A5053284254- RNA Research and Splicing
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- EEG and Brain-Computer Interfaces
- Cancer Research and Treatments
- Muscle activation and electromyography studies
- CAR-T cell therapy research
- Advanced biosensing and bioanalysis techniques
- Virus-based gene therapy research
- interferon and immune responses
- RNA Interference and Gene Delivery
- Neural dynamics and brain function
Poseida Therapeutics (United States)
2024
The lack of accessible noninvasive tools to examine the molecular alterations occurring in brain limits our understanding causes and progression Alzheimer's disease (AD), as well identification effective therapeutic strategies. Here, we conducted a comprehensive profiling circulating, cell-free messenger RNA (cf-mRNA) plasma 126 patients with AD 116 healthy controls similar age. We identified 2591 dysregulated genes cf-mRNA AD, which are enriched biological processes known be associated AD....
Abstract Circulating cell-free mRNA (cf-mRNA) holds great promise as a non-invasive diagnostic biomarker. However, cf-mRNA composition and its potential clinical applications remain largely unexplored. Here we show, using Next Generation Sequencing-based profiling, that is enriched in transcripts derived from the bone marrow compared to circulating cells. Further, longitudinal studies involving ablation followed by hematopoietic stem cell transplantation multiple myeloma acute myeloid...
Summary Understanding how the body is represented in motor cortex key to understanding brain controls movement. The precentral gyrus (PCG) has long been thought contain largely distinct regions for arm, leg and face (represented by “motor homunculus”). However, mounting evidence begun reveal a more intermixed, interrelated broadly tuned map. Here, we revisit homunculus using microelectrode array recordings from 20 arrays that sample PCG across 8 individuals, creating comprehensive map of...
Inflammatory and immune responses are essential dynamic biological processes that protect the body against acute chronic adverse stimuli. While conventional protein markers have been used to evaluate systemic inflammatory response, immunological response stimulation is complex involves modulation of a large set genes interacting signalling pathways innate adaptive systems. There need for non-invasive tool can comprehensively monitor molecular dysregulations associated with in circulation...
<h3>Background</h3> Tumor heterogeneity and scarcity of specific antigens present significant challenges for the efficacy CAR-T technology in solid tumors. One potential solution is to generate engineered T cells that can recognize multiple tumor-specificities using both CARs either abTCRs or gdTCRs (CAR+TCR). Unlike CARs, TCRs detect tumor-specific from intracellular proteins stressed cellular states, greatly expanding range antigens. Moreover, concurrent targeting a third tumor antigen via...
Abstract Circulating cell free mRNA (cf-mRNA) holds great promise as a non-invasive diagnostic biomarker. However, the biological origin of cf-mRNA is still not well understood, limiting clinical applications this technology. Here, we use bone marrow (BM) and pharmacologic manipulation its resident cells window to study cf-mRNA. Using NGS-based profiling, show that enriched in transcripts derived from BM compared circulating cells. Further, ablation experiments followed by hematopoietic stem...
ABSTRACT Inflammatory and immune responses are essential dynamic biological processes that protect the body against acute chronic adverse stimuli. While conventional protein markers have been used to evaluate systemic inflammatory response, immunological response stimulation is complex involves modulation of a large set genes interacting signaling pathways innate adaptive systems. Therefore, there need for non-invasive tool can comprehensively monitor molecular dysregulations associated with...