A5009118615- Nutrition and Health in Aging
- Clinical Nutrition and Gastroenterology
- Diet and metabolism studies
- Muscle metabolism and nutrition
- Metabolism and Genetic Disorders
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Muscle Physiology and Disorders
- Adipose Tissue and Metabolism
- Nitric Oxide and Endothelin Effects
- Nutritional Studies and Diet
- Body Composition Measurement Techniques
- Amino Acid Enzymes and Metabolism
- Enhanced Recovery After Surgery
- Cancer Immunotherapy and Biomarkers
- Aldose Reductase and Taurine
- Gut microbiota and health
- Ubiquitin and proteasome pathways
- Colorectal Cancer Treatments and Studies
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Frailty in Older Adults
- Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
Assistance Publique – Hôpitaux de Paris
2015-2024
Hôpital Cochin
2015-2024
Center for Research and Interdisciplinarity
2024
Université Paris Cité
2014-2023
Délégation Paris 5
2011-2021
Hôtel-Dieu de Paris
2003-2021
Hôpitaux Universitaires Paris-Ouest
2018-2019
Sorbonne Paris Cité
2012-2017
Hôpital Broca
2014-2016
Laboratoire de Biologie et Pharmacologie Appliquée
2003-2016
Previous experimental studies have highlighted that citrulline (CIT) could be a promising pharmaconutrient. However, its pharmacokinetic characteristics and tolerance to loading not been studied date. The objective was characterise the plasma kinetics of CIT in multiple-dosing study design assess effect intake on concentrations other amino acids (AA). effects anabolic hormones were also determined. Eight fasting healthy males underwent four separate oral tests (2, 5, 10 or 15 g CIT) random...
Recent data suggested a role of gut microbiota and antibiotic use on immune checkpoint inhibitors efficacy. We aimed to evaluate the impact early (EUA), blood microbiome plasmatic citrulline (marker intestinal barrier) nivolumab efficacy in non-small cell lung cancer (NSCLC).We included all consecutive patients with advanced NSCLC treated our Department between 2014 2017. Blood was analyzed at month (M) M0 M2. Citrulline rates were evaluated M0, M2, M4 M6.Seventy-two (EUA 42%). Overall...
The gut microbiota makes critical contributions to host homeostasis, and its role in the treatment of acute myeloid leukaemia (AML) has attracted attention. We investigated whether microbiome is affected by AML, such changes are associated with cachectic hallmarks. Biological samples clinical data were collected from 30 antibiotic-free AML patients at diagnosis matched volunteers (1:1) a multicenter cross-sectional prospective study. composition functional potential faecal analyzed using...
Abstract Background Non-occlusive mesenteric ischemia (NOMI) is a challenging diagnosis and associated with extremely high mortality in critically ill patients, particularly due to delayed when complicated by intestinal necrosis. Plasma citrulline intestinal-fatty acid binding protein (I-FABP) have been proposed as potential biomarkers, but never studied prospectively this setting. We aimed investigate diagnostic features, the accuracy of plasma I-FABP diagnose NOMI necrosis well prognosis....
Loss of NBEAL2 function leads to grey platelet syndrome (GPS), a bleeding disorder characterized by macro-thrombocytopenia and α-granule-deficient platelets. A proportion patients with GPS develop autoimmunity through an unknown mechanism, which might be related the proteins interacts with, specifically in immune cells. Here we show comprehensive interactome primary T cells, based on mass spectrometry identification altogether 74 protein association partners. These include LRBA, member same...
Citrulline (CIT) is an endogenous amino acid produced by the intestine. Recent literature has consistently shown CIT to be activator of muscle protein synthesis (MPS). However, underlying mechanism still unknown. Our working hypothesis was that might regulate homeostasis directly through mTORC1/PI3K/MAPK pathways. Because undergoes both interorgan and intraorgan trafficking metabolism, we combined three approaches: in vivo, ex vitro. Using a model malnourished aged rats, supplementation...
Purpose: Taurine depletion is known to induce photoreceptor degeneration and was recently found also trigger retinal ganglion cell (RGC) loss similar the toxicity of vigabatrin. Our objective study topographical RGCs cone photoreceptors, with a distinction between two types (S- L- cones) in an animal model induced taurine depletion. Methods: We used transporter (Tau-T) inhibitor, guanidoethane sulfonate (GES), at concentration 1% drinking water. Spectral-domain optical coherence tomography...
Acute myeloid leukaemia (AML) chemotherapy has been reported to impact gut microbiota composition. In this study, we investigated using a multi -omics strategy the changes in microbiome induced by AML intense therapy and their association with barrier function cachectic hallmarks.10 patients, allocated standard induction (SIC), were recruited. Samples data collected before any therapeutic intervention (T0), at end of SIC (T1) discharge (T4). Gut composition function, markers inflammation,...
Abstract Autoimmune lymphoproliferative syndrome (ALPS) is a primary disorder of lymphocyte homeostasis, leading to chronic lymphoproliferation, autoimmune cytopenia, and increased risk lymphoma. The genetic landscape ALPS includes mutations in FAS , FASLG FADD all associated with apoptosis deficiency, while the role CASP10 defect disease remains debated. In this study, we aimed assess impact variants on pathogenesis. We benefit from thousands analysis datasets performed our Institute’s...