A5100655644- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Amino Acid Enzymes and Metabolism
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Tryptophan and brain disorders
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Mycobacterium research and diagnosis
- Lung Cancer Treatments and Mutations
- Genetics and Neurodevelopmental Disorders
- Stress Responses and Cortisol
- Ferroptosis and cancer prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer Mechanisms and Therapy
- Histone Deacetylase Inhibitors Research
- interferon and immune responses
- Angiogenesis and VEGF in Cancer
- Breast Cancer Treatment Studies
- Lung Cancer Diagnosis and Treatment
Wenzhou Medical University
2024-2025
Nanjing University of Chinese Medicine
2021-2024
Jiangsu Province Hospital
2022-2024
Columbia University Irving Medical Center
2024
Zhejiang Ocean University
2024
First Affiliated Hospital of Bengbu Medical College
2011-2024
Vanderbilt University Medical Center
2015-2023
Xuzhou Medical College
2023
Nantong University
2023
Yancheng First People's Hospital
2023
Section:ChooseTop of pageAbstract <<MATERIALS AND METHODSRESULTSDISCUSSIONReferencesCITING ARTICLES
Many tumors increase uptake and dependence on glucose, cystine or glutamine. These basic observations cancer cell metabolism have opened multiple new diagnostic therapeutic avenues in research. Recent studies demonstrated that smoking could induce the expression of xCT (SLC7A11) oral cells, suggesting overexpression may support lung tumor progression. We hypothesized occurs cells to satisfy metabolic requirements for growth survival. Our results 1) was highly expressed at cytoplasmic...
Reduced expression of miR-129 has been reported in multiple tumor cell lines and primary tumors including medulloblastoma, undifferentiated gastric cancers, lung adenocarcinoma, endometrial cancer colorectal carcinoma. There is also recent evidence an antiproliferative activity lines. Still, little known about how regulates proliferation. Here we found that lentiviral-mediated over-expression mouse epithelial cells (E10 cells) results significant G1 phase arrest eventually leads to death....
We previously elucidated the pleotropic role of solute carrier family A1 member 5 (SLC1A5) as primary transporter glutamine (Gln), a modulator cell growth and oxidative stress in non-small lung cancer (NSCLC). The aim our study was to evaluate SLC1A5 potential new therapeutic target candidate biomarker predictive survival response therapy. targeting examined panel NSCLC human bronchial lines by RNA interference small molecular inhibitor, gamma-l-glutamyl-p-nitroanilide (GPNA). effects on...
The resistance to chemotherapeutic drugs is a critical feature of breast cancer recurrence and metastasis. Long non-coding RNAs (LncRNAs) serve key roles in tumor drug resistance. LncRNA-HOX transcript antisense RNA (HOTAIR) has been reported be overexpressed certain types may closely associated with current study aimed investigate the role lncRNA-HOTAIR regulation doxorubicin (DOX). A cell line (MCF-7) DOX-resistant (DOXR-MCF-7) were utilized study. DOXR-MCF-7 cells transfected small...
Significance Altered expression of RNA binding proteins might contribute to cancer development. This study reveals the functional implications and clinical relevance FXR1, an protein, in non-small cell lung (NSCLC). Our results demonstrate that FXR1 promotes tumor progression by regulating two other oncogenes within same chromosome 3q amplicon. To drive progression, forms a new complex with protein kinase C, iota, posttranscriptionally stabilizes epithelial transforming 2. We show increased...
Abstract This study was implemented to figure out whether lnc RNA HOTAIR /miR‐17‐5p/ PTEN axis played a role that opposite Shenqifuzheng ( SQFZ ) injection in regulating the chemosensitivity of gastric cancer cells. The tissues were gathered and four cell lines prepared, including BGC ‐823, MGC ‐803, SGC ‐7901, MKN 28. Moreover, cisplatin, adriamycin, mitomycin, 5‐fluoroura managed as chemo‐therapeutics, prepared Chinese medicine. Striking distinctions , miR‐17‐5p, expressions observed...
Osteopontin (OPN) is widely overexpressed in various cancers, including gliomas, and plays an important role tumorigenesis. However, the expression pattern functions of OPN splice variants expressed gliomas remain unclear. The aims our current study were to examine gliomas. In present study, mRNA levels are markedly increased tissues, all also found U251 U87 cells. Furthermore, knock-down regain function experiments designed explore Lentiviral vectors small interference RNA (siRNA) targeting...
Background/Aims: Colorectal cancer (CRC) is one of the leading causes cancer-related deaths globally, with many oncogenes and tumor suppressors involved. The miRNAs are small non-coding RNAs known to play a vital role in pathogenesis CRC. miR-423-3p was reported act as an oncogene; however, its CRC growth remains unknown. Methods: qPCR assay used detect expression specimens. Cell proliferation transwell were conducted evaluate cell migration. Luciferase reporter identify target gene...
