Tessa Kerre
A5048593632- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Acute Myeloid Leukemia Research
- Biosimilars and Bioanalytical Methods
- Cytomegalovirus and herpesvirus research
- Acute Lymphoblastic Leukemia research
- Cancer Immunotherapy and Biomarkers
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Mesenchymal stem cell research
- Virus-based gene therapy research
- Childhood Cancer Survivors' Quality of Life
- Monoclonal and Polyclonal Antibodies Research
- Single-cell and spatial transcriptomics
- Zebrafish Biomedical Research Applications
- Polyomavirus and related diseases
- Neutropenia and Cancer Infections
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Pluripotent Stem Cells Research
- Blood disorders and treatments
Ghent University Hospital
2016-2025
Ghent University
2016-2025
Cancer Research Institute Ghent
2018-2025
VIB-UGent Center for Medical Biotechnology
2024
Bipar
2013
University of Toronto
2011
Rode Kruis-Vlaanderen
2002
Ludwig Cancer Research
2002
Rotterdam University of Applied Sciences
2002
Vlaams Instituut voor Biotechnologie
1999
Human embryonic stem cells (hESC) are pluripotent cells. A major challenge in the field of hESC is establishment specific differentiation protocols that drives down a particular lineage fate. So far, attempts to generate T from vitro were unsuccessful. In this study, we show can be generated hESC-derived hematopoietic precursor present zones (HZs). These morphologically similar blood islands during development, and formed when cultured on OP9 stromal Upon subsequent transfer these HZs...
Recent clinical trials have shown that adoptive chimeric antigen receptor (CAR) T cell therapy is a very potent and possibly curative option in the treatment of B leukemias lymphomas. However, targeting single may not be sufficient, relapse due to emergence negative leukemic cells occur. A potential strategy counter outgrowth escape variants broaden specificity CAR by incorporation multiple recognition domains tandem. As proof concept, we here describe bispecific which chain variable...
Immunocompromised patients are at increased risk of severe COVID-19 and impaired vaccine response. In this observational prospective study, we evaluated immunogenicity the BNT162b2 mRNA in cohorts primary or secondary immunocompromised patients.Five clinical groups [primary immunodeficiency (PID) (n=57), people living with HIV (PLWH) (n=27), a broad variety underlying rheumatologic (n=23) homogeneous (multiple sclerosis) neurologic (n=53) conditions chronic kidney disease (CKD) (n=39)] as...
Neutropenia may limit the use of valganciclovir treatment for cytomegalovirus (CMV) infection following hematopoietic cell transplant (HCT). A phase 2 study indicated efficacy maribavir with fewer treatment-limiting toxicities than valganciclovir.
Non-small cell lung cancer (NSCLC) is known for high relapse rates despite resection in early stages. Here, we present the results of a phase I clinical trial which dendritic (DC) vaccine targeting patient-individual neoantigens evaluated patients with resected NSCLC. Vaccine manufacturing feasible six 10 enrolled patients. Toxicity limited to grade 1-2 adverse events. Systemic T responses are observed five out vaccinated patients, remaining detectable up 19 months post vaccination....
Ataxia telangiectasia and Rad3-related (ATR) kinase its interacting protein ATRIP orchestrate the replication stress response. Homozygous splice variants in gene, resulting deficiency, were identified two patients of independent ancestry with microcephaly, primordial dwarfism, recurrent infections. The c.829+5G>T patient exhibited lymphopenia, poor vaccine responses, autoimmune features hemolytic anemia, neutropenia. Immunophenotyping revealed reduced CD16+/CD56dim NK cells absent...
In humans, high Notch activation promotes γδ T cell development, whereas lower levels promote αβ-lineage differentiation. How these different signals are generated has remained unclear. We show that differential receptor–ligand interactions mediate this process. Whereas Delta-like 4 supports both TCR-αβ and -γδ Jagged1 induces mainly contrast, Jagged2-mediated primarily results in development represses differentiation by inhibiting TCR-β formation. Consistently, is rescued through...
