A5070322290- Muscle activation and electromyography studies
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Motor Control and Adaptation
- Neural dynamics and brain function
- Tactile and Sensory Interactions
- Transcranial Magnetic Stimulation Studies
- Pain Management and Treatment
- Laser Applications in Dentistry and Medicine
- Neuroscience, Education and Cognitive Function
- Neural and Behavioral Psychology Studies
- Advanced Memory and Neural Computing
- Hand Gesture Recognition Systems
- Gaze Tracking and Assistive Technology
University of Chicago
2018-2024
University of Illinois Chicago
2024
National Research University Higher School of Economics
2015-2020
Sensory feedback improves dexterous use of a bionic arm, and sensory signals that mimic natural ones are more intuitive useful.
Objective. Hand function can be restored in upper-limb amputees by equipping them with anthropomorphic prostheses controlled signals from residual muscles. The dexterity of these bionic hands is severely limited large part the absence tactile feedback about interactions objects. We propose that, to extent that artificial touch mimics its natural counterpart, sensory will more easily integrated into motor plan for object manipulation. Approach. describe an approach convey through electrical...
Manual interactions with objects are supported by tactile signals from the hand. This feedback can be restored in brain-controlled bionic hands via intracortical microstimulation (ICMS) of somatosensory cortex (S1). In ICMS-based feedback, contact force signaled modulating stimulation intensity based on output sensors hand, which turn modulates perceived magnitude sensation. present study, we gauged dynamic range and precision three human participants implanted arrays microelectrodes S1. To...
Abstract The primary motor (M1) and somatosensory (S1) cortices play critical roles in control but the signaling between these structures is poorly understood. To fill this gap, we recorded – three participants an ongoing human clinical trial (NCT01894802) for people with paralyzed hands responses evoked hand arm representations of M1 during intracortical microstimulation (ICMS) representation S1. We found that ICMS S1 activated some neurons at short, fixed latencies consistent monosynaptic...
Low-dimensional linear dynamics are observed in neuronal population activity primary motor cortex (M1) when monkeys make reaching movements. This population-level behavior is consistent with a role for M1 as an autonomous pattern generator that drives muscles to give rise movement. In the present study, we examine whether similar also during grasping movements, which involve fundamentally different patterns of kinematics and muscle activations. Using variety analytical approaches, show does...
When we interact with objects, rely on signals from the hand that convey information about object and our interaction it. A basic feature of these interactions, locations contacts between object, is often only available via sense touch. Information contact a brain-controlled bionic an can be signaled intracortical microstimulation (ICMS) somatosensory cortex (S1), which evokes touch sensations are localized to specific patch skin. To provide intuitive location information, tactile sensors...
Abstract Intracortical microstimulation (ICMS) is a method for restoring sensation to people with paralysis as part of bidirectional brain-computer interface restore upper limb function. Evoking tactile sensations the hand through ICMS requires precise targeting implanted electrodes. Here we describe presurgical imaging procedures used generate functional maps area somatosensory cortex and subsequent planning that guided implantation intracortical microelectrode arrays. In five participants...
Objective. The hand—a complex effector comprising dozens of degrees freedom movement—endows us with the ability to flexibly, precisely, and effortlessly interact objects. neural signals associated dexterous hand movements in primary motor cortex (M1) somatosensory (SC) have received comparatively less attention than those proximal upper limb control. Approach. To fill this gap, we trained two monkeys grasp objects varying size shape while tracking their postures recording single-unit...
Tactile feedback from brain-controlled bionic hands can be partially restored via intracortical microstimulation (ICMS) of the primary somatosensory cortex. In ICMS, location percepts depends on electrode's and percept intensity stimulation frequency amplitude. Sensors a hand thus linked to somatotopically appropriate electrodes, contact force each sensor used determine amplitude stimulus. Here we report systematic investigation localization ICMS-evoked in three participants with cervical...
Summary Understanding how the body is represented in motor cortex key to understanding brain controls movement. The precentral gyrus (PCG) has long been thought contain largely distinct regions for arm, leg and face (represented by “motor homunculus”). However, mounting evidence begun reveal a more intermixed, interrelated broadly tuned map. Here, we revisit homunculus using microelectrode array recordings from 20 arrays that sample PCG across 8 individuals, creating comprehensive map of...
Although the first experiments on alpha-neurofeedback date back nearly six decades ago, when Joseph Kamiya reported successful operant conditioning of alpha-rhythm in humans, effectiveness this paradigm various experimental and clinical settings is still a matter debate. Here, we investigated changes EEG patterns during continuously administered neurofeedback P4 alpha activity. Two days training were sufficient for significant increase power to occur. A detailed analysis these showed that...
ABSTRACT Intracortical microstimulation (ICMS) is a method for restoring sensation to people with paralysis as part of bidirectional brain–computer interface (BCI) restore upper limb function. Evoking tactile sensations the hand through ICMS requires precise targeting implanted electrodes. Here we describe presurgical imaging procedures used generate functional maps area somatosensory cortex and subsequent planning that guided implantation intracortical microelectrode arrays. In five...
In recent years, several assistive devices have been proposed to reconstruct arm and hand movements from electromyographic (EMG) activity. Although simple implement potentially useful augment many functions, such myoelectric still need improvement before they become practical. Here we considered the problem of reconstruction handwriting multichannel EMG Previously, linear regression methods (e.g. Wiener filter) utilized for this purpose with some success. To improve accuracy, implemented...
A bstract Motor (M1) and somatosensory (S1) cortex play a critical role in motor control but the nature of signaling between these structures is not known. To fill this gap, we recorded – three human participants whose hands were paralyzed as result spinal cord injury responses evoked hand arm representations primary while delivered ICMS to (S1). We found that S1 activated some M1 neurons at short, fixed latencies, locked each pulse manner consistent with monosynaptic activation. However,...
A bstract Rotational dynamics are observed in neuronal population activity primary motor cortex (M1) when monkeys make reaching movements. This population-level behavior is consistent with a role for M1 as an autonomous pattern generator that drives muscles to produce movement. Here, we show does not exhibit smooth during grasping movements, suggesting more input-driven circuit.
SUMMARY In the United States, over 1.5 million people live with lower-limb amputation. Existing prosthetic limbs do not restore somatosensory feedback from limb, resulting in functional impairments including balance deficits and an increased risk of falls. Further, these prostheses alleviate severe phantom limb pain that often follows Leveraging clinically available spinal cord stimulation electrodes, we designed a system restores somatosensation missing thereby improving gait reducing pain....
A bstract Grasping, a seemingly simple manual behavior, requires the coordinated control of dozens joints, guided by sensory signals from muscles, tendons, and skin. As motor cortex controls finger movement exerted forces, somatosensory must process barrage proprioceptive tactile that convey details about object’s shape, its local features (e.g., edges curvature), forces applied to it. In present study, we aimed understand transformation in these sensorimotor at time contact with an object....
The hand, a complex effector comprising dozens of degrees freedom movement, endows us with the ability to flexibly, precisely, and effortlessly interact objects. neural signals associated dexterous hand movements in primary motor cortex (M1) somatosensory (SC) have received comparatively less attention than those that are proximal limb control. To fill this gap, we trained three monkeys grasp objects varying size, shape orientation while tracking their postures recording single-unit activity...