A5014687897- Neutropenia and Cancer Infections
- CAR-T cell therapy research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Blood disorders and treatments
- Bladder and Urothelial Cancer Treatments
- Infant Health and Development
- Immunotherapy and Immune Responses
- Bacterial Identification and Susceptibility Testing
- Cancer Genomics and Diagnostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Non-Invasive Vital Sign Monitoring
- Sarcoma Diagnosis and Treatment
- Breast Lesions and Carcinomas
- Neuroblastoma Research and Treatments
- Computational Drug Discovery Methods
- Urinary and Genital Oncology Studies
- Neuroscience of respiration and sleep
- Heart Rate Variability and Autonomic Control
- Hemodynamic Monitoring and Therapy
- Lung Cancer Research Studies
Hôpital de Jolimont
2018-2022
Cliniques Universitaires Saint-Luc
2017-2020
UCLouvain
2017-2019
Société Française de Médecine d'Urgence
2019
PURPOSE The randomized, open-label, global phase III TROPION-Lung01 study compared the efficacy and safety of datopotamab deruxtecan (Dato-DXd) versus docetaxel in patients with pretreated advanced/metastatic non–small cell lung cancer (NSCLC). METHODS Patients received Dato-DXd 6 mg/kg or 75 mg/m 2 once every 3 weeks. Dual primary end points were progression-free survival (PFS) overall (OS). Objective response rate, duration response, secondary points. RESULTS In total, 299 305 randomly...
Background This phase Ib study evaluated the safety, clinical activity, pharmacokinetics, and pharmacodynamics (PD) of emactuzumab (anti-colony stimulating factor 1 receptor monoclonal antibody (mAb)) in combination with selicrelumab (agonistic cluster differentiation 40 mAb) patients advanced solid tumors. Methods Both were administered intravenously every 3 weeks doses concomitantly escalated (emactuzumab: 500 to 1000 mg flat; selicrelumab: 2 16 flat). Dose escalation was conducted using...
NKR-2 are autologous T cells genetically modified to express a chimeric antigen receptor (CAR) comprising fusion of the natural killer group 2D (NKG2D) with CD3ζ signalling domain, which associates adaptor molecule DNAX-activating protein 10 kDa (DAP10) provide co-stimulatory signal upon ligand binding. NKG2D binds eight different ligands expressed on cell surface many tumour and normally absent non-neoplastic cells. In preclinical studies, demonstrated long-term antitumour activity towards...
Background: Chemotherapy plays an important role in the treatment of early breast cancer (EBC). Granulocyte-colony stimulating factors (G-CSF) can reduce risk febrile neutropenia as primary prophylaxis (PP) or secondary (SP). The BRONS study investigated incidence serious neutropenic events (SNE) and G-CSF use a Belgian population EBC patients treated with myelosuppressive polychemotherapy.Methods: Conducted 2011, this was prospective, multicentre, observational trial involving 260 patients....
Dynamic response of arterial blood pressure during exercise has been studied in 40 normotensive young subjects and 20 mild hypertensive patients (20-40 years age). Hypertensive were treated with atenolol (beta blocker) prazosin (vasodilator). Both groups underwent maximal stress test. A double-blind nonrandomized study was practiced placebo, (3 mg/12 h), (100 mg/24 h). Heart rate (HR), systolic (SBP), diastolic (DBP), duration (ED) analyzed. All parameters remained stable both groups. The...