A5009885491- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Cancer Research and Treatments
- Medical Imaging and Pathology Studies
- Melanoma and MAPK Pathways
- Natural Antidiabetic Agents Studies
- Liver Disease and Transplantation
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Fibroblast Growth Factor Research
- Phytochemical compounds biological activities
- Hedgehog Signaling Pathway Studies
- Phytochemicals and Antioxidant Activities
- Molecular Biology Techniques and Applications
- interferon and immune responses
- Antifungal resistance and susceptibility
- Mast cells and histamine
- Inhalation and Respiratory Drug Delivery
- Diverse Scientific Research Studies
- Parasitic Infections and Diagnostics
- vaccines and immunoinformatics approaches
- Sirtuins and Resveratrol in Medicine
Memorial Sloan Kettering Cancer Center
2023-2025
Georgia State University
2018-2023
Kettering University
2023
Sawai ManSingh Medical College and Hospital
1991-2021
Panjab University
2008
Abstract Early diagnosis and noninvasive detection of liver fibrosis its heterogeneity remain as major unmet medical needs for stopping further disease progression toward severe clinical consequences. Here we report a collagen type I targeting protein-based contrast agent (ProCA32.collagen1) with strong affinity. ProCA32.collagen1 possesses high relaxivities per particle (r 1 r 2 ) at both 1.4 7.0 T, which enables the robust early-stage (Ishak stage 3 6) nonalcoholic steatohepatitis 6 or A...
Fibrotic tumor stroma plays an important role in facilitating triple-negative breast cancer (TNBC) progression and chemotherapeutic resistance. We previously reported a rationally designed protein (ProAgio) that targets integrin αvβ3 at novel site. ProAgio induces apoptosis via the integrin. Cancer-associated fibroblasts (CAFs) angiogenic endothelial cells (aECs) TNBC express high levels of αvβ3. effectively CAFs aECs. The depletion by reduces intratumoral collagen decreases growth factors...
Abstract BRAFV600E mutations occur in 46% of melanomas and drive high levels ERK activity ERK-dependent proliferation. However, is insufficient to melanoma genetically engineered mouse models, 82% human benign nevi harbor mutations. We found that inhibited mesenchymal migration by causing feedback inhibition RAC1 activity. pathway induced activation restored invasion. In cells with BRAFV600E, mutant or PTEN inactivation cell motility. Together, these lesions occurred 26% Thus, although...
Insulin resistance is a condition associated with obesity, type 2 diabetes(T2D), hyperinsulinemia, hyperglycemia and defined by reduced sensitivity to insulin signaling. Molecular causes early signaling events underlying are not well understood. Here we show that activation of PI3K/AKT/mTOR in target tissues, mTORC1 induction PTEN translation, negative regulator PI3K We hypothesized due dependent prevents further increases In diet induced animal model obesity resistance, levels increased...
Rationale: Fibrosis is a pathologic condition of abnormal accumulation collagen fibrils. Collagen major extracellular matrix (ECM) protein synthesized and secreted by myofibroblasts, composing mainly (Gly-X-Y)n triplet repeats with >30% Gly residue. During fibrosis progression, myofibroblasts must upregulate glycine metabolism to meet the high demands amino acids for synthesis. Method: Expression PKM2 in was analyzed cultured fibroblasts disease tissues. Functional roles activator...
Chronic lung diseases, such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive disease (COPD), are major leading causes of death worldwide generally associated with poor prognoses. The heterogeneous distribution collagen, mainly type I collagen excessive deposition, plays a pivotal role in the progressive remodeling parenchyma to exertional dyspnea for both IPF COPD. To address pressing need noninvasive early diagnosis drug treatment monitoring fibrosis, we report development...
Background & AimsPancreatic ductal adenocarcinoma (PDAC) is resistant to most therapeutics owing dense fibrotic stroma orchestrated by cancer-associated pancreatic stellate cells (CAPaSC). CAPaSC also support cancer cell growth, metastasis, and resistance apoptosis. Currently, there no effective therapy for PDAC that specifically targets CAPaSC. We previously reported a rationally designed protein, ProAgio, integrin αvβ3 at novel site induces apoptosis in αvβ3-expressing cells. Because both...
Abstract The majority of human breast cancers are dependent on hormone-stimulated estrogen receptor alpha (ER) and sensitive to its inhibition. Treatment resistance arises in most advanced due genetic alterations that promote ligand independent activation ER itself or target genes. Whereas re-targeting the binding domain (LBD) with newer antagonists can work some cases, these drugs largely ineffective many backgrounds including fusions lose LBD hyperactivate targets. By identifying mechanism...
Abstract Chronic Liver Diseases (CLD) are characterized by abnormal accumulation of collagen fibrils, neo-angiogenesis, and sinusoidal remodeling. Collagen deposition along with intrahepatic angiogenesis remodeling alters sinusoid structure resulting in portal hypertension, liver failure, other complications. Efforts were made to develop treatments for CLDs. However, the success such is limited unpredictable. We report a strategy CLD treatment induction integrin α v β 3 mediated cell...
