A5101870234- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gut microbiota and health
- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Neonatal Respiratory Health Research
- Antioxidant Activity and Oxidative Stress
- Amino Acid Enzymes and Metabolism
- RNA modifications and cancer
- Pediatric health and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- Respiratory Support and Mechanisms
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Cancer, Hypoxia, and Metabolism
- Alcohol Consumption and Health Effects
- Vitamin K Research Studies
- Long-Term Effects of COVID-19
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Sphingolipid Metabolism and Signaling
- Sulfur Compounds in Biology
- Vitamin C and Antioxidants Research
- Inflammation biomarkers and pathways
- Probiotics and Fermented Foods
Pennsylvania State University
2024
Georgia State University
2018-2024
Vanderbilt University
2015-2018
Many tumors increase uptake and dependence on glucose, cystine or glutamine. These basic observations cancer cell metabolism have opened multiple new diagnostic therapeutic avenues in research. Recent studies demonstrated that smoking could induce the expression of xCT (SLC7A11) oral cells, suggesting overexpression may support lung tumor progression. We hypothesized occurs cells to satisfy metabolic requirements for growth survival. Our results 1) was highly expressed at cytoplasmic...
Significance Altered expression of RNA binding proteins might contribute to cancer development. This study reveals the functional implications and clinical relevance FXR1, an protein, in non-small cell lung (NSCLC). Our results demonstrate that FXR1 promotes tumor progression by regulating two other oncogenes within same chromosome 3q amplicon. To drive progression, forms a new complex with protein kinase C, iota, posttranscriptionally stabilizes epithelial transforming 2. We show increased...
Although a few studies show that the use of electronic nicotine delivery systems (ENDS) may ameliorate objective and subjective outcomes in COPD smokers who switched to cigarettes, it is unclear whether e-cigarette exposure alters lung pathological features inflammatory response COPD. Here, we employed βENaC-overexpressing mice bearing COPD-like pulmonary abnormality, exposed them ENDS. We found ENDS aggravated airspace enlargement mucus production mice, which was associated with increased...
Coronavirus disease 2019 (COVID-19) has so far infected hundreds of million individuals, with several deaths worldwide. The lack understanding the pathophysiology and host's immune response resulted in this rapid spread on a global scale. In respect, we employed UPLC-MS to compare metabolites serum from COVID-19-positive patients COVID-19-recovered subjects determine metabolic changes responsible for an infection. Our investigations revealed significant increase levels phospholipids...
Chronic lung diseases, such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive disease (COPD), are major leading causes of death worldwide generally associated with poor prognoses. The heterogeneous distribution collagen, mainly type I collagen excessive deposition, plays a pivotal role in the progressive remodeling parenchyma to exertional dyspnea for both IPF COPD. To address pressing need noninvasive early diagnosis drug treatment monitoring fibrosis, we report development...
Abstract Background Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in United States with no effective treatment. The current diagnostic method, spirometry, does not accurately reflect severity COPD status. Therefore, there a pressing unmet medical need to develop noninvasive methods and reliable biomarkers detect early stages COPD. Lipids are fundamental components cell membranes, dysregulation lipids was proven be associated Lipidomics comprehensive...
Dysmorphic pulmonary vascular growth and abnormal endothelial cell (EC) proliferation are paradoxically observed in premature infants with bronchopulmonary dysplasia (BPD), despite pruning. The pentose phosphate pathway (PPP), a metabolic parallel to glycolysis, generates NADPH as reducing equivalent ribose 5-phosphate for nucleotide synthesis. It is unknown whether hyperoxia, known mediator of BPD rodent models, alters glycolysis the PPP lung ECs. We hypothesized that hyperoxia increases...
More than half of the states in U.S. report that over 30% adults are obese. Obesity increases risk many chronic diseases, including type 2 diabetes, hypertension, cardiovascular disease, and can even reduce one’s lifespan. Similarly, prevalence diabetes follows a comparable trend. As result, researchers striving to find solutions obesity rates, with particular focus on gut health, which has been previously linked both diabetes. Recent studies suggest Akkermansia muciniphila(AKK) may have...
Treatments with supplemental oxygen in premature infants can impair lung development, leading to bronchopulmonary dysplasia (BPD). Although a stage-specific alteration of lipidome occurs during postnatal whether neonatal hyperoxia, known mediator BPD rodent models, changes lipid profiles mouse lungs is still be elucidated. To answer this question, newborn mice were exposed hyperoxia for 3 days and allowed recover normoxia until day (pnd) 7 pnd14, time-points spanning the peak stage...
Metabolites are essential intermediate products in metabolism, and metabolism dysregulation indicates different types of diseases. Previous studies have shown that cigarette smoke dysregulated metabolites; however, limited information is available with electronic (e-cig) vaping. We hypothesized e-cig vaping smoking alters systemic metabolites, we propose to understand the specific metabolic signature between users smokers. Plasma from non-smoker controls, smokers, was collected, metabolites...
Osteoporosis is a degenerative bone disease affecting millions, mostly the aging population. Osteoblasts and osteoclasts maintain balance in resorption formation. Changes occurring differentiation, proliferation activity of these two cell types result lower mass microarchitecture deterioration, leading to compromised strength. Chronic inflammation oxidative stress disrupt between osteoblasts osteoclasts. Tocotrienols, vitamin E isoforms with an unsaturated hydrophobic tridecyl chain, reduce...
Introduction Chronic obstructive pulmonary disease (COPD) is currently listed as the 3 rd leading cause of death in United States. Accumulating data shows association between COPD occurrence and usage electronic nicotine delivery systems (ENDS) patients. However, underlying pathogenesis mechanisms have not been fully understood. Methods In current study, bENaC-overexpressing mice (bENaC mice) were subjected to whole-body ENDS exposure. related features including emphysema, mucus...
Chronic obstructive pulmonary disease (COPD) remains a leading cause of death and treatment options for this condition remain scant. This study aims to examine the ability γ-tocotrienol mitigate progression in an animal model COPD induced by e-cigarettes. We hypothesize that will attenuate inflammation subsequently slow e-cigarette COPD. Scnn1b-Tg + mice (n = 10/group), were exposed vapor twice daily 10 days acute eight weeks chronic with or without at dose 100 mg/kg/day. Following...
Xanthorrhizol, a sesquiterpene, and d-δ-tocotrienol, vitamin E molecule, each suppresses the proliferation of number tumor cells. This study aims to examine potentially synergistic effect xanthorrhizol d-δ-tocotrienol in Murine B16 melanoma human DU145 prostate carcinoma cells were incubated for 48 h (B16) or 72 (DU145) with before cell populations determined by CellTiter 96â Aqueous One Solution. Cells agents 24 hours stained propidium iodide analyzed cycle using flow cytometry MultiCycle...