Björn‐Erik Ole Jensen
A5051267193- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- Long-Term Effects of COVID-19
- HIV/AIDS Research and Interventions
- Pneumocystis jirovecii pneumonia detection and treatment
- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 detection and testing
- Liver Disease Diagnosis and Treatment
- HIV-related health complications and treatments
- COVID-19 and healthcare impacts
- Bacterial Identification and Susceptibility Testing
- COVID-19 and Mental Health
- Hepatitis B Virus Studies
- Infection Control and Ventilation
- Respiratory viral infections research
- Parvovirus B19 Infection Studies
- Hepatitis C virus research
- Plant Virus Research Studies
- Chronic Lymphocytic Leukemia Research
- Thermal Regulation in Medicine
- Immune Cell Function and Interaction
- COVID-19 diagnosis using AI
Heinrich Heine University Düsseldorf
2016-2025
Düsseldorf University Hospital
2016-2025
Deutsche AIDS-Gesellschaft
2025
Robert Koch Institute
2024
RWTH Aachen University
2023
University Hospital Cologne
2023
University of Cologne
2023
University Hospital Bonn
2023
Isra University
2020
Arsi University
2020
Abstract Despite scientific evidence originating from two patients published to date that CCR5Δ32/Δ32 hematopoietic stem cell transplantation (HSCT) can cure human immunodeficiency virus type 1 (HIV-1), the knowledge of immunological and virological correlates is limited. Here we characterize a case long-term HIV-1 remission 53-year-old male who was carefully monitored for more than 9 years after allogeneic HSCT performed acute myeloid leukemia. sporadic traces DNA detected by droplet...
Monoclonal antibodies (mAb) have been introduced as a promising new therapeutic approach against SARS-CoV-2. At present, there is little experience regarding their clinical effects in patient populations underrepresented trials, e.g. immunocompromised patients. Additionally, it not well known to what extent SARS-CoV-2 treatment with monoclonal could trigger the selection of immune escape viral variants.After identifying patients rebound under bamlanivimab, we characterized...
Since May 2022, increasing numbers of monkeypox virus (MPXV) infections have been reported from across Europe and North America. Studies, mainly Africa, suggested a higher risk for severe MPXV cases in people living with HIV.This was retrospective study all confirmed observed the participating centres since 19 2022. We conducted chart review to evaluate clinical characteristics, comorbidities, coinfections, including HIV, viral hepatitis, sexually transmitted (STIs).By 30 June total 546 were...
Investigating outcomes of hospitalised COVID-19 patients throughout the pandemic is crucial to understand impact different SARS-CoV-2 variants. We compared 28-day in-hospital mortality Wild-type, Alpha, Delta, and Omicron variant infections. Whether difference in risk by varied age was also evaluated. conducted a cohort study including ≥18 years, between 2020 02-01 2022-10-15 with positive test, from nine countries. Variant classified based on sequenced viruses or national public metadata....
Abstract This case of secondary sclerosing cholangitis (SSC‐CIP) emphasizes the need to provide follow‐up care for patients that have recovered from COVID‐19 in order understand complexity SARS‐CoV‐2 associated sequela.
Metabolic disorders have been identified as major risk factors for severe acute courses of COVID-19. With decreasing numbers infections in many countries, the long COVID syndrome (LCS) represents next challenge pandemic management, warranting precise definition LCS development.We 50,402 COVID-19 patients Disease Analyzer database (IQVIA) featuring data from 1056 general practices Germany. Multivariate logistic regression analysis was used to identify development LCS.Of included into this...
Abstract Background Monoclonal antibodies (mAbs) that target severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are predominantly less effective against Omicron variants. Immunocompromised patients often experience prolonged viral shedding, resulting in an increased risk of escape. Methods In observational, prospective cohort, 57 infected with variants who received sotrovimab alone or combination remdesivir were followed. The study end points a decrease SARS-CoV-2 RNA <106...
Prolonged shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been observed in immunocompromised hosts. Early monotherapy with direct-acting antivirals or monoclonal antibodies, as recommended by the international guidelines, does not prevent this certainty. Dual therapies may therefore have a synergistic effect.
