Moritz Berger
A5080177315- Statistical Methods and Bayesian Inference
- Statistical Methods and Inference
- Advanced Statistical Modeling Techniques
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Advanced Causal Inference Techniques
- Retinal and Optic Conditions
- Psychometric Methodologies and Testing
- COVID-19 Clinical Research Studies
- Alzheimer's disease research and treatments
- Glaucoma and retinal disorders
- Bayesian Methods and Mixture Models
- Dementia and Cognitive Impairment Research
- Ocular Diseases and Behçet’s Syndrome
- SARS-CoV-2 and COVID-19 Research
- Advanced Statistical Methods and Models
- Data Analysis with R
- Statistical Methods in Clinical Trials
- Health Systems, Economic Evaluations, Quality of Life
- Bayesian Modeling and Causal Inference
- Statistical Methods in Epidemiology
- Optimal Experimental Design Methods
- Functional Brain Connectivity Studies
- Sports Science and Education
- Ophthalmology and Visual Impairment Studies
University Hospital Bonn
2017-2025
Zimmer Biomet (Germany)
2017-2025
Institut für Medizinische Biometrie, Informatik und Epidemiologie
2017-2025
University of Bonn
2018-2025
Heidelberg University
2025
University Hospital Heidelberg
2025
Central Institute of Mental Health
2025
University of Sheffield
2024
Heinrich Heine University Düsseldorf
2023
Zimmer Biomet (Netherlands)
2022-2023
Abstract A SARS-CoV2 super-spreading event occurred during carnival in a small town Germany. Due to the rapidly imposed lockdown and its relatively closed community, this was seen as an ideal model investigate infection fatality rate (IFR). Here, 7-day seroepidemiological observational study performed collect information biomaterials from random, household-based population. The number of infections determined by IgG analyses PCR testing. We found that 919 individuals with evaluable status,...
Abstract The world faces an unprecedented SARS-CoV2 pandemic where many critical factors still remain unknown. case fatality rates (CFR) reported in the context of SARS-CoV-2 substantially differ between countries. For infection with its broad clinical spectrum from asymptomatic to severe disease courses, rate (IFR) is more reliable parameter predict consequences pandemic. Here we combined virus RT-PCR testing and assessment for antibodies determine total number individuals infections a...
Abstract Introduction It is uncertain whether subjective cognitive decline (SCD) in individuals who seek medical help serves the identification of initial symptomatic stage 2 Alzheimer's disease (AD) continuum. Methods Cross‐sectional and longitudinal data from multicenter, memory clinic–based DELCODE study. Results The SCD group showed slightly worse cognition as well more subtle functional behavioral symptoms than control (CO). SCD–A+ cases (39.3% all SCD) greater hippocampal atrophy,...
Prolonged shedding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been observed in immunocompromised hosts. Early monotherapy with direct-acting antivirals or monoclonal antibodies, as recommended by the international guidelines, does not prevent this certainty. Dual therapies may therefore have a synergistic effect.
Abstract Neuroinflammation is a hallmark of Alzheimer’s disease (AD) and both positive negative associations individual inflammation-related markers with brain structure cognitive function have been described. We aimed to identify inflammatory signatures CSF immune-related that relate changes cognition across the clinical spectrum ranging from normal aging AD. A panel 16 markers, Aβ42/40 p-tau181 were measured in at baseline DZNE DELCODE cohort ( n = 295); longitudinal observational study...
Summary A popular modeling approach for competing risks analysis in longitudinal studies is the proportional subdistribution hazards model by Fine and Gray (1999. of a risk. Journal American Statistical Association94, 496–509). This widely used continuous event times clinical epidemiological studies. However, it does not apply when are measured on discrete time scale, which likely scenario events occur between pairs consecutive points (e.g., two follow-up visits an study) exact lengths spans...
Abstract Retinopathy of prematurity (ROP) is a frequent cause treatable childhood blindness. The current dependency telemedicine-based ROP screening on cost-intensive equipment does not meet the needs in economically disadvantaged regions. Smartphone-based fundus imaging (SBFI) allows for affordable and mobile examination and, therefore, could facilitate cost-effective low-resources settings. We compared non-contact SBFI conventional contact (CFI) terms feasibility documentation. Twenty-six...
Introduction For quantification of Optical Coherence Tomography Angiography (OCTA) images, Vessel Density (VD) and Skeleton (VSD) are well established parameters different algorithms in use for their calculation. However, comparability, reliability ability to discriminate healthy impaired macular perfusion unclear, yet, potential high clinical relevance. Hence, we assessed comparability test-retest the most common approaches. Materials methods Two consecutive 3×3mm OCTA en face images...
