A5037195175- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Mechanisms and Therapy
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Cancer Immunotherapy and Biomarkers
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Liver physiology and pathology
- Cancer, Lipids, and Metabolism
- Angiogenesis and VEGF in Cancer
- Microtubule and mitosis dynamics
- Vascular Anomalies and Treatments
- Nanoplatforms for cancer theranostics
- Cardiac Valve Diseases and Treatments
- Advanced Radiotherapy Techniques
- COVID-19 and healthcare impacts
- Viral-associated cancers and disorders
- Lung Cancer Treatments and Mutations
- Organ Transplantation Techniques and Outcomes
- Lung Cancer Research Studies
- COVID-19 Clinical Research Studies
Union Hospital
2013-2025
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2018-2025
Huazhong University of Science and Technology
2015-2025
First Affiliated Hospital of GuangXi Medical University
2025
Guangxi Medical University
2025
Union Hospital
2010-2024
Wuhan Union Hospital
2018-2024
Central South University
2024
Shandong University
2013-2024
Shandong Provincial Hospital
2013-2024
A Mediterranean-style diet (MED) can promote people lengthen the span of life and avoid atherosclerotic cardiovascular disease (ASCVD) in primary prevention. Metabolic syndrome (MetS) significantly reduce expectancy increase risk ASCVD. However, few studies have focused on role Mediterranean patients with MetS. Participants National Health Nutrition Examination Survey (NHANES) MetS (N = 8301) from 2007 to 2018 were examined. 9-point evaluation scorewas used measure degree adherence MED diet....
Abstract Metastasis accounts for the majority of cases cancer recurrence and death in patients with advanced non-small cell lung (NSCLC). Farnesoid X Receptor (FXR) is a bile acid nuclear receptor that was recently found to be upregulated NSCLC tissues. However, whether how FXR regulates metastasis remains unclear. In present study, it promoted migration, invasion, angiogenic ability cells vitro, increased mouse model vivo. Mechanistic investigation demonstrated specifically bound promoters...
AIM:To investigate the effect of omega-3 fatty acid parenteral supplementation postoperatively on clinical outcomes and immunomodulation in colorectal cancer patients. METHODS:Forty-two patients undergoing radical resection with an indication for total nutrition were enrolled this prospective, double-blind, randomized, controlled study.Patients received supplemented either soybean oil (LCT; Intralipid ® , Fresenius-Kabi, SO group, n = 21) or a combination fish (LCT:fish 5:1, oil; Omegaven FO...
The lack of noninvasive tracking and mapping the fate embolic agents has restricted development further applications transcatheter arterial embolization (TAE) therapy. In this work, inherent radiopaque material, barium alginate (ALG) microspheres loaded with in situ synthesized BaSO4 (denoted as BaSO4/ALG microspheres), have been by a one-step droplet microfluidic technique. One advantages our approach is that form nanoparticles well dispersed inside ALG microspheres, thereby greatly...
To further assess the early and mid-term outcomes of thoracic endovascular aortic repair (TEVAR) in patients with acute uncomplicated type B dissection (TBAD) compared those receiving best medical treatment (BMT).Between February 2008 March 2018, 357 consecutive TBAD were retrospectively analyzed. Among them, 191 underwent TEVAR, 166 received BMT. After propensity score matching, we obtained 145 matched pairs for analysis.In population, 30-day mortality between TEVAR group BMT showed no...
Abstract Background The prognostic significance of the CRAFITY score ( CR P and AF in I mmuno T herap Y ) has been demonstrated hepatocellular carcinoma (HCC) patients receiving immunotherapy. purpose this study was to investigate utility predictive value HCC after transarterial chemoembolization (TACE) combination with tyrosine kinase inhibitors (TKIs) Materials methods Data from advanced treated TACE plus TKIs PD-1 inhibitor January 2019 June 2022 were collected analyzed retrospectively....
The mechanism of postoperative nausea and vomiting after TACE is not clear. This study retrospectively analyzed the patient data to explore risk factors TACE.The 221 patients who underwent in interventional department from January 2019 December 2020 were collected. Including: gender, age, liver function before TACE, etiology cirrhosis, BCLC stage hepatocellular carcinoma, preoperative use analgesic drugs, limosis, previous history vomiting, kinetosis, smoking history, drinking,...
To assess the safety and efficacy of local ablation plus PD-1 inhibitor toripalimab in previously treated unresectable hepatocellular carcinoma (HCC).In multicenter, two-stage, randomized phase 1/2 trial, patients were randomly assigned to receive alone (240 mg, every 3 weeks), subtotal followed by starting on post-ablation day (Schedule D3), or 14 D14). The first endpoint stage 1 was determine which combination schedule could continue progression-free survival (PFS) as primary for 1/2.A...
Background & Aims:The effect of transarterial chemoembolization (TACE) plus radiofrequency ablation (RFA) (TACE-RFA) for hepatocellular carcinoma (HCC) in high-risk locations is not satisfactory.The aim this study was to compare the clinical outcomes TACE-RFA iodine-125 ( 125 I) seed implantation (TACE-RFA-125 therapy with those unresectable HCC (≤5 cm) locations.Methods: From January 2010 June 2023, data 126 patients who received TACE-RFA-125 I or treatment were retrospectively analyzed.The...
