A5019722864- Quantum Chromodynamics and Particle Interactions
- Particle physics theoretical and experimental studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- High-Energy Particle Collisions Research
- Black Holes and Theoretical Physics
- MRI in cancer diagnosis
- Atomic and Subatomic Physics Research
- Functional Brain Connectivity Studies
- Medical Imaging Techniques and Applications
- Reproductive System and Pregnancy
- Olfactory and Sensory Function Studies
- Neural dynamics and brain function
- Particle Accelerators and Free-Electron Lasers
- Dark Matter and Cosmic Phenomena
- Fetal and Pediatric Neurological Disorders
- Chemokine receptors and signaling
- Neutrino Physics Research
- Cerebral Palsy and Movement Disorders
- Lanthanide and Transition Metal Complexes
- Recommender Systems and Techniques
- Dementia and Cognitive Impairment Research
- Collaborative and Sustainable Housing Initiatives
- Pharmacological Effects of Medicinal Plants
- Grey System Theory Applications
University of Chinese Academy of Sciences
2024-2025
Beijing Institute of Technology
2024-2025
Anhui University
2025
Emory University
2014-2024
Chinese Academy of Sciences
2008-2024
Wuhan Institute of Physics and Mathematics
2008-2024
State Key Laboratory of Magnetism
2024
Daqing Oilfield General Hospital
2024
Institute of Physics
2024
Imaging Center
2014-2023
Chemokine CXCL8 (also known as IL-8) has been identified a potential regulator of endometrial stromal cells (ESCs), but it is unclear how regulates the survival ESCs in pathogenesis endometriosis.We assessed secretion by enzyme-linked immunosorbent assays and expression its receptors, CXCR1 CXCR2, in-cell Western assay immunohistochemistry. The effects on activation or various cell mediators were also investigated assay. proliferation, growth apoptosis vitro BrdU assays, counts annexin V...
With the rapid development of computer technology Image processing is playing an increasingly important role in various fields. However, traditional edge detection algorithms are difficult to meet needs massive data volumes and demands scenarios with high real-time requirements. Therefore, research topic this paper algorithm based on FPGA. This summarizes existing FPGA, which have been studied by scholars both at home abroad, then implements five operators using Opencv vision library Python....
ABSTRACT With the increased applications of zinc oxide (ZnO) nanoparticles (NPs), toxicity ZnO NPs arouses great concerns from nano community and general public. In this study, we report (30 nm) to rat olfactory system after intranasal instillation revealed by non‐invasive magnetic resonance imaging (MRI). MRI scans were performed on a 4.7‐T scanner at 1, 2, 3 7 days post‐exposure, histological changes epithelium evaluated. The influences chemical component dispersant also investigated....
Chronic lung diseases, such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive disease (COPD), are major leading causes of death worldwide generally associated with poor prognoses. The heterogeneous distribution collagen, mainly type I collagen excessive deposition, plays a pivotal role in the progressive remodeling parenchyma to exertional dyspnea for both IPF COPD. To address pressing need noninvasive early diagnosis drug treatment monitoring fibrosis, we report development...
The nonequilibrium carrier and phonon dynamics in ${\mathrm{Bi}}_{2}{\mathrm{Se}}_{3}$ was studied by a combination of Raman scattering ultrafast optical pump-probe spectroscopy at high pressures up to 31 GPa. Detailed analysis reveals that the pressure dependence relaxation time damping rate ${A}_{1g}^{1}$ mode exhibit an anomaly around 3 GPa supporting occurrence electronic topological transition. At higher pressure, transient reflectivity spectra manifest discontinuous changes 11.5, 18.9,...
Summary Understanding how the body is represented in motor cortex key to understanding brain controls movement. The precentral gyrus (PCG) has long been thought contain largely distinct regions for arm, leg and face (represented by “motor homunculus”). However, mounting evidence begun reveal a more intermixed, interrelated broadly tuned map. Here, we revisit homunculus using microelectrode array recordings from 20 arrays that sample PCG across 8 individuals, creating comprehensive map of...
Transgenic Huntington's disease monkey (HD monkey) model provides great opportunity for studying progression that could lead to new insight developing biomarker, early intervention and novel therapeutics. Whole brain white matter integrity of HD-monkeys was examined longitudinally from 6 48 months using diffusion tensor imaging (DTI) tract-based spatial statistics (TBSS). Progressive developmental alterations in HD monkeys were widespread observed not only fiber bundles connecting cortical...
Design a protein-based contrast agent for detecting liver metastases with magnetic resonance imaging.
Amyloid-related imaging abnormalities (ARIA) in magnetic resonance scans have emerged as indicators of potentially serious side effects clinical trials therapeutics for Alzheimer's disease. These anomalies include an edematous type (ARIA-E) that appears hyperintense (bright) regions by T2-weighted MRI, and a characterized the deposition hemosiderin (ARIA-H) elicits hypointense signal, especially T2* susceptibility weighted images. ARIA general has been linked to presence amyloid-β (Aβ)-type...
