A5100450425- Pancreatic and Hepatic Oncology Research
- Lymphoma Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Gastric Cancer Management and Outcomes
- Acute Myeloid Leukemia Research
- Gallbladder and Bile Duct Disorders
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Chronic Myeloid Leukemia Treatments
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- Hematopoietic Stem Cell Transplantation
- Colorectal Cancer Surgical Treatments
- Viral-associated cancers and disorders
- Gastrointestinal Tumor Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroblastoma Research and Treatments
- Lung Cancer Treatments and Mutations
- Biosimilars and Bioanalytical Methods
- Peptidase Inhibition and Analysis
- Metastasis and carcinoma case studies
- COVID-19 Clinical Research Studies
- Intracranial Aneurysms: Treatment and Complications
- CAR-T cell therapy research
Yonsei University
2016-2025
Severance Hospital
2016-2025
Dong-A University
2004-2023
Celltrion (South Korea)
2019-2022
Inje University Busan Paik Hospital
2015-2022
Seoul National University Hospital
2007-2021
Armed Forces Capital Hospital
2019-2021
Hai phong University Of Medicine and Pharmacy
2021
Chonnam National University
2011-2020
Wonju Severance Christian Hospital
2020
The objective of this study was to clarify whether the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte (PLR) are significant prognostic markers in patients with resectable colorectal cancer (CRC). A total 200 who underwent curative resection for CRC were enrolled. NLR PLR positively correlated (p < 0.001). Both shown be good biomarkers overall survival (OS) = 0.002 p 0.001, respectively). an independent factor OS based on multivariate analysis (hazard ratio, 1.971; 95% confidence...
Abstract Background Several inflammatory response materials could be used for prediction of prognosis cancer patients. The neutrophil lymphocyte ratio (NLR), and the platelet (PLR) have been introduced prognostic scoring system in various cancers. objective this study was to determine whether NLR or PLR would predict clinical outcomes advanced gastric patients treated with oxaliplatin/ 5-fluorouracil (FOLFOX). Methods population consisted 174 Patients were 85 mg/m 2 oxaliplatin as a 2-h...
Abstract Background Regdanvimab (CT-P59) is a monoclonal antibody with neutralizing activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report on part 1 of 2-part randomized, placebo-controlled, double-blind study for patients mild-to-moderate disease 2019 (COVID-19). Methods Outpatients COVID-19 received single dose regdanvimab 40 mg/kg (n = 100), 80 103), or placebo 104). The primary end points were time to negative conversion SARS-CoV-2 from nasopharyngeal...
Neutropenia may limit the use of valganciclovir treatment for cytomegalovirus (CMV) infection following hematopoietic cell transplant (HCT). A phase 2 study indicated efficacy maribavir with fewer treatment-limiting toxicities than valganciclovir.
Neutralizing antibodies can reduce SARS-CoV-2 cellular entry, viral titers, and pathologic damage. CT-P59 (regdanvimab), a neutralizing monoclonal antibody, was examined in 2 randomized, double-blind, placebo-controlled, single ascending dose, Phase I studies.In study 1.1, healthy adults were sequentially enrolled to receive 10, 20, 40, or 80 mg/kg placebo. In 1.2, adult patients with mild infection Primary objectives of both studies safety tolerability up day 14 after infusion. Secondary...
Abstract Background Commercial anti-CD19 chimeric antigen receptor T-cell therapies (CART19) are efficacious against advanced B-cell non-Hodgkin lymphoma (NHL); however, most patients ultimately relapse. Several mechanisms contribute to this failure, including CD19-negative escape and CAR T dysfunction. All four commercial CART19 products utilize the FMC63 single-chain variable fragment (scFv) specific a CD19 membrane-distal epitope characterized by slow association (on) dissociation (off)...
Many factors influence bone metastases of lung cancer, and several studies report about survival skeletal metastasis. However, few have focused on identifying the prognostic for metastasis especially following orthopedic surgery. We conducted a retrospective analysis clinical characteristics from cancer discuss factors. performed medical record review 202 patients who were diagnosed with cancer. Adenocarcinoma was found in 116 (57.4%), squamous cell carcinoma 29 (14.4%), small-cell (SCLC) 37...