Abstract Objective Subacute thyroiditis (SAT) is a painful inflammatory disorder of the thyroid gland, which – after phase thyrotoxicosis leads to transient, or less frequently permanent hypothyroidism. Apart from strong association with specific HLA alleles, causes are uncertain. Viral disease has been hypothesised as trigger, Enteroviruses, namely Echoviruses and Coxsackieviruses, showing seasonal distribution that coincides incidence SAT. In first year COVID-19 pandemic, strict hygiene...
We whole-genome sequenced 55 SARS-CoV-2 isolates from Germany to investigate outbreaks in 2020 the Heinsberg district and Düsseldorf. While genetic structure of outbreak indicates a clonal origin, reflecting superspreading dynamics mid-February during carnival season, distinct viral strains were circulating Düsseldorf March, city's international links. Limited detection area despite geographical proximity may reflect efficient containment contact-tracing efforts.
Patients with cardiac disease are considered high risk for poor outcomes following hospitalization COVID-19. The primary aim of this study was to evaluate heterogeneity in associations between various heart subtypes and in-hospital mortality.
Abstract Background In May 2022, a multi-national mpox outbreak was reported in several non-endemic countries. The only licensed treatment for the European Union is orally available small molecule tecovirimat, which Orthopox viruses inhibits function of major envelope protein required production extracellular virus. Methods We identified presumably all patients with that were treated tecovirimat Germany between onset 2022 and March 2023 obtained demographic clinical characteristics by...
Summary Overall survival ( OS ) of patients with acquired immunodeficiency syndrome AIDS )‐related Burkitt lymphoma BL ), diffuse large B‐cell DLBCL and plasmablastic PBL was analysed in the German ‐related‐Lymphoma‐Cohort‐Study. Of 291 prospectively included between January 2005 December 2012, 154 had , 103 34 . Two‐year rates were similar (69%) (63%) but lower for (43%). Intermediate (Hazard ratio [ HR ] 4·1 95% confidence interval CI 1·98–8·49) or high 4·92 2·1–11·61) International...
Out of 302 AIDS-related lymphoma (ARL) patients enrolled in the German ARL cohort study, 18 had plasmablastic (PBL). Twelve out (67%) have died with a median survival 4 months (range 0-11 months). In univariate analysis, an intermediate or high international prognostic index score was associated significantly lower overall and progression-free survival. The predominant cause death progressive (67%). Our data indicate that outcome PBL is still very poor.
Abstract Purpose The objective examination of the Post-COVID syndrome (PCS) remains difficult due to heterogeneous definitions and clinical phenotypes. aim study was verify functionality correlates a recently developed PCS score. Methods score applied prospective, multi-center cross-sectoral cohort (in- outpatients with SARS-CoV-2 infection) "National Pandemic Cohort Network (NAPKON, Germany)". Symptom assessment patient-reported outcome measure questionnaires were analyzed at 3 12 months...
In a patient transferred from Togo to Cologne, Germany, Lassa fever was diagnosed 12 days post mortem. Sixty-two contacts in Cologne were categorised according the level of exposure, and gradual infection control measures applied. No clinical signs virus or specific antibodies observed 62 contacts. Thirty-three individuals had direct contact blood, other body fluids tissue patients. Notably, with standard precautions, no transmission occurred between index healthcare workers. However, one...
Abstract Background and purpose During acute coronavirus disease 2019 (COVID‐19) infection, neurological signs, symptoms complications occur. We aimed to assess their clinical relevance by evaluating real‐world data from a multinational registry. Methods analyzed COVID‐19 patients 127 centers, diagnosed between January 2020 February 2021, registered in the European LEOSS (Lean Open Survey on SARS‐Infected Patients) The effects of prior diseases effect outcome were studied using multivariate...
Advanced age, followed by male sex, far poses the greatest risk for severe COVID-19. An unresolved question is extent to which modifiable comorbidities increase of COVID-19-related mortality among younger patients, in whom hospitalization strongly increased 2021. A total 3,163 patients with SARS-COV-2 diagnosis Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort were studied. LEOSS a non-interventional multi-center study established March 2020 investigate epidemiology...
Vaccination against SARS-CoV-2 has been the main tool to contain pandemic. The rush development of 3 vaccines and their expedited approval have led inoculation millions patients around world, leading a containment disease. Despite continuous viral mutations identification weaker variants, severity infections mild, with many being either asymptomatic or recovering at home. Currently focus shifted from host organ damage related infection potential side effects vaccine. Myocarditis reported as...