Rationale: We have a limited understanding of the molecular underpinnings early adenocarcinoma (ADC) progression. hypothesized that behavior ADC can be predicted based on genomic determinants.Objectives: To identify alterations associated with resected indolent and aggressive lung ADCs.Methods: DNA was extracted from 21 ADCs in situ (AISs), 27 minimally invasive (MIAs), 54 fully ADCs. This subjected to deep next-generation sequencing tested against custom panel 347 cancer genes.Measurements...
Abstract The current investigation explored the synthetic contribution of lncRNA H19, miR‐130a‐3p, and miR‐17‐5p to radio‐resistance chemo‐sensitivity cardiac cancer cells. Totally 284 human tissues were gathered, they have been pathologically diagnosed. cells isolated with utilization mechanic method. Moreover, cisplatin, adriamycin, mitomycin, 5‐fluorouracil designated as chemotherapies, single‐dose X‐rays managed radiotherapy for We also performed luciferase reporter gene assay verify...
Colorectal cancer (CRC) is one of the most common malignant tumors with a poor prognosis. At present, pathogenesis not completely clear. Therefore, finding reliable prognostic indicators for CRC important clinical significance. In this study, bioinformatics methods were used to screen immune-related lncRNAs CRC, and risk scoring model based on signatures constructed provide basis evaluation immunotherapy patients.The information RNA-seq data patients obtained from The Cancer Genome Atlas...
The molecular determinants of lung cancer risk remain largely unknown. Airway epithelial cells are prone to assault by factors and considered be the primary cell type involved in field cancerization. To investigate risk-associated changes bronchial epithelium proteome that may offer new insights into pathogenesis cancer, proteins were identified airway brushing specimens from risk-stratified individuals shotgun proteomics. Differential expression selected was validated parallel reaction...
LncRNA NR2F2-AS1 has been characterized as an oncogenic lncRNA in non-small cell lung cancer. This study aims to explore the role of colorectal cancer (CRC).All CRC patients (n=60, 35 males and 25 females, 40 68 years old) this were enrolled Changzhou No.2 People's Hospital Nanjing Medical University during time period between July 2011 December 2013. Tumor samples, cells, vectors, transient transfections, RT-qPCR, western-blotting, well measurements cycle, apoptosis proliferation assay...
Long non-coding RNA (lncRNA) PCED1B-AS1 was shown to play essential roles in human cancers, while its function colorectal adenocarcinoma remains unclear. This study carried out investigate the of regulating microRNA(miR)-633/HOXA9 axis adenocarcinoma. The expression PCED1B-AS1, miR-633 and HOXA9 measured by quantitative real-time PCR (qRT-PCR) or Western blot analysis. Cell behaviors cell lines were assessed CCK-8, EdU, Transwell flow cytometry assays. interaction among determined luciferase...
Adipocytes, especially adipocytes within tumor tissue known as cancer-associated adipocytes, have been increasingly recognized for their pivotal role in the microenvironment of gastric cancer (GC). Their influence on progression and patient prognosis has sparked significant interest recent research. The main objectives this study were to investigate adipocyte infiltration, assess its correlation with clinical pathological features, develop a prognostic prediction model based independent...
Abstract Triple negative breast cancers (TNBC) are aggressive tumors, with high rates of metastatic spread and targeted therapies critically needed. We aimed to assess the prognostic predictive value a 3q 19-gene signature identified previously from lung cancer in collection 4,801 tumor gene expression data. The had strong association features aggressiveness such as grade, hormone receptor negativity, presence basal-like or TNBC phenotype reduced distant metastasis free survival. was...
The inhibitory role of microRNA-29a (miR-29a) has been assessed in breast cancer cells. Herein, we analyze the underlying mechanisms its cell cycle progression cells.We applied real-time polymerase chain reaction (PCR) to detect expression miR-29 lines. Then one lines, MDA-MB-453, was transfected with mimics miR-29a. analyzed by fluorescence-activated sorting after staining cells propidium iodide. Real-time PCR, luciferase assay and western blot were used together verify regulation predicted...
The present study aimed to investigate the effects and mechanisms of STAM binding protein-like 1 (STAMBPL1) knockdown in suppression gastric cancer activities. Pathological data STAMBPL1 protein expression were analysed 36 patients with cancer, including 24 stage I-II 12 III-IV patients, by haematoxylin eosin staining immunohistochemistry. In vitro cell experiments performed measure AGS proliferation, apoptosis, invasion migration MTT, Celigo count, flow cytometry, Transwell wound healing...