Background Decitabine was evaluated for its efficacy and safety in Korean patients with myelodysplastic syndrome IPSS score of 0.5 or over.Design Methods 20 mg/m2/day given intravenously over one hour five consecutive days every four weeks. The primary end point overall response rate.Results A total 101 were analyzed. International Prognostic Scoring System risk category Intermediate-2/High 47.5%. median 5 courses (range 1–18) delivered. rate 55.4% (13 complete responses, partial response,...
We evaluated clinical effectiveness of regdanvimab (CT-P59), a severe acute respiratory syndrome coronavirus 2 neutralizing monoclonal antibody, in reducing disease progression and recovery time patients with mild-to-moderate 2019 (COVID-19), primarily Alpha variant.This was phase 3 2/3 parallel-group, double-blind, randomized trial. Outpatients COVID-19 were to single-dose 40 mg/kg (n = 656) or placebo 659), alongside standard care. The primary endpoint up day 28 among "high-risk" patients....
The Systemic Inflammation Response Index (SIRI) has been used to predict the prognosis of various cancers. This study examined SIRI as a prognostic factor in neoadjuvant setting and determined whether it changing after chemotherapy is related patient prognosis.Patients who underwent pancreatic surgery following for cancer were retrospectively analyzed. To establish cut-off values, SIRIpre-neoadjuvant, SIRIpost-neoadjuvant, SIRIquotient (SIRIpost-neoadjuvant/SIRIpre-neoadjuvant) calculated...
Jin Seok Janga, Reyol Choi*a, Waqar Qureshib, Min Chan Kimc, Su Kimd, Sook Jeungd, Sang Young Hana, Myung Hwan Noha, Jong Hoon Leea, Seung Wook Yang Hyun Baeka, Sung Kima & Phil Jo Choiea Department of Internal Medicine, Dong-A Medical Center, University College Busan, South Koreab Michael E. DeBakey Veterans Affairs Center and Baylor Houston, Texas, USAc General Surgeryd Pathologye Cardiac Surgery, Korea
High-dose chemotherapy followed by autologous stem cell transplantation (HDT/ASCT) offers a rescue option for T lymphoma patients with poor prognosis. However, the effectiveness of HDT/ASCT in various peripheral subtypes, optimal transplant timing, and prognostic factors that predict better outcomes, have not been identified. We retrospectively investigated clinical outcomes 64 Korean lymphoma, unspecified (PTCL-U) between March 1995 February 2007. The median age at was 44 years (range:...
Abstract We examined the feasibility of explainable computer-aided detection cardiomegaly in routine clinical practice using segmentation-based methods. Overall, 793 retrospectively acquired posterior–anterior (PA) chest X-ray images (CXRs) patients were used to train deep learning (DL) models for lung and heart segmentation. The training dataset included PA CXRs from two public datasets in-house CXRs. Two fully automated methods state-of-the-art DL segmentation developed. diagnostic...
Abstract Background: Understanding the spatiotemporal dynamics of tumor microenvironment (TME) during treatment is crucial for improving outcomes in pancreatic ductal adenocarcinoma (PDAC). This study presents a pre-planned analysis from phase II trial evaluating neoadjuvant mFOLFIRINOX resectable PDAC, aimed at elucidating resistance mechanisms and identifying predictive biomarkers. Methods: multi-institutional, single-arm enrolled treatment-naïve patients with histologically confirmed PDAC...
OBJECTIVE HydroCoil (MicroVention, Aliso Viejo, CA), a hydrogel-platinum coil hybrid device, is one of various efforts to overcome delayed recanalization coiled intracranial aneurysms. The purpose this study was investigate the outcome aneurysms treated with HydroCoils. METHODS This multicenter prospective included 80 in 76 patients There were 32 (40%) ruptured and 48 (60%) unruptured aneurysms; 22 (28%) large (maximal diameter, ≥10 mm) 58 (72%) small. Aneurysm volumes 100 mm3 or more less...
The objective of this study was to determine whether the expressions excision cross-complementing (ERCC1), thymidylate synthase (TS) and glutathione S-transferase P1 (GSTP1) are predictive clinical outcomes in advanced gastric cancer (AGC) patients receiving treatment with adjuvant 5-fluorouracil (5-FU) cisplatin (FP) chemotherapy. One hundred forty nine were included study. ERCC1 GSTP1 expression correlated significantly tumor size (p = 0.040, p 0.018, respectively). Stage positive lymph...