A5100432258- Geology and Paleoclimatology Research
- Geological and Geophysical Studies
- Geological formations and processes
- Tree-ring climate responses
- earthquake and tectonic studies
- Mesenchymal stem cell research
- Glaucoma and retinal disorders
- Geological and Geochemical Analysis
- Planarian Biology and Electrostimulation
- Neonatal Respiratory Health Research
- Traditional Chinese Medicine Analysis
- Retinal Imaging and Analysis
- Salivary Gland Disorders and Functions
- Retinal Diseases and Treatments
- Pharmacological Effects of Natural Compounds
- Renal Transplantation Outcomes and Treatments
- Pharmacological Effects and Toxicity Studies
- Cardiovascular Function and Risk Factors
- Cholinesterase and Neurodegenerative Diseases
- Peptidase Inhibition and Analysis
- Medicinal Plants and Neuroprotection
- Nanomaterials and Printing Technologies
- Ocular Infections and Treatments
- Tree Root and Stability Studies
- Diabetes Treatment and Management
Institute of Geology, China Earthquake Administration
2020-2024
Nanjing University of Chinese Medicine
2023-2024
Jiangsu Province Hospital
2019-2024
China Earthquake Administration
2017-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2024
Tsinghua University
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2023-2024
Shanxi Eye Hospital
2023-2024
Northwest University
2023-2024
Beijing University of Chemical Technology
2023
Abstract Possessing the largest surface area of mucosa in body, gastrointestinal (GI) tract can easily sufferfrom inflammatory damage under various adverse external exposures, resulting occurrence bowel disease (IBD). Excessive reactive oxygen species (ROS) usually lead to local mucosal injury, accelerate formation niduses, andamplify and immune response. Antioxidant therapy, therefore, is considered as a potential strategy against IBDs. Herein, series novel dihydromyricetin‐based...
Neuropathic pain is a serious clinical problem that needs to be solved urgently. ASK1 an upstream protein of p38 and JNK which plays important roles in neuroinflammation during the induction maintenance chronic pain. Therefore, inhibition may novel therapeutic approach for neuropathic Here, we aim investigate effects paeoniflorin on The mechanical thermal thresholds rats were measured using Von Frey test. Cell signaling was assayed western blotting immunohistochemistry. Chronic constrictive...
Abstract Background Organ replacement regenerative therapy based on human adult stem cells may be effective for salivary gland hypofunction. However, the generated tissues are immature because signaling factors that induce differentiation of into glands unknown. Methods Isolated submandibular stem/progenitor (hSMGepiS/PCs) were characterized and three-dimensionally (3D) cultured to generate organoids further induced by fibroblast growth factor 10 (FGF10) in vitro. The spheres alone or...
Vegetation plays an important role in ecosystem stability tectonically active regions such as the eastern Tibetan Plateau (ETP). To determine response of mountain to climate change and tectonic activity on ETP, detailed analyses chronology, pollen, grain size magnetic susceptibility (SUS) were conducted a lacustrine sequence from upper reaches Min River. The results show that sediments are mainly transported by wind those seismogenic dust at Diexi Lixian. fine–grained (<20 μm) background was...
Lacustrine sediments on the eastern Tibetan Plateau (TP) contain a wealth of information local and regional tectonic activity. High-resolution grain-size magnetic susceptibility measurements were conducted 23.4-m-thick Lixian lacustrine sedimentary sequence spanning from 19.3 to 6.0 ka, revealing 70 prehistoric seismic events TP. The caused intermittent increases in source materials that endowed samples an individual event layer with gradual fining trend along C = M line (one percentile)-M...
Organophosphorus pesticides (OPs) are a chemically diverse class of commonly used insecticides. Epidemiological studies suggest that low dose chronic prenatal and infant exposures can lead to life-long neurological damage behavioral disorders. While inhibition acetylcholinesterase (AChE) is the shared mechanism acute OP neurotoxicity, OP-induced developmental neurotoxicity (DNT) occur independently and/or in absence significant AChE inhibition, implying OPs affect alternative targets....
Moisture evolution in Central Asia including Northwest China shows less similarity with its surroundings and attracts a growing number of studies. In this study, well-dated thick lacustrine sequence is chosen detailed geochemical analysis conducted during the Middle Miocene Climate Transition (MMCT, 14–11 Ma). The multi-proxy records (Na 2 O/Al O 3 , CIA, Rb/Sr) revealed that chemical weathering was strongest 11.85–11 Ma, coldest period Ma as evidenced by global deep-sea oxygen isotope...
