A5004761771- Traditional Chinese Medicine Analysis
- Traditional Chinese Medicine Studies
- Pharmacological Effects of Natural Compounds
- Cancer, Hypoxia, and Metabolism
- Medicinal Plant Pharmacodynamics Research
- Mitochondrial Function and Pathology
- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
- Cardiac Fibrosis and Remodeling
- Metabolomics and Mass Spectrometry Studies
- Asthma and respiratory diseases
- Cardiovascular Function and Risk Factors
- Luminescence and Fluorescent Materials
- Circular RNAs in diseases
- Atherosclerosis and Cardiovascular Diseases
- Heat shock proteins research
- Berberine and alkaloids research
- Ginger and Zingiberaceae research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cell death mechanisms and regulation
- Phytochemical Studies and Bioactivities
- Lipid metabolism and disorders
- Retinoids in leukemia and cellular processes
- Neurological Disease Mechanisms and Treatments
- T-cell and B-cell Immunology
Zhejiang Gongshang University
2024
Collaborative Innovation Center of Advanced Microstructures
2016-2023
Nanjing University
2007-2023
Nanjing University of Chinese Medicine
2011-2023
Jiangsu Province Hospital
2008-2022
Google (United States)
2021
Weatherford College
2019
Nanjing Traditional Chinese Medicine Hospital
2019
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2008-2014
Tianjin Hospital
2013
Adenosine triphosphate (ATP), as an important intracellular energy currency produced in mitochondria, is closely related to various diseases living organisms. Currently, the biological application of AIE fluorophore a fluorescent probe for ATP detection mitochondria rarely reported. Herein, D−π–A and D–A structure-based tetraphenylethylene (TPE) fluorophores were employed synthesize six different probes (P1–P6), phenylboronic acid groups dual positive charge sites could interact with vicinal...
Diosgenin, a plant steroid compound from Dioscorea nipponica, is an anti-inflammatory, antidiabetic, antitumor, vasodilatory compound, which also reduces blood lipid content and protects against ischemia‑induced neuronal damage. However, limited number of studies have been performed on the antitumor effect diosgenin prostate cancer, underlying mechanism remains to be fully elucidated. In present study, DU145 human cancer cells was investigated. were cultured in vitro with diosgenin,...
Abstract Immunological tolerance is critical for maintaining gut homeostasis. An imbalance between interleukin-17 (IL-17)-producing T helper 17 (T H 17) cells and regulatory reg cells) involved in ulcerative colitis (UC) pathogenesis. Dendritic (DCs) are able to induce cell differentiation. Paeoniflorin (PF) a monoterpene glucoside that commonly used treatment of autoimmune disease. However, the immunological mechanism PF involvement UC unclear. The present study aimed explore whether can...
Proanthocyanidins are flavonoids that widely present in the skin and seeds of various plants, with highest content grape seeds. Many experiments have shown proanthocyanidins antitumor activity both vivo vitro. Autophagy apoptosis tumor cells induced by drugs two major causes cell death. However, reports on effect autophagy not consistent suggest can synergistic or antagonistic effects apoptosis. This research was aimed at investigating whether human gastric cancer line MGC-803 to identify...
Adenosine triphosphate (ATP) is used as the energy source in cells and plays crucial roles various cellular events. The membrane protective barrier for cytoplasm of living involved many essential biological processes. Many fluorescent probes ATP have been successfully developed, but few these were appropriate visualizing level fluctuation cell membranes during apoptotic death process. Herein, we report synthesis a new water-soluble cationic polythiophene derivative that can be utilized...
Gastric cancer is one of the most common malignant tumors in world. Due to lack early diagnosis and effective treatment, outcome treatment prognosis poor. MicroRNA‑145 (miR‑145) downregulated various types. In present study, miR‑145 expression was detected by reverse transcription‑quantitative polymerase chain reaction gastric cell lines normal epithelial cells. The function line SGC‑7901 investigated. results demonstrated that Further analysis identified upregulation significantly...
The present study aimed to investigate the antiatherosclerotic effect of rhizoma polygonati polysaccharide. Adult golden hamsters (<i>Mesocricetus auratus</i>) were fed an atherosclerotic diet containing 1.5 mL olive oil, 8 mg (320 000 IU) vitamin D<sub>2</sub>, and 40 cholesterol for 60 consecutive days induce atherosclerosis. These then orally received either reference drug simvastatin (5 mg/kg) or polysaccharide (0.57 g/kg 1.14 g/kg) once daily additional before comparison normal...
