A5036528855- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Alzheimer's disease research and treatments
- Neural and Behavioral Psychology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Heart Rate Variability and Autonomic Control
- Tryptophan and brain disorders
- Dementia and Cognitive Impairment Research
- Migraine and Headache Studies
- Optical Imaging and Spectroscopy Techniques
- Advanced MRI Techniques and Applications
- Neurogenesis and neuroplasticity mechanisms
- Action Observation and Synchronization
- Hearing Impairment and Communication
- Neurological Disease Mechanisms and Treatments
- Pain Management and Treatment
- Motor Control and Adaptation
- MRI in cancer diagnosis
- Head and Neck Surgical Oncology
- Nerve injury and regeneration
German Center for Neurodegenerative Diseases
2020-2024
Universitätsmedizin Greifswald
2018-2024
Charité - Universitätsmedizin Berlin
2017-2021
Freie Universität Berlin
2018-2021
Humboldt-Universität zu Berlin
2018-2020
American University of Beirut
2016
Transcranial direct current stimulation (tDCS) modulates human behavior, neuronal patterns, and metabolite concentrations, with exciting potential for neurorehabilitation. However, the understanding of tDCS-induced alterations on level is incomplete, conclusions from young adults, in whom majority studies have been conducted, cannot be easily transferred to older populations. Here, we investigated effects adults ( N = 48; age range, 50–79 years) using magnetic resonance spectroscopy quantify...
Abstract Transcranial direct current stimulation (tDCS) augments training-induced cognitive gains, an issue of particular relevance in the aging population. However, negative outcomes have been reported as well, and few studies so far evaluated impact tDCS on episodic memory formation elderly cohorts. The heterogeneity previous findings highlights importance elucidating neuronal underpinnings tDCS-induced modulations, determining individual predictors a positive response. In present study,...
Abstract Neuroinflammation is a hallmark of Alzheimer’s disease (AD) and both positive negative associations individual inflammation-related markers with brain structure cognitive function have been described. We aimed to identify inflammatory signatures CSF immune-related that relate changes cognition across the clinical spectrum ranging from normal aging AD. A panel 16 markers, Aβ42/40 p-tau181 were measured in at baseline DZNE DELCODE cohort ( n = 295); longitudinal observational study...
Transcranial direct current stimulation (tDCS) has been studied extensively for its potential to enhance human cognitive functions in healthy individuals and treat impairment various clinical populations. However, little is known about how tDCS modulates the neural networks supporting cognition complex interplay with mediating factors that may explain frequently observed variability of effects within between studies. Moreover, research this field characterized by substantial methodological...
Adult neural stem cells (aNSCs) are relatively quiescent populations that give rise to distinct neuronal subtypes throughout life, yet, at a very low rate and restricted differentiation potential. Thus, identifying the molecular mechanisms control their cellular expansion is critical for regeneration after brain injury. Loss of Retinoblastoma protein, Rb, leads several defects in cell cycle as well migration during development. Here, we investigated role Rb adult neurogenesis olfactory bulb...
Age-related deterioration in white and gray matter is linked to cognitive deficits. Reduced microstructure of the fornix, major efferent pathway hippocampus, volume dentate gyrus (DG), may cause age-associated memory decline. However, linkage between these anatomical determinants retrieval healthy aging are poorly understood. In 30 older adults, we acquired diffusion tensor T1-weighted images for individual deterministic tractography estimation. A task, administered outside scanner assess...
Sustained environmental enrichment (EE) through a variety of leisure activities may decrease the risk developing Alzheimer's disease. This cross-sectional cohort study investigated association between long-term EE in young adulthood middle life and microstructure fiber tracts associated with memory system older adults.N = 201 cognitively unimpaired participants (≥ 60 years age) from DZNE-Longitudinal Cognitive Impairment Dementia Study (DELCODE) baseline were included. Two groups higher (n...
Transcranial direct current stimulation (tDCS) is a noninvasive brain technique that allows the modulation of excitability and plasticity human brain. Focalized tDCS setups use specific electrode arrangements to constrain flow circumscribed regions. However, effectiveness focalized can be compromised by positioning errors on scalp, resulting in significant reductions dose reaching target regions for tDCS. Electrode placement guided neuronavigation based individual's head anatomy derived from...
Action comprehension that is related to language or gestural integration has been shown engage the motor system in brain, thus providing preliminary evidence for gestural-verbal embodiment concept. Based on involvement of sensorimotor cortex (M1) processing, we aimed further explore its role cognitive necessary integration. As such, applied anodal (excitatory) and sham transcranial direct current stimulation (tDCS) over left M1 (with reference electrode contralateral supraorbital region)...
Abstract Background Inflammation, vascular disease and Alzheimer’s Disease (AD) appear to be closely linked. We recently showed that increased risk relates certain inflammatory profiles in CSF the DELCODE cohort (Hayek et al, AAIC 2022). Moreover, we found cerebrovascular alterations posterior‐midline regions including precuneus subjects at for AD with cognitive impairment relative controls (Behrenbruch al). Here, examined contributions of related markers resting‐state fMRI BOLD fluctuations...
Abstract Background Degeneration of the Locus coeruleus (LC) is associated with Alzheimer’s disease (AD) pathology and cognitive decline. Recent evidence from animal models indicates that this relationship may be mediated by neuroinflammation. Here we examined how LC MRI contrast related to CSF biomarkers neuroinflammation in humans. Method The as well Substantia nigra (SN) were visualized segmented using neuromelanin‐sensitive T 1 ‐weighted FLASH‐MRI images acquired at 3T values calculated...
Abstract Background Inflammation, vascular disease and Alzheimer’s Disease (AD) appear to be closely linked. We recently showed that increased risk relates certain inflammatory profiles in CSF the DELCODE cohort (Hayek et al, AAIC 2022). Moreover, we found cerebrovascular alterations posterior‐midline regions including precuneus subjects at for AD with cognitive impairment relative controls (Behrenbruch al). Here, examined contributions of related markers resting‐state fMRI BOLD fluctuations...
Abstract Background Subjective Cognitive Decline (SCD) may represent the earliest clinical manifestation of Alzheimer’s disease (AD) (Jessen et al. 2014). In individuals with SCD and mild cognitive impairment (MCI), changes in white matter (WM) microstructure have been shown using diffusion weighted (DW) imaging (Brueggen 2019). However, it is unknown to which extent these alterations are associated psychological deficits. Thus, this study aims investigate relationship between WM tract...
Abstract Background Neuroinflammation is a hallmark of Alzheimer ́s disease (AD) and other neurodegenerative disorders likely to be triggered throughout different stages the disease. Microglia Astrocytes are main resident glia that mediate neuroinflammation through production cytokines, chemokines neuroinflammatory biomarkers. Inflammatory processes have been implicated in pathogenesis cerebrovascular white matter (WM) injury. However, imaging studies on contribution inflammation WM...