Abstract The gradual reprogramming of haematopoietic precursors into the T-cell fate is characterized by at least two sequential developmental stages. Following Notch1-dependent lineage specification during which first genes are expressed and myeloid dendritic cell potential lost, specific transcription factors subsequently induce commitment repressing residual natural killer (NK)-cell potential. How these processes regulated in human poorly understood, especially since efficient requires a...
The gut microbiota makes critical contributions to host homeostasis, and its role in the treatment of acute myeloid leukaemia (AML) has attracted attention. We investigated whether microbiome is affected by AML, such changes are associated with cachectic hallmarks. Biological samples clinical data were collected from 30 antibiotic-free AML patients at diagnosis matched volunteers (1:1) a multicenter cross-sectional prospective study. composition functional potential faecal analyzed using...
Abstract The crucial role of Notch signaling in cell fate decisions hematopoietic lineage and T lymphocyte development has been well established mice. Overexpression the intracellular domain mediates signal transduction protein. By retroviral this constitutively active truncated human CD34+ umbilical cord blood progenitor cells, we were able to show that, coculture with stromal MS-5 line, depending on cytokines added, differentiation toward CD19+ B lymphocytes was blocked, CD14+ monocytes...
Immature thymocytes are diverted to the agonist selection pathway before of conventional T cells.
In order to facilitate the diagnostic process for adult patients suffering from a rare disease, Undiagnosed Disease Program (UD-PrOZA) was founded in 2015 at Ghent University Hospital Belgium. this study we report five-year results of our multidisciplinary approach disease diagnostics.Patients referred by healthcare provider, which an underlying is likely, qualify UD-PrOZA evaluation. uses clinical combined with state-of-the-art genomic technologies close collaboration research facilities...
AXL expression has been identified as a prognostic factor in acute myeloid leukemia (AML) and is detectable approximately 50% of AML patients. In this study, we developed AXL-specific single domain antibodies (sdAbs), cross-reactive for both mouse human protein, to non-invasively image treat AXL-expressing cancer cells.
CD70 is an attractive target for chimeric antigen receptor (CAR) T-cell therapy the treatment of both solid and liquid malignancies. However, functionality CD70-specific CAR T cells modest. We optimized a VHH-based (nanoCAR). evaluated nanoCARs in clinically relevant models vitro, using co-cultures nanoCAR with malignant rhabdoid tumor organoids, vivo, diffuse large B-cell lymphoma patient-derived xenograft (PDX) model. Although were highly efficient organoid co-cultures, they showed only...
Although hematopoietic precursor activity can be generated in vitro from human embryonic stem cells, there is no solid evidence for the appearance of multipotent, self-renewing and transplantable cells. This could due to short half-life cells culture or, alternatively, cell-initiated hematopoiesis may cell-independent, similar yolk sac hematopoiesis, generating multipotent progenitors with limited expansion capacity. Since a MYB was reported an excellent marker cell-dependent we MYB-eGFP...
NKR-2 are autologous T cells genetically modified to express a chimeric antigen receptor (CAR) comprising fusion of the natural killer group 2D (NKG2D) with CD3ζ signalling domain, which associates adaptor molecule DNAX-activating protein 10 kDa (DAP10) provide co-stimulatory signal upon ligand binding. NKG2D binds eight different ligands expressed on cell surface many tumour and normally absent non-neoplastic cells. In preclinical studies, demonstrated long-term antitumour activity towards...
Few studies thus far have compared head-to-head different non-myelooablative conditioning regimens for allogeneic hematopoietic cell transplantation (allo-HCT). Here, we report the results of a phase II multicenter randomized study comparing non-myeloablative allo-HCT from HLA-identical siblings (n = 54) or 10/10 HLA-matched unrelated donors 40) with either fludarabine plus 2 Gy total body irradiation (Flu-TBI arm; n 49) 8 TLI + anti-thymocyte globulin (TLI-ATG 45) conditioning. The 180-day...