Abstract Cell death in the central nervous system causes neurologic diseases, which reactive oxygen species (ROS) play a critical role by either inducing cellular oxidative stress or increasing cell tolerance against insult. Neurologic diseases may potentially be treated regulating ROS levels certain range with small molecules. We studied preconditioning two polynitrogen manganese complexes ( 1 and 2 ) to regulate intracellular protection of both differentiated rat pheochromocytoma line...
Hypertensive renal damage is a chronic and life-threatening kidney disease all over the world. The traditional Chinese medicine Jiang Ya Yi Shen (JYYS) granule has been perfect drug for patients with hypertensive injury in clinic 20 years China. However, molecular mechanism of JYYS remains unknown treatment this disease.The data were from study's patients. clinical symptoms indicated by (N-Acetyl-β-D-Glucosaminidase) NAG, (albumin) Alb, (β2-microglobin) β2-MG content urinary patients,...
Many infertile women suffered from poor ovarian response, and increased reactive oxygen species with age might mediate the response to FSH.In this study, we collected follicular fluids isolated granulosa cells female patients.Increased levels of peroxynitrite, tyrosine nitrations FSH receptor (FSHR) apoptosis were obviously detectable decreased FSHR protein expressions in responders.In KGN (a human cell line) cells, exogenous peroxynitrite could sequester cytoplasm, these dislocated suffer...
Coronary heart disease (CHD) has been regarded as a serious and common in the modern society. This study aims to investigate effect of Granule BU-XIN RUAN-MAI (BXRM) on angina pectoris coronary explore molecular mechanisms underlying RUAN-MAI-mediated protective activity against this disease.The effects clinical symptoms patients' were indicated by hemorheology indicators including high shear blood viscosity, low plasma erythrocyte rigidity index, D-D dimer, fibrinogen content, lipid...
Sesquiterpenoids are a major type of compound found in Solanum lyratum (S. lyratum). The present study aimed to investigate whether sesquiterpenoids from S. demonstrated cytotoxicity against the MCF-7, HCT-8, A-549, SGC-7901 and BEL-7402 cell lines, mechanism solajiangxin H lyratol D, which exhibited high cells (half maximal inhibitory concentration, IC50=4.8 5.9 µg/ml), was associated with mitochondria-mediated apoptosis. results Cell Counting Kit-8 assay indicated that 15 had...
Protection against hypoxia injury is an important therapeutic strategy for treating hypertensive nephropathy. In this study, the effects of Qian Yang Yu Yin granule (QYYY) on spontaneously rats fed with high salt diet and HEK293T cells exposed to were investigated. After eight weeks’ treatment QYYY, blood pressure, serum creatinine, cystatin C, urea nitrogen, urinary β2-microglobulin, N-acetyl-β-glucosaminidase, microalbumin assessed. The changes hypoxia-inducible factor-1α (HIF-1α),...
This study aimed to comprehensively investigate the potential active components and therapeutic mechanisms of Shen-Kui-Tong-Mai granule (SKTMG) in treatment heart failure.Network pharmacology combined with ultra-high performance liquid chromatography coupled tandem mass spectrometry (UHPLC-MS/MS), molecular docking, vivo validation was performed identify targets for SKTMG improve chronic failure (CHF).The network identified 192 compounds 307 consensus SKTMG. On other hand, analysis...
A high-salt diet often leads to a local intrarenal increase in renal hypoxia and oxidative stress, which are responsible for an excess production of pathogenic substances. Here, Wistar Kyoto/spontaneous hypertensive (WKY/SHR) rats fed developed severe proteinuria, resulting from pronounced inflammation, fibrosis tubular epithelial cell apoptosis. All these were mainly non-pressure-related effects. Hsp90β, TGF-β, HIF-1α, TNF-α, IL-6 MCP-1 shown be highly expressed response salt loading. Next,...
Allergic asthma is an inflammatory disease involving the Th1/Th2 cell imbalance in peripheral blood. Repeated herbal acupoint sticking (RHAS) has been used for hundreds of years China to relieve recurrence allergic asthma, and it still practiced today. Thus, we explored effect on relapse underlying immunoregulatory mechanism this study. Here, enrolled 50 participants, 38 them completed treatment follow-up (the group). In addition, 13 healthy participants control group) were enrolled. The...