Purpose To develop fast multi‐slice apparent T 1 ( 1app ) mapping for accurate cerebral blood flow (CBF) quantification with arterial spin labeling (ASL) MRI. Methods Fast was measured using a modified inversion recovery echo planar imaging (EPI) sequence simultaneous application of ASL tagging radiofrequency (RF) and gradient pulses. The measurement compared the single‐slice approach, repeated per slice. CBF assessed in healthy adult Wistar rats (N = 5) acute stroke 24 hours after transient...
Previous Diffusion Tensor Imaging (DTI) studies have demonstrated the temporal evolution of stroke injury in grey matter and white can be characterized by DTI indices. However, it still remains not fully understood how indices are altered progressively during hyperacute (first 6 hours) acute stage (≤ 1 week). In present study, was employed to characterize infarction after insult using a macaque model with permanent ischemic occlusion.Permanent middle cerebral artery (MCA) occlusion induced...
Since zinc oxide (ZnO) nanoparticles (NPs) have been widely applied, the nano community and general public paid great attention to toxicity of ZnO NPs. We detected 20-nm NPs biotoxicity following nasal exposure utilizing non-invasive real-time magnetic resonance imaging (MRI) technique. MR images were scanned in rat olfactory epithelium (OE) bulb (OB) on a 4.7 T scanner treatment (as early as 1 day up 21 days after), histological changes evaluated. The influence size chemical components was...
In comparison with conventional diffusion tensor imaging (DTI) technique, spectrum (DSI) allows for delineating crossing and touching fibers in the brain has been explored clinical preclinical studies. Non-human primates (NHPs) resemble most aspects of human are widely employed various neuroscience researches pharmaceutical development. present study, a parallel imaging-based DSI protocol was implemented vivo fiber tracking macaque monkey brains on 3.0 T scanner. Transcallosal tracts adult...
Abstract A turbo dynamic arterial spin labeling method (Turbo‐DASL) was developed to simultaneously measure cerebral blood flow (CBF) and transit time with high temporal resolution. With Turbo‐DASL, images were repeatedly acquired a spiral readout after small‐angle excitations during pseudocontinuous control periods. Turbo‐DASL experiments at 9.4 T without diffusion gradients performed on rats anesthetized isoflurane or α‐chloralose. We determined times from carotid arteries cortical vessels...
Background: The oxygen extraction fraction (OEF) indicates the brain’s consumption and can be estimated by using quantitative susceptibility mapping (QSM) MRI technique. Recent studies have suggested that OEF alteration following stroke is associated with viability of at-risk tissue. In present study, temporal evolution in monkey brain during acute was investigated QSM. Methods: Ischemic induced adult rhesus monkeys (n = 8) permanent middle cerebral artery occlusion (pMCAO) an interventional...
Interhemispheric communication plays a critical role to ensure normal brain functions in cognition and behavior. Since non-human primate (NHP) brains resemble most aspects of the human brain, thorough knowledge interhemispheric cortical connectivity changes NHP throughout developmental aging periods may provide valuable insights for translational clinical research. In this study, formalin-fixed rhesus monkey aged from 1 24 years were utilized examine transcallosal using diffusion spectrum...
T2*-weighted imaging (T2*WI) and quantitative T2* mapping with conventional gradient-echo acquisition are often hindered by severe signal loss induced macroscopic field inhomogeneity. Various z-shimming approaches have been developed for T2*WI/T2* in which the effects of inhomogeneity suppressed while sensitivity T2*-related intensity to alterations microscopic susceptibility is maintained. However, this done at cost significantly increased time. In work, a fast method compensation was...
Abstract To investigate the effects of neonatal hippocampal lesions on microstructural integrity corpus callosum (CC) in adulthood, macaque monkeys ( n = 5) with bilateral neurotoxic lesion (Neo‐Hibo) and sham‐operated controls (Neo‐C, were scanned using magnetic resonance diffusion tensor imaging (DTI) technique at 8–10 years old. CC was segmented into seven regionsgrouped anterior (rostrum, genu, rostral body midbody) posterior (posterior midbody, isthmus splenium) for data analysis....
Purpose To characterize and minimize the magnetization transfer (MT) effect in MR fingerprinting (MRF) relaxation measurements with a 2‐pool (2P) MT model of multiple tissue types. Theory Methods Semisolid MRF was modeled using 2P Bloch‐McConnell equations. The combinations parameters tissues (white [WM] gray matter [GM]) were used to build dictionary. Both 1‐pool (1P) models simulated dependence on MT. Relaxations measured spin‐echo saturation‐recovery (SR) or inversion‐recovery...
Abstract Noninvasive detection of early-stage liver metastases from different primary cancers is a pressing unmet medical need. The lack both molecular biomarkers and the sensitive imaging methodology makes challenging. In this study, we observed elevated expression chemokine receptor 4 (CXCR4) in uveal melanoma (UM) patient tissues, high CXCR4 UM murine models, regardless levels tumors. Based on these findings, identified as an biomarker exploited CXCR4-targeted MRI contrast agent...
Investigation of stroke lesion has mostly focused on grey matter (GM) in previous studies and white (WM) degeneration during acute is understudied. In the present study, monkeys were utilized to investigate alterations GM WM brain following ischemic occlusion using diffusion tensor imaging (DTI).