The quantitative detection of drug-resistance mutations in Mycobacterium tuberculosis (MTB) is critical for determining the drug resistance status a sample. We developed drop-off droplet digital PCR (ddPCR) assay targeting all major isoniazid (INH)-resistant mutations. ddPCR consisted three reactions: reaction A detects at katG S315; B inhA promoter mutations; and C ahpC All reactions could quantify 1%-50% mutants presence wild-type, ranging from 100 to 50,000 copies/reaction. Clinical...
Abstract The association of cardio‐ankle vascular index (CAVI), with subclinical cardiac dysfunction in hypertensive patients is unclear. We aim to examine their relationship compared that normotensive subjects. Our study included 1887 subjects enrolled from Danyang between 2018 and 2019. CAVI was measured using VaSera VS‐1500A device. performed conventional echocardiography measure ejection fraction (EF) E/A, tissue Doppler mitral annular early diastolic velocities (e’), speckle‐tracking...
Several bone diseases, including arthritis, fracture and osteoporosis, have a pathophysiologically important inflammatory component. Sustained inflammation can result in delayed healing. Therefore, to promote repair, it is inhibit erosion suppress pro-inflammatory mediators. In this study, aspirin significantly enhanced immunomodulation osteogenic differentiation human mesenchymal stem cells (hMSCs). Additionally, an BFP-1 peptide-decorated substrate (PS-PEP) of aspirin-treated hMSCs...
Glutaredoxin 2 (Grx2), a mitochondrial glutathione-dependent oxidoreductase, is crucial for maintaining redox homeostasis and cellular functions in the lens. The oxidative stress-induced epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) related to posterior capsule opacification. In this study, we investigated effects Grx2 on EMT LECs during We found that expression was substantially decreased mouse model cataract surgery. Deletion aggravated generation reactive oxygen...
Cryogenic CMOS (Cryo-CMOS) ASICs have drawn increasing attention with great potential in scaling down the quantum computing (QC) platform. Recently, several cryoCMOS been presented literature, including qubit state readout [1–4] and controller [5–8]. For ASICs, quadrature conversion architecture is widely adopted, power consumption ranging from 20mW [1] to 75mW [2]. Also, significant progress has made reducing of controllers. The [5] consumes a <4 mW/qubit under active control, when...
Diabetic retinopathy (DR) is the leading cause of vision loss and blindness among working-age adults. Pericyte an early pathological feature DR. Under hyperglycemic conditions, reactive oxygen species (ROS) production increases, to oxidative stress subsequent mitochondrial dysfunction apoptosis. Dysfunctional pericyte can retinal vascular leakage, obliteration, neovascularization. Glutaredoxin 2 (Grx2) a glutathione-dependent oxidoreductase which protects cells against insults by...
Aortic valve calcification is more prevalent in chronic kidney disease accompanied by hypercalcemia. Secreted protein acidic and rich cysteine (SPARC)-related modular calcium binding 1 (SMOC1) a regulator of BMP2 signalling, but the role SMOC1 aortic under different conditions has not been studied. This study aimed to investigate roles normal high conditions, focusing on effects interstitial cells (AVICs).SMOC1 was expressed endothelial secreted into extracellular matrix non-calcific valves...
CYP3A4, CYP3A5, and CYP3A7, which are located in a multigene locus (CYP3A), play crucial roles drug metabolism. To understand the highly variable hepatic expression of CYP3As, regulatory network analyses have focused on transcription factors (TFs). Since long non-coding RNAs (lncRNAs) likely contribute to such networks, we assessed effects both TFs lncRNAs CYP3A human liver small intestine, main organs expression. Using weighted gene co-expression analysis (WGCNA) GTEx v8 RNA data multiple...
This study aimed to comprehensively investigate the potential active components and therapeutic mechanisms of Shen-Kui-Tong-Mai granule (SKTMG) in treatment heart failure.Network pharmacology combined with ultra-high performance liquid chromatography coupled tandem mass spectrometry (UHPLC-MS/MS), molecular docking, vivo validation was performed identify targets for SKTMG improve chronic failure (CHF).The network identified 192 compounds 307 consensus SKTMG. On other hand, analysis...
The comorbidities of coronary artery disease (CAD) and rheumatoid arthritis (RA) are mutual risk factors, which lead to higher mortality, but the biological mechanisms connecting two remain unclear. Here, we aimed identify genes for comorbid presence these complex diseases using a network modularization approach, offer insights into clinical therapy drug development diseases.The expression profile data patients CAD with without RA were obtained from GEO database (GSE110008). Based on...
The aim of this study was to analyze the relationship between diopter (D) and choroidal thickness in myopic children by describing values thickness, explore as an important indicator for evaluating progression myopia.The included emmetropic aged 6-14 years (156 eyes) from Second Hospital Dalian Medical University. participants were divided into four groups according spherical equivalent refraction (SER): low myopes, moderate high emmetropes. Choroidal measured nine areas using Early...