A5004090819- Neurological disorders and treatments
- Pain Management and Treatment
- Pain Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Migraine and Headache Studies
- Muscle activation and electromyography studies
- Vagus Nerve Stimulation Research
- Transcranial Magnetic Stimulation Studies
- EEG and Brain-Computer Interfaces
- Botulinum Toxin and Related Neurological Disorders
- Musculoskeletal pain and rehabilitation
- Glioma Diagnosis and Treatment
- Trigeminal Neuralgia and Treatments
- Genetic Neurodegenerative Diseases
- Motor Control and Adaptation
- MRI in cancer diagnosis
- Heart Rate Variability and Autonomic Control
- Intracranial Aneurysms: Treatment and Complications
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine regulation and behavior
- Sympathectomy and Hyperhidrosis Treatments
- Neuroscience and Neural Engineering
- Meningioma and schwannoma management
Friedrich-Alexander-Universität Erlangen-Nürnberg
2019-2024
Universitätsklinikum Erlangen
2020-2024
University Hospital Heidelberg
2011-2024
Heidelberg University
2011-2024
University Medical Centre Mannheim
2024
Schiller International University
2023
University Hospital Bonn
2015-2020
University of Bonn
2014-2019
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2018-2019
Universitätsklinik für Stereotaktische Neurochirurgie
2018
Deep brain stimulation (DBS) of the posterior hypothalamus was found to be effective in treatment drug-resistant chronic cluster headache. We report results a multicentre case series six patients with headache whom DBS performed. Electrodes were implanted stereotactically ipsilateral according published coordinates 2 mm lateral, 3 and 5 inferior referenced mid-AC-PC line. Microelectrode recordings at target revealed single unit activity mean discharge rate 17 Hz (range 13-35 Hz, n = 4). Out...
<h3>Objectives:</h3> Stimulation-induced hypokinetic gait disorders with freezing of (FOG) have been reported only recently as adverse effects deep brain stimulation (DBS) the globus pallidus internus (GPi) in patients dystonia. The aim this work was to determine frequency and nature GPi-DBS–induced phenomenon. <h3>Methods:</h3> We retrospectively screened our database dystonia who underwent DBS. Patients focal, segmental, or generalized primary tardive origin no disorder due lower limb...
The debilitating nature of migraine and challenges associated with treatment-refractory have a profound impact on patients. With the need for alternatives to pharmacologic agents, vagus nerve stimulation has demonstrated efficacy in primary headache disorders. We investigated use cervical non-invasive (nVNS) acute treatment prevention attacks episodic chronic (EM CM) evaluated nVNS migraine-associated sleep disturbance, disability, depressive symptoms. Twenty patients were enrolled this...
Background: Aneurysmal subarachnoid hemorrhage (aSAH) is still a fatal and morbid disease, although bleeding aneurysms can be secured in almost all cases. Occurrence of post-SAH complications including cerebral vasospasm, delayed ischemia, hydrocephalus, epilepsy, infections are the main determinants clinical outcome. Hence, it important to search for early predictors specific treat these properly. Both cellular molecular (cytokines) inflammation play key role after aSAH during phase...
The purpose of our study was to identify the low-dimensional latent components, defined hereafter as motor unit modes, underlying discharge rates units in two knee extensors (vastus medialis and lateralis, eight men) hand muscles (first dorsal interossei thenars, seven men one woman) during submaximal isometric contractions. Factor analysis identified independent modes that captured most covariance rates. We found divergent distributions for vastii muscles. On average, 75% thenar first...
Abstract Paralysis of the muscles controlling hand dramatically limits quality life for individuals living with spinal cord injury (SCI). Here, a non-invasive neural interface, we demonstrate that eight motor complete SCI (C5–C6) are still able to task-modulate in real-time activity populations neurons residual pathways. In all participants tested, identified groups units under voluntary control encoded various movements. The unit discharges were mapped into more than 10 degrees freedom,...
The precise initial characterization of contrast-enhancing brain tumors has significant consequences for clinical outcomes. Various novel neuroimaging methods have been developed to increase the specificity conventional magnetic resonance imaging (cMRI) but also increased complexity data analysis. Artificial intelligence offers new options manage this challenge in settings. Here, we investigated whether multiclass machine learning (ML) algorithms applied a high-dimensional panel radiomic...
Abstract Objective. High-density surface electromyography (HD-sEMG) allows the reliable identification of individual motor unit (MU) action potentials. Despite accuracy in decomposition, there is a large variability number identified MUs across individuals and exerted forces. Here we present systematic investigation anatomical neural factors that determine this variability. Approach . We investigated influence on HD-sEMG such as synchronization MU discharges, distribution territories,...
In Eritrea, facility delivery rates show great discrepancy within urban centers. This study was conducted in Akordet, a multi-cultural lowland town of Gash-Barka Region, aiming at assessing the factors influencing delivery.A community based analytical cross-sectional among total 282 mothers who gave birth 2 years preceding data collection time. Data carried out by going house-to-house and interviewing using structured closed ended questionnaire. Bivariate multivariate logistic regressions...
Tardive dystonia usually occurs with a delay after neuroleptic exposure in patients major psychosis. A subgroup of patients, however, is given such medication for "mild depression" or "neurasthenia." dystonia, general, may respond favorably to pallidal deep brain stimulation (DBS). Nevertheless, it remains unclear thus far whether not similar beneficial outcome achieved DBS different subgroups tardive dystonia. Four women (mean age 59 years at surgery) underwent stereotactic the frame an...
Introduction: The treatment of neuropathic and central pain still remains a major challenge. Thalamic deep brain stimulation (DBS) involving various target structures is therapeutic option which has received increased re-interest. Beneficial results have been reported in several more recent smaller studies, however, there lack prospective studies on larger series providing long term outcomes. Methods: Forty patients with refractory syndromes underwent stereotactic bifocal implantation DBS...
The mutational status of the isocitrate dehydrogenase (IDH) gene plays a key role in treatment glioma patients because it is known to affect energy metabolism pathways relevant glioma. Physio-metabolic magnetic resonance imaging (MRI) enables non-invasive analysis oxygen and tissue hypoxia as well associated neovascularization microvascular architecture. However, evaluating such complex neuroimaging data requires computational support. Traditional machine learning algorithms simple deep...