A5016952998- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Neuroscience and Neural Engineering
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Botulinum Toxin and Related Neurological Disorders
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Liver Disease Diagnosis and Treatment
- Muscle activation and electromyography studies
- Autism Spectrum Disorder Research
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Kawasaki Disease and Coronary Complications
- Speech and Audio Processing
- Liver Diseases and Immunity
Heinrich Heine University Düsseldorf
2020-2025
Brigham and Women's Hospital
2024-2025
Harvard University
2025
Düsseldorf University Hospital
2024-2025
Circuit Therapeutics (United States)
2024-2025
Adaptive deep brain stimulation (aDBS) is a promising concept for feedback-based neurostimulation, with the potential of clinical implementation sensing-enabled Percept neurostimulator. We aim to characterize chronic electrophysiological activity during and validate beta-band as biomarker bradykinesia. Subthalamic was recorded stepwise amplitude increase OFF medication in 10 Parkinson's patients rest finger tapping. Offline analysis wavelet-transformed assessment inter-variable relationships...
Abstract This case of secondary sclerosing cholangitis (SSC‐CIP) emphasizes the need to provide follow‐up care for patients that have recovered from COVID‐19 in order understand complexity SARS‐CoV‐2 associated sequela.
Deep brain stimulation is an efficacious treatment for dystonia. While the internal pallidum serves as primary target, recently, of subthalamic nucleus (STN) has been investigated. However, optimal targeting within this structure and its surroundings have not studied in depth. Indeed, historical targets that used surgical dystonia are directly adjacent to STN. Further, multiple types exist, outcomes variable, suggesting all would profit maximally from same target. Therefore, a thorough...
Although subthalamic deep brain stimulation (DBS) is a highly-effective treatment for alleviating motor dysfunction in patients with Parkinson's disease (PD), clinicians currently lack reliable neurophysiological correlates of clinical outcomes optimizing DBS parameter settings, which may contribute to inefficacies. One that could aid efficacy the orientation current administered, albeit precise mechanisms underlying optimal contact orientations and associated benefits are not well...
The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily the novel uses of existing technology as well next-generation technology. Our keynote speaker shared vision using neuro artificial intelligence predict depression brain electrophysiology. Innovative applications are currently being explored stroke, disorders consciousness, and sleep, while established treatments...
Deep Brain Stimulation (DBS) is a neurosurgical procedure that involves implanting electrodes into specific brain regions to treat disorders. Accurate reconstruction of electrode placement crucial for treatment optimization. Several systems, such as Lead-DBS, have been developed reconstruct DBS electrodes, and typically require expert user input. However, open datasets with reference localizations are not available, posing challenge train research personnel on accurate use these methods. In...
Abstract Background Deep brain stimulation ( DBS ) is an effective treatment option for patients with Parkinson's disease PD ). However, clinical programming remains challenging segmented electrodes. Objective Using novel sensing‐enabled neurostimulators, we investigated local field potentials LFPs and their modulation by to assess whether electrophysiological biomarkers may facilitate in chronically implanted patients. Methods Sixteen (31 hemispheres) electrodes the subthalamic nucleus a...
Bradykinesia is a behavioral manifestation that contributes to functional dependencies in later life. However, the current state of bradykinesia indexing primarily relies on subjective, time-averaged categorizations motor deficits, which often yield poor reliability. Herein, we used time-resolved analyses accelerometer recordings during standardized movements, data-driven factor analyses, and linear mixed effects models (LMEs) quantitatively characterize general, task- therapy-specific...
Abstract Subthalamic deep brain stimulation (STN-DBS) is an effective therapy for alleviating motor symptoms in people with Parkinson’s disease (PwP), although some may not receive optimal clinical benefits. One potential mechanism of STN-DBS involves antidromic activation the hyperdirect pathway (HDP), thus suppressing cortical beta synchrony to improve function, albeit precise mechanisms underlying DBS parameters are well understood. To address this, 18 PwP completed a 2 Hz monopolar left...
Bradykinesia is a cardinal hallmark of Parkinson's disease (PD). Improvement in bradykinesia an important signature effective treatment. Finger tapping commonly used to index bradykinesia, albeit these approaches largely rely on subjective clinical evaluations. Moreover, recently developed automated scoring tools are proprietary and not suitable for capturing intraday symptom fluctuation. We assessed finger (i.e., Unified Disease Rating Scale (UPDRS) item 3.4) 37 people with (PwP) during...
Abstract Deep brain stimulation (DBS) is an established treatment for Parkinson’s disease. Still, DBS parameter programming currently follows a tedious trial-and-error process. DBS-evoked cortical potentials (EP) might guide selection but this concept has not yet been tested. Further, mounting wet EEG systems too time-consuming to scale in outpatient clinic settings. Here, we test the utility of novel method that leverages spatial pattern EP using dry setup. We acquired 58 hemispheres...
Deep brain stimulation (DBS) has significant effects on motor symptoms in Parkinson's disease (PD), but existing studies the effect of DBS speech are rather inconclusive. It is assumed that deficits auditory-motor integration strongly contribute to Parkinsonian pathology. The aim present study was assess whether subthalamic can modulate these deficits. 20 PD patients (15 male, 5 female; 62.4 ± 6.7 years) with were exposed pitch-shifted acoustic feedback during vowel vocalization and...
Deep brain stimulation is a viable and efficacious treatment option for dystonia. While the internal pallidum serves as primary target, more recently, of subthalamic nucleus (STN) has been investigated. However, optimal targeting within this structure its complex surroundings have not studied in depth. Indeed, multiple historical targets that used surgical dystonia are directly adjacent to STN. Further, types exist, outcomes variable, suggesting all would profit maximally from exact same...
The neuromodulator acetylcholine has been suggested to govern learning under uncertainty. Here, we investigated the role of muscarinic receptors in reward-guided and decision making different degrees We administered M1 antagonist biperiden (4 mg) healthy male participants (n = 43) a within-subjects, placebo-controlled design. Participants performed two tasks that both involved choices between options characterized by attributes, reward probability magnitude. In gambling task, attributes were...
Abstract Subthalamic deep brain stimulation is effective in alleviating motor symptoms Parkinson’s disease. Establishing the clinically best settings often requires time-consuming test sessions and creates a need for biomarkers to optimize this process. While stimulation-evoked cortical responses have been proposed as such neurophysiological marker, their relationship performance has not yet studied systematically. For aim, we recorded finger-tapping movements evoked by different amplitudes...
Abstract Background Deep brain stimulation (DBS) has strong beneficial effects for treating movement disorders. The related cortical mechanisms can be studied with magnetoencephalography (MEG) during active DBS. However, MEG is prone to artefacts induced by the electrical and of ferromagnetic DBS components. Although might vary between devices from different manufacturers, no such comparison been performed. To date, combined MEG-DBS studies have conducted within Yokogawa systems. Objective...