A5024911410- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Muscle activation and electromyography studies
- Transcranial Magnetic Stimulation Studies
- Neural dynamics and brain function
- Pain Management and Treatment
- Spinal Cord Injury Research
- Motor Control and Adaptation
- Stroke Rehabilitation and Recovery
- Neurological disorders and treatments
- Advanced Memory and Neural Computing
- Nerve Injury and Rehabilitation
- Gaze Tracking and Assistive Technology
- Advanced Sensor and Energy Harvesting Materials
- Botulinum Toxin and Related Neurological Disorders
- Functional Brain Connectivity Studies
- Prosthetics and Rehabilitation Robotics
- ECG Monitoring and Analysis
- Conducting polymers and applications
- Muscle Physiology and Disorders
- Cerebral Palsy and Movement Disorders
- Tactile and Sensory Interactions
- Robot Manipulation and Learning
- Musculoskeletal pain and rehabilitation
- Nerve injury and regeneration
University of Pittsburgh
2016-2025
Carnegie Mellon University
2013-2025
Neuroscience Institute
2022-2025
Center for the Neural Basis of Cognition
2013-2024
McGowan Institute for Regenerative Medicine
2010-2020
VA Pittsburgh Healthcare System
2011-2020
University of Wisconsin–Madison
2019
Bioengineering (Switzerland)
2019
Karlsruhe Institute of Technology
2019
Defense Advanced Research Projects Agency
2014-2016
We have developed a biomechanical energy harvester that generates electricity during human walking with little extra effort. Unlike conventional human-powered generators use positive muscle work, our technology assists muscles in performing negative analogous to regenerative braking hybrid cars, where normally dissipated drives generator instead. The mounts at the knee and selectively engages power generation end of swing phase, thus assisting deceleration joint. Test subjects one device on...
Scaffolds composed of cell-free extracellular matrix promote de novo formation functional skeletal muscle tissue in sites volumetric loss.
Brain-computer interface (BCI) technology aims to help individuals with disability control assistive devices and reanimate paralyzed limbs. Our study investigated the feasibility of an electrocorticography (ECoG)-based BCI system in individual tetraplegia caused by C4 level spinal cord injury. ECoG signals were recorded a high-density 32-electrode grid over hand arm area left sensorimotor cortex. The participant was able voluntarily activate his cortex using attempted movements, distinct...
Spinal cord injury (SCI) often affects a person's ability to perform critical activities of daily living and can negatively affect his or her quality life. Assistive technology aims bridge this gap in order augment function increase independence. It is involve consumers the design evaluation process as new technologies such brain-computer interfaces (BCIs) are developed. In survey study 57 veterans with SCI participating 2010 National Veterans Wheelchair Games, we found that restoration...
Background Implantable brain–computer interfaces (BCIs), functioning as motor neuroprostheses, have the potential to restore voluntary impulses control digital devices and improve functional independence in patients with severe paralysis due brain, spinal cord, peripheral nerve or muscle dysfunction. However, reports date had limited clinical translation. Methods Two participants amyotrophic lateral sclerosis (ALS) underwent implant a single-arm, open-label, prospective, early feasibility...
Brain-computer interface (BCI) implants have previously required craniotomy to deliver penetrating or surface electrodes the brain. Whether a minimally invasive endovascular technique recording through jugular vein superior sagittal sinus is safe and feasible unknown.
The prevailing dogma in tissue engineering is cell-centric. One shortcoming of this approach the failure to provide implanted cells with a suitable vivo microenvironment that promotes reconstruction. Extracellular matrix (ECM)-based scaffolds three-dimensional can promote constructive and functional remodeling rather than inflammation scarring even absence any cells. objective study was determine ability an ECM-based scaffold facilitate restoration distal gastrocnemius musculotendinous...
Objective. The dorsal root ganglion is an attractive target for implanting neural electrode arrays that restore sensory function or provide therapy via stimulation. However, penetrating microelectrodes designed these applications are small and deliver low currents. For long-term performance of microstimulation devices, novel coating materials needed in part to decrease impedance values at the electrode-tissue interface increase charge storage capacity. Approach. Conductive polymer...
A polycaprolactone conduit containing growth factor–encapsulated microspheres repairs 5-cm median nerve defects in rhesus macaques.
Recent advancement in electrocorticography (ECoG)-based brain-computer interface technology has sparked a new interest providing somatosensory feedback using ECoG electrodes, i.e., cortical surface electrodes. We conducted 28-day study of stimulation an individual with arm paralysis due to brachial plexus injury examine the sensation produced by electrical cortex. A high-density grid was implanted over and motor cortices. Stimulation through electrodes cortex successfully elicited hand...
Abstract Paralysis of the muscles controlling hand dramatically limits quality life for individuals living with spinal cord injury (SCI). Here, a non-invasive neural interface, we demonstrate that eight motor complete SCI (C5–C6) are still able to task-modulate in real-time activity populations neurons residual pathways. In all participants tested, identified groups units under voluntary control encoded various movements. The unit discharges were mapped into more than 10 degrees freedom,...
ABSTRACT Background The goal of this study was to examine the effects spinal cord stimulation (SCS) on muscle activity during walking after lower-limb amputation. Amputation results in a loss sensory feedback and alterations gait biomechanics, including co-contractions antagonist muscles about knee ankle, reduced pelvic obliquity range-of-motion drop. SCS can restore sensation missing limb, but its activation biomechanics have not been studied people with Methods This case included...
In this study human motor cortical activity was recorded with a customized micro-ECoG grid during individual finger movements.The quality of the neural signals characterized in frequency domain from three different perspectives: (1) coherence between electrodes, (2) modulation by movement, and (3) accuracy movement decoding.It found that, for high band , neighboring electrodes 0.3.In addition,