detection. The established is...
Programmed cell death (PCD) is a precisely controlled physiological process to sustain tissue homeostasis. Even though the PCD pathways have been explicitly subdivided, individual seems synergistically operate eliminate cells rather than separately execute signal transduction. Apoptosis dominant intracellular subtype, which intimately regulated and by mitochondria, thus tracing mitochondrial actions could reveal dynamic changes of apoptosis, may provide important tools for screening...
Adenosine triphosphate (ATP) is used as the energy source in cells and plays crucial roles various cellular events. The membrane protective barrier for cytoplasm of living involved many essential biological processes. Many fluorescent probes ATP have been successfully developed, but few these were appropriate visualizing level fluctuation cell membranes during apoptotic death process. Herein, we report synthesis a new water-soluble cationic polythiophene derivative that can be utilized...
Endogenous ONOO<sup>−</sup> generation at the early stage of solid tumors was visualized and confirmed assisted by ratiometric fluorescent probe <bold>CDMS</bold>.
Cy 1395 -NPs selectively accumulate in gastric cancer cells through attachment mediated by integrin α v β 3 and target the mitochondria, achieving NIR fluorescence imaging PDT via generation of 1 O 2 under laser irradiation.
Gradient structured materials have been proven to excellent mechanical properties, such as strength–ductility synergy and strain hardening. In this study, the deformation mechanism of heterostructured bulk aluminum with submicron mechanisms was investigated using a mechanism-based strain-gradient plasticity model, whose gradient information obtained discrete computation method. The model then used simulate bending material investigate extra microstructure characterized electron backscattered...
Abstract Small organic molecules which can emit fluorescence with tunable dual emission bands are significant for fundamental research and broad applications. In this work, two binaphthyl based arylacrylonitrile derivatives pyrene triphenylamine unit ( BiNp ‐ Py TPA ) were designed synthesized, respectively, featuring chiral backbone AIE‐active cyanostyrene‐linked chromophores. Excellent emissions in a range of solution solid states observed high quantum yields, indicative the...
Molecular diffusion and leakage impede the long-term retention of probes/drugs may cause potential adverse effects in theranostic fields. Spatiotemporally manipulating organelle-immobilization behavior for prolonged tumor is indispensable to achieving effective cancer diagnosis therapy. Herein, we propose a rational strategy that could realize near-infrared light-activated ribonucleic acids (RNAs) cross-linking simultaneously endogenous hydrogen sulfide (H2S) monitoring colorectal tumors....
Fluorinated polyurethane with fluorinated side chains attached to soft blocks was successfully synthesized, which exhibited unique properties. And also the curing kinetics studied using a rotational rheometer.