A5070231143- Polyomavirus and related diseases
- MicroRNA in disease regulation
- Bacteriophages and microbial interactions
- Plant Virus Research Studies
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Diet and metabolism studies
- RNA Research and Splicing
- Antenna Design and Analysis
- Full-Duplex Wireless Communications
- Liver Disease Diagnosis and Treatment
- RNA Interference and Gene Delivery
- Berberine and alkaloids research
- Lipid metabolism and disorders
- Platelet Disorders and Treatments
- Cell Adhesion Molecules Research
- Phytochemistry and biological activity of medicinal plants
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genomics and Chromatin Dynamics
- Pharmacogenetics and Drug Metabolism
- Extracellular vesicles in disease
- Chemical Reactions and Isotopes
- Diabetes Treatment and Management
- Natural Compounds in Disease Treatment
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2018-2025
National Institutes of Health
2016-2025
Ningbo University
2018-2025
Xinjiang Medical University
2024
Shanghai Institute of Materia Medica
2012-2018
Chinese Academy of Sciences
2011-2018
National Cancer Institute
2016-2018
Center for Cancer Research
2018
University of Chinese Academy of Sciences
2017
Hebei Medical University
2015
Multidrug resistance-associated protein 1 (MRP1) is an important efflux transporter and overexpression of MRP1 usually leads to chemoresistance in breast cancer. Here, we found overexpressed human cancer tissues cell lines (compared with normal line, respectively). And level increased doxorubicin resistant MCF-7 cells compared parental cells. Increasing evidences suggest microRNAs (miRNAs) influence chemotherapy response. We miR-145 decreased tissues, cells, inversely correlated expression...
Racial and ethnic differences in skin cancer outcomes are understudied. Delineating these Merkel cell carcinoma (MCC) is needed to better understand this rare disease.
MicroRNAs (miRNAs) are a class of small non-coding RNAs, which direct post-transcriptional gene silencing (PTGS) and function in vast range biological events including cancer development. Most miRNAs pair to the target sites through seed region near 5' end, leading mRNA cleavage and/or translation repression. Here, we demonstrated miRNA-induced dual regulation heme oxygenase-1 (HO-1) via non-seed region, consequently inhibited tumor growth NSCLC. We identified miR-1254 as negative regulator...
The Sonic hedgehog (Shh) signaling pathway regulates developmental, homeostatic, and repair processes throughout the body. In skin, touch domes develop in tandem with primary hair follicles contain sensory Merkel cells. developmental requirements for dome specification are largely unknown. We found dermal Wnt subsequent epidermal Eda/Edar promoted cell morphogenesis by inducing Shh expression early follicles. Lineage-specific gene deletions revealed intraepithelial was necessary...
Merkel cell carcinoma (MCC) and small lung cancer (SCLC) can be histologically similar. Immunohistochemistry (IHC) for cytokeratin 20 (CK20) thyroid transcription factor 1 (TTF-1) are commonly used to differentiate MCC from SCLC; however, these markers have limited sensitivity specificity. To identify new diagnostic markers, we performed differential gene expression analysis on transcriptome data SCLC tumors. Candidate included atonal BHLH (ATOH1) AP-2β (TFAP2B) MCC, as well carcinoembryonic...
Klinefelter's syndrome (KS) is the most common sex chromosome disorder in male population and characterized by presence of one or more X chromosomes. Studies have reported that proportion KS patients with diabetes not low. It also uncommon for poorly controlled blood glucose to a transient mild increase their carcinoembryonic antigen (CEA) levels. This study reports case Diabetic ketoacidosis (DKA) concurrently significant CEA levels (reaching 40.8 ng/mL) KS. middle-aged patient was...
Abstract Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer. Most MCCs contain polyomavirus (virus-positive MCC; VP-MCC), and the remaining are virus-negative (VN-MCC). Immune checkpoint inhibitors first-line treatment for metastatic MCC, but durable responses achieved in less than 50% of patients. To identify new treatments, we screen ~4,000 compounds their ability to reduce MCC viability demonstrate that VP-MCC VN-MCC exhibit distinct response profiles. Aurora kinase selectively...
Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer that responds to PD-1/PD-L1 immune checkpoint inhibitors. CD200 another modulator whose receptor found on tumor-promoting myeloid cells, including M2 macrophages. We high mRNA expression in MCC tumors, immunostaining was demonstrated 95.5% of tumors. CD200R-expressing cells were present the tumor microenvironment. MCC-associated macrophages had higher average CD163:CD68 staining ratio (2.67) than controls (1.13), indicating an...
The aim of the present study was to examine role protease-activated receptor-1 (PAR1)-stimulated platelet activation in epithelial-mesenchymal transition (EMT) and migration colon cancer cells, identify underlying mechanisms. TFLLR-NH2, a PAR1 agonist, used activate platelets supernatants were treat SW620 cell line. Expression E-cadherin vimentin on cells detected by immunofluorescence western blotting, level transforming growth factor β1 (TGF-β1) measured using ELISA following TFLLR-NH2....
Mouse cytochrome P450 2b9 (Cyp2b9) is a testosterone 16<i>α</i>-hydroxylase enzyme showing female-specific expression in many inbred mouse strains, including C57BL/6J. Previous studies have recognized that some sex-dependently secreted endogenous modulating factors were involved the sexually dimorphic of Cyp2b9 through transcriptional regulation. In this study, we found evidence microRNAs contributed to biased via post-transcriptional was upregulated livers hepatocyte-specific Dicer1...
Genotoxicity assessment is of great significance in drug safety evaluation, and microarray a useful tool widely used to identify genotoxic stress responsive genes. In the present work, by using oligonucleotide an vivo model, we identified unknown gene BC005512 (abbreviated as BC, official full name: cDNA sequence BC005512), whose expression mouse liver was specifically induced seven well-known genotoxins (GTXs), but not non-genotoxins (NGTXs). Bioinformatics revealed that BC member GLN...
ABSTRACT Index hopping causes read assignment errors in data from multiplexed sequencing libraries. This issue has become more prevalent with the widespread use of high-capacity sequencers and highly single-cell RNA (scRNA-seq) We conducted deep, plate-based scRNA-seq on a mixed population mouse skin cells. Analysis transcriptomes 1152 cells identified four distinct cell types. To estimate error rate sample due to index hopping, we employed differential expression analysis identify signature...