A5100365975- Connexins and lens biology
- Intraocular Surgery and Lenses
- PI3K/AKT/mTOR signaling in cancer
- Biochemical effects in animals
- Pancreatic and Hepatic Oncology Research
- Advanced Glycation End Products research
- Cancer, Hypoxia, and Metabolism
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Glaucoma and retinal disorders
- Healthcare and Venom Research
- Cancer-related molecular mechanisms research
- Acupuncture Treatment Research Studies
- Chronic Lymphocytic Leukemia Research
- Bioinformatics and Genomic Networks
- Cancer Cells and Metastasis
- Cell death mechanisms and regulation
- Aldose Reductase and Taurine
- Redox biology and oxidative stress
- Corneal surgery and disorders
- RNA modifications and cancer
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Blood transfusion and management
- Retinal Diseases and Treatments
- Sulfur Compounds in Biology
Shanxi Eye Hospital
2022-2025
Northwest University
2023-2025
Sichuan University
2024-2025
Northwestern Polytechnical University
2020-2024
Shanghai Institute of Pharmaceutical Industry
2024
West China Second University Hospital of Sichuan University
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2023-2024
Central Hospital of Wuhan
2021-2023
Affiliated Hospital of Southwest Medical University
2023
Huazhong University of Science and Technology
2023
li x.‐m., zhou k.‐n., yan h., wang d.‐l. & zhang y.‐p. (2011) Effects of music therapy on anxiety patients with breast cancer after radical mastectomy: a randomized clinical trial. Journal Advanced Nursing 68 (5), 1145–1155. Abstract Aim. This paper is report trial the effects female following mastectomy. Background. There insufficient evidence state Methods. A Hall’s Core, Care, and Cure Model‐based was conducted in 120 from March to November 2009. controlled design utilized. The were...
Hepatic stellate cells (HSCs) are the primary source of matrix components in liver disease such as fibrosis. Phosphatidylinositol 3-kinase (PI3K) signaling HSCs has been shown to induce fibrogenesis. In this study, we evaluated anti-fibrotic activity a novel imidazopyridine analogue (HS-173) human well mouse HS-173 strongly suppressed growth and proliferation induced arrest at G2/M phase apoptosis HSCs. Furthermore, it reduced expression extracellular collagen type I, which was confirmed by...
Substantial alterations at the multi-omics level of pancreatic cancer (PC) impede possibility to diagnose and treat patients in early stages. Herein, we conducted an integrative omics-based translational analysis, utilizing next-generation sequencing, transcriptome meta-analysis, immunohistochemistry, combined with statistical learning, validate multiplex biomarker candidates for diagnosis, prognosis, management PC. Experiment-based validation was supportive evidence essentiality PC were...
Cataract is a blinding disease worldwide. It an age-related that mainly occurs in people over 65 years old. also prevalent patients with diabetes mellites (DM). The pathological mechanisms underlying diabetic cataract (DC) are more complex than of cataract. Studies have identified polyol pathway, advanced glycation end products (AGEs) and oxidative stress the primary pathogenesis DC. In recent years, molecular-level regulations processes lens epithelial cells (LECs) been confirmed to play...
ABSTRACT Respiratory syncytial virus (RSV) causes severe acute lower respiratory tract infections, especially in infants and the elderly. Developing an RSV vaccine that promotes a robust mucosal immune response is necessary to successfully prevent viral transmission development of disease. We previously reported crosslinked carbon dots (CCD) may be excellent adjuvant candidate for intranasal (IN) protein subunit vaccines. Considering strong immunogenicity prefused F (preF), we prepared IN...
Purpose.: To study the effect of age on morphologic and biochemical alterations induced by in vivo exposure ultraviolet radiation (UV). Methods.: Young old C57BL/6 mice were exposed to broadband UVB+UVA euthanized after 2 days. Another batch UV-exposed young was monitored for changes 1, 2, 4, 8 Age-matched nonexposed served as controls. Lens documented slit-lamp biomicroscopy dark field microscopy photographs ex vivo. homogenates analyzed glutathione (GSH) level, activities thioredoxin...
Cancer stem cells (CSCs) possess high tumor-initiating capacity and have been reported to be resistant therapeutics. Vice versa, therapy-resistant cancer seem manifest CSC phenotypes properties. It has generally assumed that drug-resistant may all CSCs although the generality of this assumption is unknown. Here, we chronically treated Du145 prostate with etoposide, paclitaxel some experimental drugs (i.e., staurosporine 2 analogs), which led populations drug-tolerant (DTCs). Surprisingly,...
B-cell lymphoma 6 (BCL6) protein, an evolutionarily conserved zinc finger transcription factor, showed to be highly expressed in various human cancers addition malignancies the lymphoid system. This study investigated role of BCL6 expression breast cancer and its clinical significance patients. Expression protein was assessed using situ hybridization immunohistochemistry 127 patients 50 with benign disease as well cell lines. restored or knocked down two lines (MCF-7 T47D) cDNA siRNA,...
// Nguyen Phuoc Long 1 , Kyung Hee Jung 2 Sang Jun Yoon Hoang Anh 3 Tran Diem Nghi Yun Pyo Kang Hong Hua Yan Eun Min Soon-Sun and Sung Won Kwon 1, 4 College of Pharmacy, Seoul National University, 08826, Korea Department Drug Development, Medicine, Inha Incheon 22212, School Vietnam Ho Chi Minh 70000, Research Institute Pharmaceutical Sciences, Correspondence to: Kwon, email: swkwon@snu.ac.kr Hong, hongs@inha.ac.kr Keywords: cervical cancer; transcriptomics; deep learning; meta-analysis;...
SB365, Pulsatilla saponin D isolated from the root of koreana , has exhibited potential beneficial effects as a chemopreventive agent for critical health conditions including cancer. However, molecular mechanisms underlying activity SB365 remain unknown. Here, we examined anticancer efficacy against gastric cancer and its mechanism action. effectively inhibited growth cells. Its apoptotic effect was accompanied by increased evidence cleaved caspase-3 poly(ADP ribose) polymerase. To elucidate...