Chronic obstructive pulmonary disease (COPD) pathogenesis is influenced by environmental factors, including Benzo(a)pyrene (BaP) exposure. This study aims to identify BaP-related toxicological targets and elucidate their roles in COPD development. A comprehensive bioinformatics approach was employed, the retrieval of from Comparative Toxicogenomics Database (CTD) Super-PRED database, identification differentially expressed genes (DEGs) GSE76925 dataset, protein-protein interaction (PPI)...
Background: Apatinib is a powerful inhibitor of vascular endothelial growth factor receptor-2. This study was aimed to investigate whether apatinib could improve the efficacy transarterial chemoembolization (TACE) in patients with advanced hepatocellular carcinoma (HCC). Methods: Between June 2015 and September 2018, 357 HCC at Barcelona Clinic Liver Cancer stage C who received treatment TACE combining (TACE-apatinib) or TACE-alone were included. Propensity score matching (PSM) analysis used...
Abstract Purpose The goal of this study was to define a new homogeneity index (HI) evaluate dose within target volume. Materials and Methods HI is based on the area under an ideal dose‐volume histogram curve (IA), achieved (AA), overlapping between IA AA (OA). It defined as ratio square OA product AA. To performance HI, 88 cases were selected two plans designed for each case. first evaluated by three physicists, with their judgments forming evaluation standard then other HIs D max / p , 5 95...
To compare the efficacy and safety of TACE combined with Donafenib Toripalimab versus Sorafenib in treatment unresectable hepatocellular carcinoma (HCC), aiming to guide personalized strategies for HCC improve patient prognosis.A retrospective analysis was conducted on clinical data 169 patients advanced-stage who underwent at Interventional Department Wuhan Union Hospital from January 2020 December 2022. Based patients' strategies, they were divided into two groups: + group (N = 81) 88)....
Radiofrequency ablation (RFA) has been used as an alternative to surgical management of early-stage hepatocellular carcinoma (HCC). However, when large and irregular HCCs are subjected RFA, a safety margin is usually difficult obtain, thus causing sublethal radiofrequency hyperthermia (RFH) at the ablated tumor margin. This study investigated feasibility using RFH enhance effect OK-432 on HCC, with aim generate tumor-free during RFA HCC. Our results showed could activate cGAS-STING pathway,...
Background CalliSpheres are drug‐eluting beads used for tumor artery embolization, with clinical benefits in a number of cancer types. The aim the study was to examine and complications patients stage II–IV lung treated embolization versus conventional vascular interventional treatment. Methods This prospective cohort conducted from August 2018 May 2019. were grouped according traditional bronchial arterial infusion chemotherapy (infusion group) or chemoembolization loaded adriamycin...
This study aimed to compare the efficacy and safety between transarterial chemoembolization (TACE) with CalliSpheres® microspheres (CSM-TACE) conventional TACE (cTACE) in patients hepatocellular carcinoma (HCC). Three hundred thirty-five HCC receiving CSM-TACE or cTACE were consecutively enrolled this multi-center, retrospective cohort study, then divided into group accordingly. Complete response (CR), objective (ORR) disease control (DCR) was assessed according mRECIST criteria at 1 month...
Abstract Objective To investigate the efficacy of an injectable hydrogel loaded with lysed OK-432 (lyOK-432) and doxorubicin (DOX) for residual liver cancer after incomplete radiofrequency ablation (iRFA) hepatocellular carcinoma (HCC), explore underlying mechanism. Materials Methods The effect lyOK-432 was compared in activating dendritic cells (DCs). RADA16-I (R) peptide dissolved a mixture (O) DOX (D) to develop ROD hydrogel. characteristics were evaluated. Tumor response mice survival...
Transcatheter intraarterial techniques can effectively deliver chemotherapeutic agents to tumor and improve the efficacy of chemotherapy. The present study is designed evaluate effect transcatheter on distribution doxorubicin in relation blood vessels liver cancer.VX2 tumors were implanted livers 32 rabbits. animals divided into 4 groups 8 each. Group 1 (doxo iv) received intravenous injection; group 2 ia) hepatic infusion; 3 ia + E) infusion followed by embolization; L mixed with Lipiodol...
Abstract Background Streptococcus agalactiae or group B (GBS) is a leading infectious cause of neonatal morbidity and mortality. It essential to establish robust method for the rapid ultra-sensitive detection GBS in pregnant women with premature rupture membrane (PROM). Methods This study developed CRISPR-GBS assay that combined advantages recombinase polymerase amplification (RPA) CRISPR/Cas12a system detection. The clinical performance was assessed using vaginal cervical swabs were...
The quantitative detection of drug-resistance mutations in Mycobacterium tuberculosis (MTB) is critical for determining the drug resistance status a sample. We developed drop-off droplet digital PCR (ddPCR) assay targeting all major isoniazid (INH)-resistant mutations. ddPCR consisted three reactions: reaction A detects at katG S315; B inhA promoter mutations; and C ahpC All reactions could quantify 1%-50% mutants presence wild-type, ranging from 100 to 50,000 copies/reaction. Clinical...