A5101700102- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Cerebrospinal fluid and hydrocephalus
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Neural Engineering
- Transcranial Magnetic Stimulation Studies
- Immune cells in cancer
- Neurosurgical Procedures and Complications
- Neurological and metabolic disorders
- Head and Neck Surgical Oncology
- Macrophage Migration Inhibitory Factor
- Fetal and Pediatric Neurological Disorders
- Obsessive-Compulsive Spectrum Disorders
- Vascular Malformations Diagnosis and Treatment
- Trigeminal Neuralgia and Treatments
- Neurofibromatosis and Schwannoma Cases
- Neural dynamics and brain function
- Spinal Dysraphism and Malformations
- Neuroscience and Neuropharmacology Research
- Spinal Fractures and Fixation Techniques
- EEG and Brain-Computer Interfaces
Medizinische Hochschule Hannover
2016-2025
Charité - Universitätsmedizin Berlin
2006-2025
University Hospital Bonn
2017-2025
John Wiley & Sons (United States)
2023-2024
Witten/Herdecke University
2021
Hearing4all
2017-2020
International Neuroscience Institute
2007-2017
Emory University
2017
Leibniz University Hannover
2007-2015
Institute of Medical Microbiology and Hygiene
2015
to provide a revised version of earlier guidelines published in 2006.primary dystonias are chronic and often disabling conditions with widespread spectrum mainly young people.primary classified as pure dystonia, dystonia plus or paroxysmal syndromes. Assessment should be performed using validated rating scale for dystonia. Genetic testing may after establishing the clinical diagnosis. DYT1 is recommended patients primary limb onset before age 30, those an affected relative early-onset DYT6...
Deep brain stimulation of the globus pallidus internus alleviates involuntary movements in patients with dystonia. However, mechanism is still not entirely understood. One hypothesis that deep suppresses abnormally enhanced synchronized oscillatory activity within motor cortico-basal ganglia network. Here, we explore stimulation-induced modulation pathological low frequency (4–12 Hz) pallidal has been described local field potential recordings Therefore, potentials were recorded from 16...
Adaptive deep brain stimulation (aDBS) is a promising concept for feedback-based neurostimulation, with the potential of clinical implementation sensing-enabled Percept neurostimulator. We aim to characterize chronic electrophysiological activity during and validate beta-band as biomarker bradykinesia. Subthalamic was recorded stepwise amplitude increase OFF medication in 10 Parkinson's patients rest finger tapping. Offline analysis wavelet-transformed assessment inter-variable relationships...
Pathologically increased beta power has been described as a biomarker for Parkinson's disease (PD) and related to prolonged bursts of subthalamic synchronization. Here, we investigate the association between dynamics motor impairment in cohort 106 patients ON- OFF-medication state, using two different methods burst determination. We report frequency-specific correlation low duration with OFF dopaminergic medication. Furthermore, reduction correlated significantly symptom alleviation through...
Abstract Shoulder‐hand syndrome developed in 36 (27%) of 132 hemiplegic patients a prospective study. Subluxation, paresis the shoulder girdle, moderate spasticity, and deficits confrontation visual field testing were major risk factors. In placebo‐controlled, nonblinded trial, 31 became almost symptom free within 10 days' treatment with low doses oral corticosteroids. Shoulder joint capsules taken at autopsy 7 showed signs previous trauma affected shoulder. second part this study on another...
Background and Purpose There is some evidence from previous studies that idiopathic normal-pressure hydrocephalus (NPH) of the elderly might be linked to vascular leukoencephalopathy. The purpose this study was examine prevalence impact risk factors diseases in NPH compared with a control cohort. Methods arterial hypertension; diabetes mellitus; hypercholesterolemia; hyperlipidemia; smoking; obesity; cardiac, cerebrovascular, other arteriosclerotic assessed 65 patients NPH. findings were...
We investigated the effect of periventricular and deep white matter lesions (DWMLs) on outcome after cerebrospinal fluid shunting in a prospective series elderly patients with idiopathic normal-pressure hydrocephalus.White were assessed T2-weighted magnetic resonance scans according to standard protocol 41 hydrocephalus who underwent subsequent shunting. In all patients, diagnosis had been established preoperatively by clinical diagnostic investigations.At mean follow-up 16 months,...
<h3>Background</h3> For patients with psychiatric illnesses remaining refractory to 'standard' therapies, neurosurgical procedures may be considered. Guidelines for safe and ethical conduct of such have previously independently been proposed by various local regional expert groups. <h3>Methods</h3> To expand on these earlier documents, representative members continental international societies, joined efforts further elaborate adopt a pragmatic worldwide set guidelines. These are intended...