Despite reports of successful clinical cases, many tumors appear to resist infection by oncolytic viruses (OVs). To circumvent this problem, an armed vesicular stomatitis virus was constructed inserting a transgene express Smac/DIABLO during (VSV-S). Endogenous Smac in HeLa cells diminished wtVSV infection, whereas the level enhanced VSV-S infection. Apoptosis readily induced VSV-S, but not wtVSV, More importantly, tumor volume reduced larger extent when xenografts 4T1 BALB/c mice and...
Type 2 Diabetes (T2D) is a condition that often associated with obesity and defined by reduced sensitivity of PI3K signaling to insulin (insulin resistance), hyperinsulinemia hyperglycemia. Molecular causes early events underlying resistance are not well understood. Insulin activation mTOR dependent induction PTEN translation, negative regulator signaling. We speculated due protein prevent further increases in Here we show diet induced model resistance, levels increased fat, muscle liver...
Aberrant expression of P68 RNA helicase (p68), a prototypical member the DEAD box family helicases, contributes to tumor development and progression. tyrosine phosphorylation induced by PDGF signaling facilitates cancer metastasis promoting EMT. In this report, we show that p68 promotes breast cell EMT migration upregulation receptor β (PDGFR-β). Knockdown in MDA-MB-231 BT549 cells significantly decreases PDGFR-β both mRNA protein levels. response PDGF-BB stimulation via PDGFR-β, suggesting...
Abstract The PI3K pathway is a key regulator of metabolism, cell proliferation and migration some its components (e.g. PIK3CA, HER2 PTEN) are frequently altered in cancer by genetic events that deregulate output. However, inhibitors the have only modest antitumor effects and, instances, resulted “tumor flares” patients upon cessation therapy. Low efficacy has been attributed to toxicity adaptive resistance due relief feedback. Inhibition associated with increased receptor expression...
Abstract BRAF V600E mutation occurs in 46% of melanomas and drives high levels ERK activity ERK-dependent proliferation. However, is insufficient to drive melanoma GEMM models, 82% human benign nevi harbor mutations. We show here that inhibits mesenchymal migration by causing feedback inhibition RAC1 activity. pathway induces activation restores invasion. In cells with , mutant RAC1, overexpression PREX1, PREX2, or PTEN inactivation restore cell motility. Together, these lesions occur 48%...
Summary A middle-aged female with an atrial septal defect (secundum type) presented a primary pulmonary amoebic abscess. She was successfully treated antiamoebic therapy. One year later she similar lung abscess which again responded to antiamboebic treatment. Attention is drawn the fact that patient left right shunt can present recurrent rare parasitic infection of lung.
Lantana camara L. is one of the ten most obnoxious weeds world and it has encroached upon a large land area in Asia as well other parts world. It imposed great threat to grazing animals overall ecology.
Abstract Background: TNBC metastasis is responsible for a majority of the mortalities associated with breast cancer across globe. Cancers metastasize to various distant organs such as lungs, liver, and bones, which accounts low 5-year survival rate. Lung offers most favorable environment is, therefore, common metastatic site in patients. Currently, there are no effective targeted therapies hence dire clinical need establish treatment this disease. It noteworthy that tumor growth supported by...
Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with five-year survival rate of just 9% after diagnosis. Despite large efforts in developing treatments, the outcome therapies for patient only improves marginally. Dense fibrotic stroma and ECM orchestrated by cancer-associated pancreatic stellate cells (CAPaSC) considered to be one major contributors resistance anti-tumor this disease. The presence dense collagen fibrils forms physical block drug delivery...
Abstract Background: Pancreatic ductal adenocarcinoma (PDA) is the most lethal form of cancer owing to its insensitivity many chemotherapeutic drugs. Gemcitabine remains a cornerstone PDA treatment despite suboptimal efficacy in clinics. One major mechanism by which becomes resistant gemcitabine conversion inactive derivative, dFdU upregulation enzyme, cytidine deaminase (Cda) cells. Activated pancreatic stellate cells (PSC) are source IGF1 tumor microenvironment, may be responsible for an...
Background: Pancreatic ductal adenocarcinoma (PDA) is the most lethal form of cancer owing to its insensitivity many chemotherapeutic drugs. Gemcitabine remains a cornerstone PDA treatment despite suboptimal efficacy in clinics. One major mechanism by which becomes resistant gemcitabine conversion inactive derivative, dFdU upregulation enzyme, cytidine deaminase (Cda) cells. Activated pancreatic stellate cells (PSC) are source IGF1 tumor microenvironment, may be responsible for an increase...
Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer with five-year survival rate of just 9% after diagnosis. Despite large efforts in developing treatments, the outcome therapies for patient only improves marginally. Dense fibrotic stroma and ECM orchestrated by cancer-associated pancreatic stellate cells (CAPaSC) considered to be one major contributors resistance anti-tumor this disease. The presence dense collagen fibrils forms physical block drug delivery completely...