To report the prevalence and topographic distribution of structural characteristics in study participants with age-related macular degeneration (AMD) controls cross-sectional part MACUSTAR (ClinicalTrials.gov Identifier: NCT03349801).European, multicenter cohort study.Overall, 301 eyes subjects early (n = 34), intermediate 168), late AMD 43), as well without any features 56).In (iAMD), presence biomarkers, including pigmentary abnormalities (PAs), pigment epithelium detachment (PED),...
White matter hyperintensities (WMH) in subjects across the Alzheimer's disease (AD) spectrum with minimal vascular pathology suggests that amyloid pathology-not just arterial hypertension-impacts WMH, which turn adversely influences cognition. Here we seek to determine effect of both hypertension and Aβ positivity on their impact cognition.We analysed data from a low profile normal cognition (NC), subjective cognitive decline (SCD), amnestic mild impairment (MCI) enrolled ongoing...
Abstract As most rare diseases, intermediate uveitis lacks reliable endpoints necessary for randomized clinical trials. Therefore, we investigated longitudinal changes of retinal and choriocapillaris perfusion on optical coherence tomography angiography (OCT-A) in their prognostic value future best corrected visual acuity (BCVA) central thickness (CRT). In this retrospective, cohort study eyes patients with were imaged by swept-source OCT-A (macula-centered 3 × mm; PLEX Elite 9000, Zeiss)...
Abstract: Time-to-event models are a popular tool to analyse data where the outcome variable is time occurrence of specific event interest. Here, we focus on analysis time-to-event outcomes that either intrinsically discrete or grouped versions continuous times. In literature, there exists variety regression methods for such data. This tutorial provides an introduction how these can be applied using open source statistical software. particular, consider semiparametric extensions comprising...
In the modeling of ordinal responses in psychological measurement and survey-based research, response styles that represent specific answering patterns respondents are typically ignored. One consequence is estimates item parameters can be poor considerably biased. The focus here on a tendency to extreme or middle categories. An extension partial credit model proposed explicitly accounts for this style. contrast existing approaches, which based finite mixtures, explicit person-specific style...
Abstract Background There is an unmet need for treatment options in intermediate age-related macular degeneration (iAMD). However, any new interventions to be tested clinical trials, novel currently unavailable endpoints developed. Thus, the MACUSTAR study aims develop and evaluate functional, structural, patient-reported candidate use future iAMD trials. Methods The protocol describes a low-interventional multicenter employing two-part design. cross-sectional part (total duration, 1 month)...
Abstract Background In preclinical Alzheimer’s disease, it is unclear why some individuals with amyloid pathologic change are asymptomatic (stage 1), whereas others experience subjective cognitive decline (SCD, stage 2). Here, we examined the association of 1 vs. 2 structural brain reserve in memory-related regions. Methods We tested whether volumes hippocampal subfields and parahippocampal regions were larger at compared to amyloid-negative older adults (healthy controls, HCs). also would...
Spinocerebellar ataxia type 3/Machado-Joseph disease is the most common autosomal dominant ataxia. In view of development targeted therapies, knowledge early biomarker changes needed. We analyzed cross-sectional data 292 spinocerebellar mutation carriers. Blood concentrations mutant ATXN3 were high before and after onset, whereas neurofilament light deviated from normal 13.3 years onset. Pons cerebellar white matter volumes decreased 2.2 0.6 propose a staging model that includes stage...
Abstract Background Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominantly inherited adult-onset disease. We aimed to describe longitudinal changes in clinical and biological findings identify predictors for progression. Methods used data from participants enrolled the ESMI cohort collected between Nov 09, 2016 July 18, 2023. The freeze included 14 sites five European countries United States. assessed with Scale Assessment Rating of Ataxia (SARA). measured disease-specific mutant...
Modeling the ratio of two dependent components as a function covariates is frequently pursued objective in observational research. Despite high relevance this topic medical studies, where biomarker ratios are often used surrogate endpoints for specific diseases, existing models commonly based on oversimplified assumptions, assuming e.g. independence or strictly positive associations between components. In paper, we overcome such limitations and propose regression model marginal distributions...
Impaired perivascular clearance has been suggested as a contributing factor to the pathogenesis of Alzheimer disease (AD). However, it remains unresolved when anatomy space (PVS) is altered during AD progression. Therefore, this study investigates association between PVS volume and progression in cognitively unimpaired (CU) individuals, both with without subjective cognitive decline (SCD), those clinically diagnosed mild impairment (MCI) or AD.
Tree-structured models are a powerful alternative to parametric regression if non-linear effects and interactions present in the data. Yet, classical tree-structured might not be appropriate data comes clusters of units, which requires taking dependence observations into account. This is, for example, case cross-national studies, as presented here, where country-specific should neglected. To address this issue, we flexible approach that achieves sparse modeling unit-specific identifies...